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Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia.

Autor: Swingle KL; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Hamilton AG; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Safford HC; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Geisler HC; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Thatte AS; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Palanki R; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Murray AM; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Han EL; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Mukalel AJ; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Han X; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Joseph RA; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Ghalsasi AA; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Alameh MG; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn Institute for RNA Innovation, Perelman School of Medicine, Philadelphia, PA, USA., Weissman D; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn Institute for RNA Innovation, Perelman School of Medicine, Philadelphia, PA, USA., Mitchell MJ; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA. mjmitch@seas.upenn.edu.; Penn Institute for RNA Innovation, Perelman School of Medicine, Philadelphia, PA, USA. mjmitch@seas.upenn.edu.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. mjmitch@seas.upenn.edu.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. mjmitch@seas.upenn.edu.; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. mjmitch@seas.upenn.edu.; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. mjmitch@seas.upenn.edu.

Publikováno v: Nature [Nature] 2024 Dec 11. Date of Electronic Publication: 2024 Dec 11.