A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis

Autor: Spilker, Christina, Nullmeier, Sven, Grochowska, Katarzyna, Schumacher, Anne, Butnaru, Ioana, Macharadze, Tamar, Monteiro Gomes, Guilherme, Yuanxiang, PingAn, BAYRAKTAR, Gonca, Rodenstein, Carolin, Geiseler, Carolin, Kolodziej, Angela, Lopez-Rojas, Jeffrey, Montag, Dirk, Angenstein, Frank, Bär, Julia, D’Hanis, Wolfgang, Roskoden, Thomas, Mikhaylova, Marina, Budinger, Eike, Ohl, Frank W., Stork, Oliver, Zenclussen, Ana C., Karpova, Anna, Schwegler, Herbert, Kreutz, Michael R.

Publikováno v: PLoS Genetics, Vol 12, Iss 3, p e1005907 (2016)
PLoS Genetics
PLoS Genetics 12(3), e1005907 (2016). doi:10.1371/journal.pgen.1005907
PLoS Genetics, 12(3): e1005907

Jacob, the protein encoded by the Nsmf gene, is involved in synapto-nuclear signaling and docks an N-Methyl-D-Aspartate receptor (NMDAR)-derived signalosome to nuclear target sites like the transcription factor cAMP-response-element-binding protein (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bc2381f03bb11b045a09d85ee63448c2
http://europepmc.org/articles/PMC4792503?pdf=render