Modulation of Cancer-Associated Fibrotic Stroma by An Integrin αvβ3 Targeting Protein for Pancreatic Cancer Treatment

Autor: Zhi-Ren Liu, Jenny J. Yang, Malvika Sharma, Shiyuan Wang, Falguni Mishra, Sun Li, Ravi Chakra Turaga, Alyssa M. Krasinskas, Yi Yuan, Chunfeng Liu

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 161-179 (2021)

Background & Aims Pancreatic ductal adenocarcinoma (PDAC) is resistant to most therapeutics owing to dense fibrotic stroma orchestrated by cancer-associated pancreatic stellate cells (CAPaSC). CAPaSC also support cancer cell growth, metastasis, and r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8771aab570fac7daa58c9d33c3452dcd
http://europepmc.org/articles/PMC7674520

3D heterospecies spheroids of pancreatic stroma and cancer cells demonstrate key phenotypes of pancreatic ductal adenocarcinoma

Autor: Xinyuan Liu, Rainer Heuchel, Jianping Liu, Anthony P. H. Wright, Gustav Arvidsson, Matthias Löhr, Beate Gündel, Xidan Li

Publikováno v: Translational Oncology
Translational Oncology, Vol 14, Iss 7, Pp 101107-(2021)

Highlights • We described a straightforward and highly reproducible 3D culturing method to investigate the intercellular crosstalk between pancreatic cancer and pancreatic stellate cells (PSCs)/cancer associated fibroblasts (CAFs). • Pancreatic d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309016806d03c6c70de0bb89b2ca621a
https://pubmed.ncbi.nlm.nih.gov/33946033

Identification of a novel PAK1 inhibitor to treat pancreatic cancer

Autor: Lingxia Zhu, Peng Cao, Yonghua Zhu, Jiao Chen, Rafael Rosell, Yuhan Yang, Chunping Hu, Xiaoyan Sun, Xueting Cai, Jiayu Zhao, Yang Yang, Jiaqi Wang

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 4, Pp 603-614 (2020)

Pancreatic cancer is one of the most aggressive cancers with poor prognosis and a low 5-year survival rate. The family of P21-activated kinases (PAKs) appears to modulate many signaling pathways that contribute to pancreatic carcinogenesis. In this w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0913dd0c804696dd82046e2f7cdf6b50
https://pubmed.ncbi.nlm.nih.gov/32322465

Pancreatic cancer spheres are more than just aggregates of stem marker-positive cells

Autor: Cinzia Giordano, Annette Bakker, Marco Rossi, Rossana Ritelli, Mario D'Andrea, Licia Montagna, Letizia Magnoni, Patrizia Tunici, Silvia Valensin, Margherita Gaviraghi, Aldo Scarpa

Publikováno v: Bioscience Reports

Pancreatic cancer stem-like cells are described by membrane expression of CD24, CD44 and ESA (epithelial-specific antigen) and their capacity to grow as spheres in a serum-free medium containing well-defined growth factors. The capacity of a panel of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4181059a6e46ecbce5c52562d00f1fef
https://doi.org/10.1042/bsr20100018

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