Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Geethu Emily Thomas"'
Autor:
Geethu Emily Thomas, Grace Egan, Laura García-Prat, Aaron Botham, Veronique Voisin, Parasvi S. Patel, Fieke W. Hoff, Jordan Chin, Boaz Nachmias, Kerstin B. Kaufmann, Dilshad H. Khan, Rose Hurren, Xiaoming Wang, Marcela Gronda, Neil MacLean, Cristiana O’Brien, Rashim P. Singh, Courtney L. Jones, Shane M. Harding, Brian Raught, Andrea Arruda, Mark D. Minden, Gary D. Bader, Razq Hakem, Steve Kornblau, John E. Dick, Aaron D. Schimmer
Publikováno v:
Nature Cell Biology, 24(6), 872-884. Nature Publishing Group
Thomas, Egan et al. report that hexokinase 2 localizes to the nucleus of leukaemic and normal haematopoietic cells to maintain stemness by interacting with nuclear proteins and modulating chromatin accessibility independently of its kinase activity.M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c0e3f75e0f74aa55b9b32d6b76b667
https://doi.org/10.1038/s41556-022-00925-9
https://doi.org/10.1038/s41556-022-00925-9
Autor:
Boaz Nachmias, Dilshad H. Khan, Veronique Voisin, Arvind S. Mer, Geethu Emily Thomas, Nadav Segev, Jonathan St-Germain, Rose Hurren, Marcela Gronda, Aaron Botham, Xiaoming Wang, Neil Maclean, Ayesh K. Seneviratne, Nathan Duong, Changjiang Xu, Andrea Arruda, Elias Orouji, Arash Algouneh, Razqallah Hakem, Liran Shlush, Mark D. Minden, Brian Raught, Gary D. Bader, Aaron D. Schimmer
Publikováno v:
Leukemia. 36:1283-1295
AML cells are arranged in a hierarchy with stem/progenitor cells giving rise to more differentiated bulk cells. Despite the importance of stem/progenitors in the pathogenesis of AML, the determinants of the AML stem/progenitor state are not fully und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0436b84cdd1246b5219aec49cf862bd
https://doi.org/10.1038/s41375-022-01513-4
https://doi.org/10.1038/s41375-022-01513-4
Autor:
Geethu Emily Thomas, Kazem Nouri, Jong Bok Lee, Rose Hurren, Yongran Yan, Neil MacLean, Yulia Jitkova, Li Ma, Xiao Ming Wang, Chaitra Sarathy, Andrea Arruda, Mark D. Minden, Li Zhang, Vito Spadavecchio, Aaron Schimmer
Publikováno v:
Cancer Research. 83:4833-4833
Eukaryotic cells have two separate genomes; nuclear chromosomal DNA and circular mitochondrial DNA. Mitochondrial DNA lacks introns, and encodes 2 rRNAs, 22 t-RNAs and 13 of the 90 proteins that constitute the mitochondrial respiratory chain. To main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ae573e2d22d2c6682441fe596c63bff
https://doi.org/10.1158/1538-7445.am2023-4833
https://doi.org/10.1158/1538-7445.am2023-4833
Autor:
Geethu Emily Thomas, Kazem Nouri, Rose Hurren, Yongran Yan, Neil MacLean, Yulia Jitkova, Li Ma, Xiaoming Wang, Chaitra Sarathy, Andrea Arruda, Mark D. Minden, Vito Spadevecchio, Aaron D. Schimmer
Publikováno v:
Blood. 140:8723-8724
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::290f056113afdb3ef834ba339390325b
https://doi.org/10.1182/blood-2022-158326
https://doi.org/10.1182/blood-2022-158326
Autor:
Nathan Duong, Dilshad H. Khan, Geethu Emily Thomas, Rose Hurren, Jong Bok Lee, Jonathan St-Germain, Lily Drimmer, Yongran Yan, Neil MacLean, Marcela Gronda, Brandon D Brown, Brian Raught, Andrea Arruda, Mark D. Minden, Li Zhang, Steven M. Kornblau, Vito Spadevecchio, Aaron D. Schimmer
Publikováno v:
Blood. 140:3005-3006
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3680cac5129d60f3cdd6305c1d0fc0f
https://doi.org/10.1182/blood-2022-157626
https://doi.org/10.1182/blood-2022-157626
Autor:
Grace Egan, Rose Hurren, Chaitra Sarathy, Geethu Emily Thomas, Dilshad H. Khan, Yongran Yan, Yue Feng, Brandon Brown, Steven M. Kornblau, Aaron D. Schimmer
Publikováno v:
Blood. 140:11504-11505
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63ca57deea38f3e919bbc25745196c43
https://doi.org/10.1182/blood-2022-157322
https://doi.org/10.1182/blood-2022-157322
Publikováno v:
Biochemical Journal. 474:3559-3577
Chromosome congression and segregation require robust yet dynamic attachment of the kinetochore with the spindle microtubules. Force generated at the kinetochore–microtubule interface plays a vital role to drive the attachment, as it is required to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d6b12f95bedeffe76bdab17acbfeba
https://doi.org/10.1042/bcj20170518
https://doi.org/10.1042/bcj20170518
Autor:
Geethu Emily Thomas, Grace Egan, Laura Garcia Prat, Botham Aaron, Veronique Voisin, Elias Orouji, Jordan M Chin, Boaz Nachmias, Kerstin B Kaufmann, Fieke W Hoff, Neil Maclean, Rose Hurren, Xiaoming Wang, Marcela Gronda, Andrea Arruda, Mark D. Minden, Gary D Bader, Steven M. Kornblau, John E. Dick, Aaron D Schimmer
Publikováno v:
Blood. 136:1-2
Mitochondrial metabolites affect epigenetic marks, but it is largely unknown whether mitochondrial metabolic enzymes can directly localize to the nucleus to regulate stem cell function in AML. Here, we discovered that the mitochondrial enzyme, Hexoki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d170213f2308e6db4524fa95cc399bb3
https://doi.org/10.1182/blood-2020-135858
https://doi.org/10.1182/blood-2020-135858
Autor:
Hindol Gupta, Manidipa Banerjee, K. Bandopadhyay, J. Mitra, Puja Singh, Geethu Emily Thomas, Steny Simon, Raja Paul, Sabyasachi Sutradhar, Tapas Manna, Binshad Badarudeen, M. R. Renjith, K. K. Gireesh
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
Nature Communications
Kinetochore couples chromosome movement to dynamic microtubules, a process that is fundamental to mitosis in all eukaryotes but poorly understood. In vertebrates, spindle-kinetochore-associated (Ska1–3) protein complex plays an important role in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94987026e8a0b1329cc14a17f3493a8a
https://doaj.org/article/f53440769de3492a93c9e28514a15bd5
https://doaj.org/article/f53440769de3492a93c9e28514a15bd5
Autor:
Tapas Manna, Hindol Gupta, Athira George, Binshad Badarudeen, Geethu Emily Thomas, K. K. Gireesh
Publikováno v:
Biochemistry. 54:6413-6422
Centrioles are essential components of the animal centrosome and play crucial roles in the formation of cilia and flagella. They are cylindrical structures composed of nine triplet microtubules organized around a central cartwheel. Recent studies hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc902c7dafcff44e4eb6e847b874565
https://doi.org/10.1021/acs.biochem.5b00978
https://doi.org/10.1021/acs.biochem.5b00978