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Determination of the clinical relevance of donor epitope-specific HLA-antibodies in kidney transplantation.

Autor: Kardol-Hoefnagel T; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Senejohnny DM; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Kamburova EG; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Wisse BW; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Reteig L; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Gruijters ML; Renal Transplant Unit, Department of Internal Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands., Joosten I; Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Center, Nijmegen, The Netherlands., Allebes WA; Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Center, Nijmegen, The Netherlands., van der Meer A; Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Center, Nijmegen, The Netherlands., Hilbrands LB; Department of Nephrology, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., Baas MC; Department of Nephrology, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., Spierings E; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.; Central Diagnostic Laboratory (CDL), University Medical Center Utrecht, Utrecht, The Netherlands., Hack CE; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., van Reekum FE; Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands., van Zuilen AD; Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands., Verhaar MC; Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands., Bots ML; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Drop ACAD; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Plaisier L; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Melchers RCA; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Seelen MAJ; Department of Nephrology, University Medical Center Groningen, Groningen, The Netherlands., Sanders JS; Department of Nephrology, University Medical Center Groningen, Groningen, The Netherlands., Hepkema BG; Department of Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands., Lambeck AJA; Department of Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands., Bungener LB; Department of Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands., Roozendaal C; Department of Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands., Tilanus MGJ; Department of Transplantation Immunology, Tissue Typing Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands., Voorter CE; Department of Transplantation Immunology, Tissue Typing Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands., Wieten L; Department of Transplantation Immunology, Tissue Typing Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands., van Duijnhoven EM; Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center, Maastricht, The Netherlands., Gelens MACJ; Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center, Maastricht, The Netherlands., Christiaans MHL; Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center, Maastricht, The Netherlands., van Ittersum FJ; Department of Nephrology, Amsterdam University Medical Center, Amsterdam, The Netherlands., Nurmohamed SA; Department of Nephrology, Amsterdam University Medical Center, Amsterdam, The Netherlands., Lardy NM; Department of Immunogenetics, Sanquin Diagnostic Services, Amsterdam, The Netherlands., Swelsen W; Department of Immunogenetics, Sanquin Diagnostic Services, Amsterdam, The Netherlands., van der Pant KAMI; Renal Transplant Unit, Department of Internal Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands., van der Weerd NC; Renal Transplant Unit, Department of Internal Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands., Ten Berge IJM; Renal Transplant Unit, Department of Internal Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands., Hoitsma A; Dutch Organ Transplant Registry (NOTR), Dutch Transplant Foundation (NTS), Leiden, The Netherlands., van der Boog PJM; Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands., de Fijter JW; Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands., Betjes MGH; Department of Nephrology, Erasmus Medical Center, Rotterdam, The Netherlands., Roelen DL; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands., Claas FH; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands., Bemelman FJ; Renal Transplant Unit, Department of Internal Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands., Senev A; KU Leuven, Department of Microbiology, Immunology and Transplantation, KU Leuven University, Leuven, Belgium.; Histocompatibility and Immunogenetics Laboratory (HILA), Belgian Red Cross-Flanders, Mechelen, Belgium., Naesens M; KU Leuven, Department of Microbiology, Immunology and Transplantation, KU Leuven University, Leuven, Belgium.; Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium., Heidt S; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands., Otten HG; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.; Central Diagnostic Laboratory (CDL), University Medical Center Utrecht, Utrecht, The Netherlands.

Publikováno v: HLA [HLA] 2024 Jan; Vol. 103 (1), pp. e15346.

T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation.

