Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Gehao Liang"'
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive tumor with extremely poor prognosis due to the low resection rate, high recurrence rate and drug resistance. Uridine-cytidine kinase 2 (UCK2) is proved to promote progression and
Externí odkaz:
https://doaj.org/article/efcb984f4d034aa7a9bf4bf90fd3bbf8
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Cuproptosis-related lncRNAs regulate the biological functions of various cancers. However, the role of cuproptosis-related lncRNAs in breast cancer remains unclear. In this study, we investigated the biological functions and clinical appl
Externí odkaz:
https://doaj.org/article/dfe0c0f36f1e41d196fcd5734b2acc7d
Autor:
Yun Ling, Gehao Liang, Qun Lin, Xiaolin Fang, Qing Luo, Yinghuan Cen, Maryam Mehrpour, Ahmed Hamai, Zihao Liu, Yu Shi, Juanmei Li, Wanyi Lin, Shijie Jia, Wenqian Yang, Qiang Liu, Erwei Song, Jun Li, Chang Gong
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-16 (2022)
Abstract Background Approximate 25% HER2-positive (HER2+) breast cancer (BC) patients treated with trastuzumab recurred rapidly. However, the mechanisms underlying trastuzumab resistance remained largely unclear. Methods Trastuzumab-resistant associa
Externí odkaz:
https://doaj.org/article/4cb4e58d00b444528e8ee7b096a49c0f
Autor:
Huizhen Ye, Youyuan Chen, Peiyi Ye, Yu Zhang, Xiaoyi Liu, Guanqing Xiao, Zhe Zhang, Yaozhong Kong, Gehao Liang
Publikováno v:
BMC Nephrology, Vol 22, Iss 1, Pp 1-9 (2021)
Abstract Background Chronic kidney disease (CKD) is a common health challenge. There are some risk models predicting CKD adverse outcomes, but seldom focus on the Mongoloid population in East Asian. So, we developed a simple but intuitive nomogram mo
Externí odkaz:
https://doaj.org/article/c84fc4b7b2c849f79757d0f8f85c974f
Autor:
Gehao Liang, Yun Ling, Maryam Mehrpour, Phei Er Saw, Zihao Liu, Weige Tan, Zhenluan Tian, Wenjing Zhong, Wanyi Lin, Qing Luo, Qun Lin, Qiufang Li, You Zhou, Ahmed Hamai, Patrice Codogno, Jun Li, Erwei Song, Chang Gong
Publikováno v:
Molecular Cancer, Vol 19, Iss 1, Pp 1-16 (2020)
Abstract Background Although both circular RNAs (circRNAs) and autophagy are associated with the function of breast cancer (BC), whether circRNAs regulate BC progression via autophagy remains unknown. In this study, we aim to explore the regulatory m
Externí odkaz:
https://doaj.org/article/35fa6be6278d41d1b64faf58fef71b0d
Autor:
Gehao Liang, Yun Ling, Qun Lin, Yu Shi, Qing Luo, Yinghuan Cen, Maryam Mehrpour, Ahmed Hamai, Jun Li, Chang Gong
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
ObjectivesCircular RNA (circRNA) is a novel class of RNA, which exhibits powerful biological function in regulating cellular fate of various tumors. Previously, we had demonstrated that over-expression of circRNA circCDYL promoted progression of HER2
Externí odkaz:
https://doaj.org/article/a45068c524464df6a35337ad65acd068
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Background: Ferroptosis, a regulated cell death which is driven by the iron-dependent peroxidation of lipids, plays an important role in cancer. However, studies about ferroptosis-related Long non-coding RNAs (lncRNAs) in breast cancer (BC) are limit
Externí odkaz:
https://doaj.org/article/a78d858abdf94e6d9f475cc12c6c4f09
Autor:
Yi Ding, Chang Gong, De Huang, Rui Chen, Pinpin Sui, Kevin H. Lin, Gehao Liang, Lifeng Yuan, Handan Xiang, Junying Chen, Tao Yin, Peter B. Alexander, Qian-Fei Wang, Er-Wei Song, Qi-Jing Li, Kris C. Wood, Xiao-Fan Wang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Resistance to anti-HER2 therapy in breast cancer remains a major obstacle in the clinic. Here the authors performed a CRISPR-selective vulnerability screen to identify transaldoloase as a target that is synthetically lethal with HER2 inhibition in br
Externí odkaz:
https://doaj.org/article/3b4653d4e9534695875c3adfe802cb21
Autor:
Chang Gong, Weige Tan, Kai Chen, Na You, Shan Zhu, Gehao Liang, Xinhua Xie, Qian Li, Yunjie Zeng, Nengtai Ouyang, Zhihua Li, Musheng Zeng, ShiMei Zhuang, Wan-Yee Lau, Qiang Liu, Dong Yin, Xueqin Wang, Fengxi Su, Erwei Song
Publikováno v:
EBioMedicine, Vol 11, Iss C, Pp 199-209 (2016)
Purpose: Breast cancer patients with high proportion of cancer stem cells (BCSCs) have unfavorable clinical outcomes. MicroRNAs (miRNAs) regulate key features of BCSCs. We hypothesized that a biology-driven model based on BCSC-associated miRNAs could
Externí odkaz:
https://doaj.org/article/a7a8ea49c799469f8695c6c305de124d
Autor:
Wanyi Lin, Zihao Liu, Zhenluan Tian, Qing Luo, Gehao Liang, Yaping Yang, Chang Gong, Yun Ling, Nanyan Rao, Qun Lin, Wenjing Zhong
Publikováno v:
Cancer Management and Research
Wanyi Lin,1,2,* Yaping Yang,1,2,* Wenjing Zhong,1,2 Qun Lin,1,2 Nanyan Rao,1– 3 Gehao Liang,1,2 Yun Ling,1,2 Zihao Liu,1,2 Qing Luo,1,2 Zhenluan Tian,1,2 Chang Gong1,2,4 1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene R