An "off-the-shelf" fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies.

Autor: Cooper ML; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA. matthewcooper@wustl.edu., Choi J; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Staser K; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Department of Internal Medicine, Division of Dermatology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Ritchey JK; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Devenport JM; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Eckardt K; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Rettig MP; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Wang B; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Eissenberg LG; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Ghobadi A; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Gehrs LN; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Prior JL; Mallinckrodt Institute of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, 63110, USA., Achilefu S; Mallinckrodt Institute of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, 63110, USA., Miller CA; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA.; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, 63108, USA., Fronick CC; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, 63108, USA., O'Neal J; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Gao F; Department of Surgery, Division of Public Health Sciences, Washington University School of Medicine, St. Louis, MO, 63110, USA., Weinstock DM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Gutierrez A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, 02215, USA., Fulton RS; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, 63108, USA., DiPersio JF; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA. jdipersi@wustl.edu.

Publikováno v: Leukemia [Leukemia] 2018 Sep; Vol. 32 (9), pp. 1970-1983. Date of Electronic Publication: 2018 Feb 20.