Autor: Peereboom ETM; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Matern BM; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Tomosugi T; Department of Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan.; Department of Kidney Diseases and Transplant Immunology, Aichi Medical University School of Medicine, Nagakute, Japan., Niemann M; PIRCHE AG, Berlin, Germany., Drylewicz J; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Joosten I; Laboratory Medicine, Laboratory Medical Immunology, Radboud University Medical Center, Nijmegen, Netherlands., Allebes WA; Laboratory Medicine, Laboratory Medical Immunology, Radboud University Medical Center, Nijmegen, Netherlands., van der Meer A; Laboratory Medicine, Laboratory Medical Immunology, Radboud University Medical Center, Nijmegen, Netherlands., Hilbrands LB; Department of Nephrology, Radboud University Medical Center, Nijmegen, Netherlands., Baas MC; Department of Nephrology, Radboud University Medical Center, Nijmegen, Netherlands., van Reekum FE; Department of Nephrology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Verhaar MC; Department of Nephrology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Kamburova EG; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Seelen MAJ; Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Sanders JS; Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Hepkema BG; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Lambeck AJ; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Bungener LB; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Roozendaal C; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Tilanus MGJ; Department of Transplantation Immunology, Tissue Typing Laboratory, Maastricht University Medical Center, Maastricht, Netherlands., Voorter CE; Department of Transplantation Immunology, Tissue Typing Laboratory, Maastricht University Medical Center, Maastricht, Netherlands., Wieten L; Department of Transplantation Immunology, Tissue Typing Laboratory, Maastricht University Medical Center, Maastricht, Netherlands., van Duijnhoven EM; Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center, Maastricht, Netherlands., Gelens MACJ; Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center, Maastricht, Netherlands., Christiaans MHL; Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center, Maastricht, Netherlands., van Ittersum FJ; Department of Nephrology, Amsterdam University Medical Center, Amsterdam, Netherlands., Nurmohamed A; Department of Nephrology, Amsterdam University Medical Center, Amsterdam, Netherlands., Lardy NM; Department of Immunogenetics/HLA Diagnostic, Sanquin Diagnostic Services, Amsterdam, Netherlands., Swelsen W; Department of Immunogenetics/HLA Diagnostic, Sanquin Diagnostic Services, Amsterdam, Netherlands., van der Pant KA; Renal Transplant Unit, Department of Internal Medicine, Amsterdam University Medical Center, Amsterdam, Netherlands., van der Weerd NC; Renal Transplant Unit, Department of Internal Medicine, Amsterdam University Medical Center, Amsterdam, Netherlands., Ten Berge IJM; Renal Transplant Unit, Department of Internal Medicine, Amsterdam University Medical Center, Amsterdam, Netherlands., Bemelman FJ; Renal Transplant Unit, Department of Internal Medicine, Amsterdam University Medical Center, Amsterdam, Netherlands., de Vries APJ; Department of Nephrology, Leiden University Medical Center, Leiden, Netherlands., de Fijter JW; Department of Nephrology, Leiden University Medical Center, Leiden, Netherlands., Betjes MGH; Department of Internal Medicine, Erasmus MC, Rotterdam, Netherlands.; Department of Nephrology, Erasmus MC, Rotterdam, Netherlands., Roelen DL; Department of Immunology, Leiden University Medical Center, Leiden, Netherlands., Claas FH; Department of Immunology, Leiden University Medical Center, Leiden, Netherlands., Otten HG; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Heidt S; Department of Immunology, Leiden University Medical Center, Leiden, Netherlands., van Zuilen AD; Department of Nephrology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Kobayashi T; Department of Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Japan., Geneugelijk K; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Spierings E; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.

Publikováno v: Frontiers in immunology [Front Immunol] 2021 Nov 18; Vol. 12, pp. 784040. Date of Electronic Publication: 2021 Nov 18 (Print Publication: 2021).

Allocation to highly sensitized patients based on acceptable mismatches results in low rejection rates comparable to nonsensitized patients.

Autor: Heidt S; Eurotransplant Reference Laboratory, Leiden University Medical Center, Leiden, the Netherlands., Haasnoot GW; Eurotransplant Reference Laboratory, Leiden University Medical Center, Leiden, the Netherlands., Witvliet MD; Eurotransplant Reference Laboratory, Leiden University Medical Center, Leiden, the Netherlands., van der Linden-van Oevelen MJH; Eurotransplant Reference Laboratory, Leiden University Medical Center, Leiden, the Netherlands., Kamburova EG; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Wisse BW; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Joosten I; Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Laboratory Medicine, Laboratory of Medical Immunology, Nijmegen, the Netherlands., Allebes WA; Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Laboratory Medicine, Laboratory of Medical Immunology, Nijmegen, the Netherlands., van der Meer A; Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Laboratory Medicine, Laboratory of Medical Immunology, Nijmegen, the Netherlands., Hilbrands LB; Radboud University Medical Center, Department of Nephrology, Radboud Institute for Health Sciences, Nijmegen, the Netherlands., Baas MC; Radboud University Medical Center, Department of Nephrology, Radboud Institute for Health Sciences, Nijmegen, the Netherlands., Spierings E; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Hack CE; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., van Reekum FE; Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., van Zuilen AD; Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Verhaar MC; Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Bots ML; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Drop ACAD; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Plaisier L; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Seelen MAJ; Department of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Sanders JS; Department of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Hepkema BG; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Lambeck AJA; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Bungener LB; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Roozendaal C; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Tilanus MGJ; Department of Transplantation Immunology, Tissue Typing Laboratory, Maastricht University Medical Centre, Maastricht, the Netherlands., Voorter CE; Department of Transplantation Immunology, Tissue Typing Laboratory, Maastricht University Medical Centre, Maastricht, the Netherlands., Wieten L; Department of Transplantation Immunology, Tissue Typing Laboratory, Maastricht University Medical Centre, Maastricht, the Netherlands., van Duijnhoven EM; Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Centre, Maastricht, the Netherlands., Gelens MACJ; Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Centre, Maastricht, the Netherlands., Christiaans MHL; Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Centre, Maastricht, the Netherlands., van Ittersum FJ; Department of Nephrology, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Nurmohamed SA; Department of Nephrology, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Lardy NM; Department of Immunogenetics, Sanquin Diagnostic Services, Amsterdam, the Netherlands., Swelsen W; Department of Immunogenetics, Sanquin Diagnostic Services, Amsterdam, the Netherlands., van der Pant KAMI; Department of Internal Medicine, Amsterdam University Medical Center, University of Amsterdam, Renal Transplant Unit, Amsterdam, the Netherlands., van der Weerd NC; Department of Internal Medicine, Amsterdam University Medical Center, University of Amsterdam, Renal Transplant Unit, Amsterdam, the Netherlands., Ten Berge IJM; Department of Internal Medicine, Amsterdam University Medical Center, University of Amsterdam, Renal Transplant Unit, Amsterdam, the Netherlands., Bemelman FJ; Department of Internal Medicine, Amsterdam University Medical Center, University of Amsterdam, Renal Transplant Unit, Amsterdam, the Netherlands., Hoitsma A; Dutch Organ Transplant Registry (NOTR), Dutch Transplant Foundation (NTS), Leiden, the Netherlands., van der Boog PJM; Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands., de Fijter JW; Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands., Betjes MGH; Department of Nephrology, Erasmus Medical Center, Rotterdam, the Netherlands., Otten HG; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Roelen DL; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands., Claas FHJ; Eurotransplant Reference Laboratory, Leiden University Medical Center, Leiden, the Netherlands.

