Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Gejing Deng"'
Autor:
Michael Lampa, Heike Arlt, Timothy He, Beatriz Ospina, Jason Reeves, Bailin Zhang, Joshua Murtie, Gejing Deng, Claude Barberis, Dietmar Hoffmann, Hong Cheng, Jack Pollard, Christopher Winter, Victoria Richon, Carlos Garcia-Escheverria, Francisco Adrian, Dmitri Wiederschain, Lakshmi Srinivasan
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185092 (2017)
Tumor cells display fundamental changes in metabolism and nutrient uptake in order to utilize additional nutrient sources to meet their enhanced bioenergetic requirements. Glutamine (Gln) is one such nutrient that is rapidly taken up by tumor cells t
Externí odkaz:
https://doaj.org/article/47010cd775964d039d9705a804380307
Autor:
Beat Nyfeler, Dominic Hoepfner, Deborah Palestrant, Christina A Kirby, Lewis Whitehead, Robert Yu, Gejing Deng, Ruth E Caughlan, Angela L Woods, Adriana K Jones, S Whitney Barnes, John R Walker, Swann Gaulis, Ervan Hauy, Saskia M Brachmann, Philipp Krastel, Christian Studer, Ralph Riedl, David Estoppey, Thomas Aust, N Rao Movva, Zuncai Wang, Michael Salcius, Gregory A Michaud, Gregory McAllister, Leon O Murphy, John A Tallarico, Christopher J Wilson, Charles R Dean
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e42657 (2012)
Argyrins, produced by myxobacteria and actinomycetes, are cyclic octapeptides with antibacterial and antitumor activity. Here, we identify elongation factor G (EF-G) as the cellular target of argyrin B in bacteria, via resistant mutant selection and
Externí odkaz:
https://doaj.org/article/8cc21bffe9b742f29677cb5ec08eb108
Autor:
Btissam Chami, Makoto Okuda, Morvarid Moayeri, France Pirenne, Yoko Hidaka, Ashok Nambiar, Zhili Song, Olivier Bedel, Bailin Zhang, Joern Hopke, Gejing Deng, Chen Zhu, Sandrine Macé, Marielle Chiron, Francisco Adrian, Taro Fukao, Frank G. Basile, Thomas Martin
Publikováno v:
Transfusion. 62:2334-2348
There are two FDA-approved anti-CD38 monoclonal antibodies for treatment of multiple myeloma: isatuximab and daratumumab. Owing to expression of CD38 on reagent red blood cells (RBCs), these antibodies interfere with indirect antiglobulin tests (IATs
Autor:
Edward Seung, Zhen Xing, Lan Wu, Ercole Rao, Virna Cortez-Retamozo, Beatriz Ospina, Liqing Chen, Christian Beil, Zhili Song, Bailin Zhang, Mikhail Levit, Gejing Deng, Andrew Hebert, Patrick Kirby, Aiqun Li, Emma-Jane Poulton, Rita Vicente, Audrey Garrigou, Peter Piepenhagen, Greg Ulinski, Michele Sanicola-Nadel, Dinesh S. Bangari, Huawei Qiu, Lily Pao, Dmitri Wiederschain, Ronnie Wei, Zhi-yong Yang, Gary J. Nabel
Publikováno v:
Nature. 603:328-334
Effective antitumour immunity depends on the orchestration of potent T cell responses against malignancies
Autor:
Dana M. Lord, Katarina Radosevic, Christian Beil, Gregory Ulinski, Thomas Bertrand, Cendrine Lemoine, Zhi Yong Yang, Srinivas S. Rao, Ronnie Wei, Gejing Deng, Béatrice Cameron, Valeriya Posternak, Bailin Zhang, Paul Ferrari, Lan Wu, Zhili Song, Tarik Dabdoubi, Aiqun Li, Virna Cortez-Retamozo, Stéphanie Pouzieux, Marielle Chiron, Gary J. Nabel, Jennifer Fretland, Fangxian Sun, Anna Park, Nizar El-Murr, Rita Vicente, Elisa Francesconi, Ercole Rao, Peter A. Piepenhagen, Catherine Prades, Huawei Qiu, Edward Seung, Beatriz Ospina, Patrick Kirby, Ling Xu
Publikováno v:
Nature Cancer. 1:86-98
