Synergistic Combination of Calcium and Citrate in Mesoporous Nanoparticles Targets Pleural Tumors

Autor: Schirnding, C. von, Giopanou, I., Hermawan, A., Wehl, L., Ntaliarda, G., Illes, B., Datz, S., Geisslinger, F., Bartel, K., Sommer, A.-K., Lianou, M., Weiß, V., Feckl, J., Vollmar, A.M., Bräuchle, C., Stathopoulos, G.T., Wagner, E., Roidl, A., Bein, T., Engelke, H.

Conventional chemotherapy leads to severe adverse effects since it involves systemic administration of toxic drugs at high dosage. Unlike traditional chemotherapeutics, calcium phosphate and citrate have both been discussed as very promising anticanc

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https://publica.fraunhofer.de/handle/publica/268452

Targeting TPC2 sensitizes acute lymphoblastic leukemia cells to chemotherapeutics by impairing lysosomal function.

Autor: Geisslinger F; Ludwig-Maximilians University, Departement of Pharmacy, Pharmaceutical Biology, Munich, Germany., Müller M; Ludwig-Maximilians University, Departement of Pharmacy, Pharmaceutical Biology, Munich, Germany., Chao YK; Ludwig-Maximilians University, Walther-Straub-Institute of Pharmacology and Toxicology, Munich, Germany., Grimm C; Ludwig-Maximilians University, Walther-Straub-Institute of Pharmacology and Toxicology, Munich, Germany., Vollmar AM; Ludwig-Maximilians University, Departement of Pharmacy, Pharmaceutical Biology, Munich, Germany., Bartel K; Ludwig-Maximilians University, Departement of Pharmacy, Pharmaceutical Biology, Munich, Germany. karin.bartel@cup.uni-muenchen.de.

Publikováno v: Cell death & disease [Cell Death Dis] 2022 Aug 01; Vol. 13 (8), pp. 668. Date of Electronic Publication: 2022 Aug 01.

Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth.

Autor: Müller M; Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University Munich, 81377 Munich, Germany., Gerndt S; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-University Munich, 81377 Munich, Germany., Chao YK; Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilians-University Munich, 80336 Munich, Germany., Zisis T; Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University Munich, 81377 Munich, Germany., Nguyen ONP; Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University Munich, 81377 Munich, Germany., Gerwien A; Department of Chemistry and Munich Center for Integrated Protein Science (CIPSM), Ludwig-Maximilians-University Munich, 81377 Munich, Germany., Urban N; Rudolf-Boehm-Institute of Pharmacology and Toxicology, Leipzig University, 04107 Leipzig, Germany., Müller C; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-University Munich, 81377 Munich, Germany., Gegenfurtner FA; Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University Munich, 81377 Munich, Germany., Geisslinger F; Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University Munich, 81377 Munich, Germany., Ortler C; Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University Munich, 81377 Munich, Germany., Chen CC; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, 100 Taipei, Taiwan., Zahler S; Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University Munich, 81377 Munich, Germany., Biel M; Department of Pharmacy, Pharmacology, Ludwig-Maximilians-University Munich, 81377 Munich, Germany., Schaefer M; Rudolf-Boehm-Institute of Pharmacology and Toxicology, Leipzig University, 04107 Leipzig, Germany., Grimm C; Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilians-University Munich, 80336 Munich, Germany. Electronic address: christian.grimm@med.uni-muenchen.de., Bracher F; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-University Munich, 81377 Munich, Germany. Electronic address: franz.bracher@cup.uni-muenchen.de., Vollmar AM; Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University Munich, 81377 Munich, Germany. Electronic address: angelika.vollmar@cup.uni-muenchen.de., Bartel K; Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University Munich, 81377 Munich, Germany. Electronic address: karin.bartel@cup.uni-muenchen.de.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2021 Aug 19; Vol. 28 (8), pp. 1119-1131.e27. Date of Electronic Publication: 2021 Feb 23.

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Targeting Lysosomes in Cancer as Promising Strategy to Overcome Chemoresistance-A Mini Review.

Autor: Geisslinger F; Pharmaceutical Biology, Department Pharmacy, Ludwig-Maximilians-University of Munich, Munich, Germany., Müller M; Pharmaceutical Biology, Department Pharmacy, Ludwig-Maximilians-University of Munich, Munich, Germany., Vollmar AM; Pharmaceutical Biology, Department Pharmacy, Ludwig-Maximilians-University of Munich, Munich, Germany., Bartel K; Pharmaceutical Biology, Department Pharmacy, Ludwig-Maximilians-University of Munich, Munich, Germany.

Publikováno v: Frontiers in oncology [Front Oncol] 2020 Jul 09; Vol. 10, pp. 1156. Date of Electronic Publication: 2020 Jul 09 (Print Publication: 2020).