Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V

Autor: Anniek F. Lubberding, Jinyi Zhang, Morten Lundh, Thomas Svava Nielsen, Mathilde S. Søndergaard, Maria Villadsen, Emil Z. Skovhøj, Geke A. Boer, Jakob B. Hansen, Morten B. Thomsen, Jonas T. Treebak, Jens J. Holst, Jørgen K. Kanters, Thomas Mandrup-Poulsen, Thomas Jespersen, Brice Emanuelli, Signe S. Torekov

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Abstract Loss-of-function (LoF) mutations in KCNQ1, encoding the voltage-gated K+ channel Kv7.1, lead to long QT syndrome 1 (LQT1). LQT1 patients also present with post-prandial hyperinsulinemia and hypoglycaemia. In contrast, KCNQ1 polymorphisms are

Externí odkaz: https://doaj.org/article/bdb0c435470a478696e2cc00273a4925

Glucose‐dependent insulinotropic polypeptide receptor antagonist treatment causes a reduction in weight gain in ovariectomised high fat diet‐fed mice

Autor: Geke Aline Boer, Jenna Elizabeth Hunt, Maria Buur Nordskov Gabe, Johanne Agerlin Windeløv, Alexander Hovard Sparre‐Ulrich, Bolette Hartmann, Jens Juul Holst, Mette Marie Rosenkilde

Publikováno v: Boer, G A, Hunt, J E, Gabe, M B N, Windeløv, J A, Sparre-Ulrich, A H, Hartmann, B, Holst, J J & Rosenkilde, M M 2022, ' Glucose-dependent insulinotropic polypeptide receptor antagonist treatment causes a reduction in weight gain in ovariectomised high fat diet-fed mice ', British Journal of Pharmacology, vol. 179, no. 18, pp. 4486-4499 . https://doi.org/10.1111/bph.15894

BACKGROUND AND PURPOSE: The incretin hormone, gastric inhibitory peptide/glucose-dependent insulinotropic polypeptide (GIP), secreted by the enteroendocrine K-cells in the proximal intestine, may regulate lipid metabolism and adiposity, but its exact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482b7e6e6dce29f368aeca4fe84df548
https://doi.org/10.1111/bph.15894

GIP receptor antagonist treatment causes weight loss in ovariectomized high fat diet-fed mice

Autor: Alexander Sparre-Ulricht, Jens J. Holst, Bolette Hartmann, Mette M. Rosenkilde, Jenna Hunt, Johanne Agerlin Windeløv, Maria Buur Nordskov Gabe, Geke Aline Boer

Background and purpose The incretin hormone, glucose-dependent insulinotropic polypeptide (GIP), secreted by the enteroendocrine K-cells in the proximal intestine, may regulate lipid metabolism and adiposity but its exact role in these processes is u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b58e1722cd35421f7c069aae1ab935d
https://doi.org/10.22541/au.162303461.16209224/v1

Development of high-affinity agonist- and antagonist radioligands for the GLP-2 receptor - powerful tools for the study of GLP-2 pharmacology

Autor: Wijnand J.C. van der Velden, Jens J. Holst, Mette M. Rosenkilde, Geke Aline Boer, Hannelouise Kissow, Sarina Gadgaard, Cathrine Ørskov, Maria Buur Nordskov Gabe, Jenna Hunt, Johanne Agerlin Windeløv, Bolette Hartmann, Sine P. Schiellerup

Background: Glucagon-like peptide-2 (GLP-2) is a 33 amino acid pro-glucagon-derived hormone produced in the intestinal enteroendocrine L-cells with trophic actions on both the gut and bones. GLP-2(1-33) is cleaved by the ubiquitous protease dipeptidy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99fd59f3db37de412b31eba7caa04f70
https://doi.org/10.22541/au.159818456.67954631

Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V

Autor: Jinyi Zhang, Brice Emanuelli, Signe S. Torekov, Geke Aline Boer, Jakob Bondo Hansen, Maria Villadsen, Thomas Nielsen, Jørgen K. Kanters, Thomas Jespersen, Anniek F. Lubberding, Jens J. Holst, Mathilde S Søndergaard, Jonas T. Treebak, Morten B. Thomsen, Thomas Mandrup-Poulsen, Emil Z Skovhøj, Morten Lundh

Publikováno v: Scientific Reports
Lubberding, A F, Zhang, J, Lundh, M, Nielsen, T S, Søndergaard, M S, Villadsen, M, Skovhøj, E Z, Boer, G A, Hansen, J B, Thomsen, M B, Treebak, J T, Holst, J J, Kanters, J K, Mandrup-Poulsen, T, Jespersen, T, Emanuelli, B & Torekov, S S 2021, ' Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V ', Scientific Reports, vol. 11, no. 1, 12253 . https://doi.org/10.1038/s41598-021-90452-8
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Loss-of-function (LoF) mutations in KCNQ1, encoding the voltage-gated K+ channel Kv7.1, lead to long QT syndrome 1 (LQT1). LQT1 patients also present with post-prandial hyperinsulinemia and hypoglycaemia. In contrast, KCNQ1 polymorphisms are associat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9902ca1f08671d1ab0a31c6c493dbc02
https://pubmed.ncbi.nlm.nih.gov/34112814