Despite the significant therapeutic advances provided by immune-checkpoint blockade and chimeric antigen receptor T cell treatments, many malignancies remain unresponsive to immunotherapy. Bispecific antibodies targeting tumor antigens and activating
Autor:
Edward Seung, Zhen Xing, Lan Wu, Ercole Rao, Virna Cortez-Retamozo, Beatriz Ospina, Liqing Chen, Christian Beil, Zhili Song, Bailin Zhang, Mikhail Levit, Gejing Deng, Andrew Hebert, Patrick Kirby, Aiqun Li, Emma-Jane Poulton, Rita Vicente, Audrey Garrigou, Peter Piepenhagen, Greg Ulinski, Michele Sanicola-Nadel, Dinesh S. Bangari, Huawei Qiu, Lily Pao, Dmitri Wiederschain, Ronnie Wei, Zhi-yong Yang, Gary J. Nabel
Publikováno v:
Nature. 604:E13-E13
Autor:
Timothy He, Hong Cheng, Bailin Zhang, Stephanie Vougier, Paul Ferrari, Olivier Bedel, Stuart Licht, Gejing Deng, Rosalia Arrebola, Jessica McManus, Timothy Gillespy, Julie-Ann Gavigan, Richard Gregory, Ghislaine Marchand
Publikováno v:
SLAS Discovery. 23:264-273
CD73/Ecto-5'-nucleotidase is a membrane-tethered ecto-enzyme that works in tandem with CD39 to convert extracellular adenosine triphosphate (ATP) into adenosine. CD73 is highly expressed on various types of cancer cells and on infiltrating suppressiv
Autor:
Zachary Mankoff, Ronnie Wei, Dennis R. Burton, Krisha McKee, Dana M. Lord, Richard A. Koup, Christian Lange, Wulf Dirk Leuschner, Keyun Wang, Mario Roederer, Stephen D. Schmidt, Tongqing Zhou, Dan H. Barouch, Rebecca Sendak, Lawrence J. Tartaglia, Sijy O'Dell, Zhi Yong Yang, Misook Choe, Robert T. Bailer, Lan Wu, John R. Mascola, Mangaiarkarasi Asokan, Young Do Kwon, Amarendra Pegu, Ercole Rao, Ling Xu, Mark Connors, Peter D. Kwong, Jochen Kruip, Xuejun Chen, John-Paul Todd, Gejing Deng, Mark K. Louder, Gary J. Nabel, Nicole A. Doria-Rose, Christian Beil, Jochen Beninga
Publikováno v:
Science. 358:85-90
A triple threat for HIV The HIV virus continually evolves tricks to evade elimination by the host. Prevention and a cure will likely rely on broadly neutralizing antibodies that can recognize and conquer multiple viral strains or subtypes. Xu et al.
Autor:
Zhili Song, Olivier Bedel, Bailin Zhang, Joern Hopke, Gejing Deng, Sandrine Macé, Marielle Chiron, Francisco Adrian, Taro Fukao, Frank Basile, France Pirenne, Makoto Okuda, Morvarid Moayeri, Btissam Chami, Yoko Hidaka, Ashok Nambiar, Thomas Martin, Chen Zhu
Publikováno v:
Cancer Research. 81:1888-1888
Introduction: Two anti-CD38 monoclonal antibodies (mAb) are approved for the treatment of multiple myeloma: isatuximab (Isa) and daratumumab (Dara); binding to CD38 on red blood cells (RBCs) results in false positive agglutination on indirect antiglo
Autor:
Yi Li, Gejing Deng, Vinod Patel, Dmitri Wiederschain, Ming Yin, Chaomei Shi, Olivier Bedel, Magali Mathieu, Stefan Gross, Aurelie Vassort, Qiang Gao, Frank Le-Strat, Alexey Rak, Bailin Zhang, Junqing Shen, Timothy He, Ying Zhang, Eamonn Rooney, Francisco Adrian, Patricia Gee, Walter Englaro, Hong Cheng, Dietmar Hoffmann, Jean-Pierre Marquette, Larry R. McLean, Jessica McManus, Stuart Licht
Publikováno v:
Journal of Biological Chemistry. 290:762-774
Cancer-associated point mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) confer a neomorphic enzymatic activity: the reduction of α-ketoglutarate to d-2-hydroxyglutaric acid, which is proposed to act as an oncogenic metabolite by induci