Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Gefei, Guan"'
Autor:
Shuai Shen, Xing Liu, Qing Guo, Qingyu Liang, Jianqi Wu, Gefei Guan, Cunyi Zou, Chen Zhu, Zihao Yan, Tianqi Liu, Ling Chen, Peng Cheng, Wen Cheng, Anhua Wu
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
Abstract Epithelial-mesenchymal transition (EMT) is a common process during tumor progression and is always related to residual tumor, drug resistance and immune suppression. However, considering the heterogeneity in EMT process, there is still a nee
Externí odkaz:
https://doaj.org/article/c309d85d8f464f4ab1e2d0a23ab7877b
Autor:
Xin Chen, Tianqi Liu, Jianqi Wu, Chen Zhu, Gefei Guan, Cunyi Zou, Qing Guo, Xiaolin Ren, Chen Li, Peng Cheng, Wen Cheng, Anhua Wu
Publikováno v:
JCI Insight, Vol 7, Iss 23 (2023)
Tumor protein 53 mutation (TP53mut) is one of the most important driver events facilitating tumorigenesis, which could induce a series of chain reactions to promote tumor malignant transformation. However, the malignancy progression patterns under TP
Externí odkaz:
https://doaj.org/article/b26d251db59b421da45b7485f6431d93
Autor:
Tianqi Liu, Chen Zhu, Xin Chen, Jianqi Wu, Gefei Guan, Cunyi Zou, Shuai Shen, Ling Chen, Peng Cheng, Wen Cheng, Anhua Wu
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
The tumor microenvironment (TME) plays a critical role in promoting the growth and metastasis of glioblastoma (GBM). Tumor-associated macrophages (TAMs), the most abundant myeloid cells infiltrating in TME, produce proinflammatory cytokines, regulate
Externí odkaz:
https://doaj.org/article/155484fd6fa841059763d5024f0fefc1
Autor:
Qing Guo, Shuai Shen, Gefei Guan, Chen Zhu, Cunyi Zou, Jingyuan Cao, Wen Cheng, Xiaoyan Xu, Juanhan Yu, Zhiguo Lin, Guoli Wang, Ling Chen, Peng Cheng, Anhua Wu
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105329- (2022)
Summary: Glioblastoma (GBM) is identified to share common signal pathways between glioma and immune cells. Here, we find that T cell immunoglobulin domain and mucin domain protein 3 (TIM-3) is one of the most common co-inhibitory immune checkpoints i
Externí odkaz:
https://doaj.org/article/e4c26c5d345f4809b78c1b6ade3c4fba
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-16 (2020)
Abstract Background Molecular classification has laid the framework for exploring glioma biology and treatment strategies. Pro-neural to mesenchymal transition (PMT) of glioma is known to be associated with aggressive phenotypes, unfavorable prognosi
Externí odkaz:
https://doaj.org/article/2cdab7315f8e48a097e54b41c16a9280
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-15 (2019)
Abstract Background Glioma is the most common primary malignant brain tumor in adults with a poor prognosis. ARL3 is a member of the ARF family, and plays a key role in ciliary function and lipid-modified protein trafficking. ARL3 has been reported t
Externí odkaz:
https://doaj.org/article/c1975c1d9198412f9c22ec253b8f37cc
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Glioma is the most prevalent primary brain tumor in adults and has an extremely unfavorable prognosis. As a member of the lysyl oxidase (LOX) family, lysyl-oxidase-like-2 (LOXL2) is known to play different roles in different tumors. However, the role
Externí odkaz:
https://doaj.org/article/1ca160d39eea444a8f7b353aa4bc9920
Autor:
Shuai Shen, Zihao Yan, Jianqi Wu, Xing Liu, Gefei Guan, Cunyi Zou, Qing Guo, Chen Zhu, Tianqi Liu, Chen Chen, Ling Chen, Peng Cheng, Wen Cheng, Anhua Wu
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Background: Abnormal redox equilibrium is a major contributor to tumor malignancy and treatment resistance. Understanding reactive oxygen species (ROS) metabolism is a key to clarify the tumor redox status. However, we have limited methods to evaluat
Externí odkaz:
https://doaj.org/article/6e9129c81240467dadd969afcd6b018c
Autor:
Yulin Wang, Gefei Guan, Wen Cheng, Yang Jiang, Fengping Shan, Anhua Wu, Peng Cheng, Zongze Guo
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-13 (2018)
Abstract Background Glioma is the most common primary brain tumor in adults with a poor prognosis. As a member of ARF subfamily GTPase, ARL2 plays a key role in regulating the dynamics of microtubules and mitochondrial functions. Recently, ARL2 has b
Externí odkaz:
https://doaj.org/article/764c1e4588224b08a1d67cf1f7bb8551
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Background: Glioma is the most common primary brain tumor with a dismal prognosis. It is urgent to develop novel molecular biomarkers and conform to individualized schemes.Methods: Differentially expressed pseudogenes between low grade glioma (LGG) a
Externí odkaz:
https://doaj.org/article/399e9285bf274af086eba0c3ffda1634