Publikováno v: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2019 Oct; Vol. 19 (10), pp. 2926-2933. Date of Electronic Publication: 2019 Jul 01.

Effect of initial immunosuppression on long-term kidney transplant outcome in immunological low-risk patients.

Autor: Michielsen LA; Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., van Zuilen AD; Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Verhaar MC; Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Wisse BW; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Kamburova EG; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Joosten I; Laboratory Medicine, Lab. Medical Immunology, Radboud University Medical Center, Nijmegen, The Netherlands., Allebes WA; Laboratory Medicine, Lab. Medical Immunology, Radboud University Medical Center, Nijmegen, The Netherlands., van der Meer A; Laboratory Medicine, Lab. Medical Immunology, Radboud University Medical Center, Nijmegen, The Netherlands., Baas MC; Radboud Institute for Health Sciences, Department of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands., Spierings E; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Hack CE; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., van Reekum FE; Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Bots ML; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Drop ACAD; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Plaisier L; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Seelen MAJ; Department of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Sanders JF; Department of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Hepkema BG; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Lambeck AJ; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Bungener LB; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Roozendaal C; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Tilanus MGJ; Department of Transplantation Immunology, Tissue Typing Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands., Voorter CE; Department of Transplantation Immunology, Tissue Typing Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands., Wieten L; Department of Transplantation Immunology, Tissue Typing Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands., van Duijnhoven EM; Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center, Maastricht, The Netherlands., Gelens MACJ; Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center, Maastricht, The Netherlands., Christiaans MHL; Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center, Maastricht, The Netherlands., van Ittersum FJ; Department of Nephrology, Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands., Nurmohamed SA; Department of Nephrology, Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands., Lardy NM; Department of Immunogenetics, Sanquin, Amsterdam, The Netherlands., Swelsen W; Department of Immunogenetics, Sanquin, Amsterdam, The Netherlands., van der Pant KA; Renal Transplant Unit, Department of Internal Medicine, Amsterdam UMC, Academic Medical Center, Amsterdam, The Netherlands., van der Weerd NC; Renal Transplant Unit, Department of Internal Medicine, Amsterdam UMC, Academic Medical Center, Amsterdam, The Netherlands., Ten Berge IJM; Renal Transplant Unit, Department of Internal Medicine, Amsterdam UMC, Academic Medical Center, Amsterdam, The Netherlands., Bemelman FJ; Renal Transplant Unit, Department of Internal Medicine, Amsterdam UMC, Academic Medical Center, Amsterdam, The Netherlands., Hoitsma A; Dutch Organ Transplant Registry (NOTR), Dutch Transplant Foundation (NTS), Leiden, The Netherlands., van der Boog PJM; Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands., de Fijter JW; Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands., Betjes MGH; Department of Nephrology, Erasmus Medical Center, Rotterdam, The Netherlands., Heidt S; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands., Roelen DL; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands., Claas FH; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands., Otten HG; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Hilbrands LB; Radboud Institute for Health Sciences, Department of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands.

Publikováno v: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association [Nephrol Dial Transplant] 2019 Aug 01; Vol. 34 (8), pp. 1417-1422.