A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes.

Autor: Pao PC; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139., Seo J; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Brain Sciences, Daegu Gyeongbuk Institute for Science and Technology, Daegu 42988, South Korea., Lee A; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139., Kritskiy O; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139., Patnaik D; Chemical Neurobiology Laboratory, Center for Genomic Medicine, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114., Penney J; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139., Raju RM; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139.; Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115., Geigenmuller U; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139., Silva MC; Chemical Neurobiology Laboratory, Center for Genomic Medicine, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114., Lucente DE; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Massachusetts General Hospital Frontotemporal Disorders Unit, Gerontology Research Unit, and Alzheimer's Disease Research Center, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129., Gusella JF; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02114., Dickerson BC; Massachusetts General Hospital Frontotemporal Disorders Unit, Gerontology Research Unit, and Alzheimer's Disease Research Center, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129., Loon A; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139., Yu MX; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139., Bula M; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139., Yu M; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139., Haggarty SJ; Chemical Neurobiology Laboratory, Center for Genomic Medicine, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114., Tsai LH; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Apr 18; Vol. 120 (16), pp. e2217864120. Date of Electronic Publication: 2023 Apr 12.

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