Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Gek Ming Sia"'
Publikováno v:
Glia
Glia, vol 70, iss 3
Glia, vol 70, iss 3
The classical complement cascade mediates synapse elimination in the visual thalamus during early brain development. However, whether the primary visual cortex also undergoes complement-mediated synapse elimination during early visual system developm
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199399 (2018)
The FoxP2 transcription factor and its target genes have been implicated in developmental brain diseases with a prominent language component, such as developmental verbal dyspraxia and specific language impairment. How FoxP2 affects neural circuitry
Externí odkaz:
https://doaj.org/article/7c0ff7a8d1ba4cc8b8d1174560a4a56a
Publikováno v:
Trends Neurosci
Complement-mediated synapse elimination has emerged as an important process in both brain development and neurological diseases, but whether neurons express complement inhibitors that protect synapses against complement-mediated synapse elimination r
Autor:
Gek Ming Sia, Breeanne M. Soteros
Publikováno v:
WIREs Mech Dis
Synapse elimination, also known as synaptic pruning, is a critical step in the maturation of neural circuits during brain development. Mounting evidence indicates that the complement cascade of the innate immune system plays an important role in syna
Publikováno v:
Science. 342:987-991
Building Vocalization The transcription factor FoxP2 (forkhead box P2) affects language acquisition in humans and regulates the protein SRPX2 (sushi repeat-containing protein X-linked 2), which itself also affects language. Sia et al. (p. 987 , publi
Publikováno v:
Molecular Immunology. 102:140
Autor:
Noah W. Gray, Zaza Khuchua, Richard L. Huganir, Karel Svoboda, Haining Zhong, Gek Ming Sia, Tianyi Mao, Takashi R. Sato
Publikováno v:
Neuron. 62:363-374
Protein kinase A (PKA) plays multiple roles in neurons. The localization and specificity of PKA are largely controlled by A-kinase anchoring proteins (AKAPs). However, the dynamics of PKA in neurons, and the roles of specific AKAPs, are poorly unders
Autor:
Abhay Moghekar, Xiaopei Tang, Gek Ming Sia, Richard O'Brien, John L. Black, Kenneth M. Rosen, Richard L. Huganir, Maureen W. McEnery, Ruifa Mi
Publikováno v:
Neuron. 44:335-349
Under standard conditions, cultured ventral spinal neurons cluster AMPA- but not NMDA-type glutamate receptors at excitatory synapses on their dendritic shafts in spite of abundant expression of the ubiquitous NMDA receptor subunit NR1. We demonstrat
Autor:
Gavin Rumbaugh, Jean-Claude Béïque, Richard W. Cho, Paul F. Worley, Richard L. Huganir, Gek Ming Sia
Publikováno v:
Neuron. 55(3)
SummarySynaptogenesis requires recruitment of neurotransmitter receptors to developing postsynaptic specializations. We developed a coculture system reconstituting artificial synapses between neurons and nonneuronal cells to investigate the molecular
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(11)
Members of the synapse-associated protein-97 (SAP97) family of scaffold proteins have been implicated as central organizers of synaptic junctions to build macromolecular signaling complexes around specific postsynaptic neurotransmitter receptors. In