Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Geethanjali Dornadula"'
Autor:
Xin Tong, Jessica Raffaele, Katrina Feller, Geethanjali Dornadula, James Devlin, David Boyd, John W. Loughney, Jon Shanter, Richard R. Rustandi
Publikováno v:
Vaccines, Vol 12, Iss 2, p 169 (2024)
The development of mRNA vaccines has increased rapidly since the COVID-19 pandemic. As one of the critical attributes, understanding mRNA lipid nanoparticle (LNP) stability is critical in the vaccine product development. However, the correlation betw
Externí odkaz:
https://doaj.org/article/e413cf88202d4ce2be9040503241c1b3
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 63:227-235
Introduction Pharmacokinetic properties of biotherapeutics are an important aspect of preclinical drug development. The lead identification and optimization space is characterized by aggressive timelines, large sample numbers, a variety of species an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5fdba0426f6ff917aa26a719ee4f17
https://doi.org/10.1016/j.vascn.2010.12.002
https://doi.org/10.1016/j.vascn.2010.12.002
Autor:
David S. Thiriot, Jon H. Heinrichs, Geethanjali Dornadula, Bei Wang, Anthony D. Kanavage, Adam Kristopeit, Jeffrey T. Blue, Richard R. Rustandi, Laura Hong, Su Wang, Feng Wang, Henryk Mach, Susan Secore, Christopher D. Mensch
Publikováno v:
Vaccine. 33(1)
The toxicity of Clostridium difficile large clostridial toxin B (TcdB) can be reduced by many orders of magnitude by a combination of targeted point mutations. However, a TcdB mutant with five point mutations (referred to herein as mTcdB) still has r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1235b05b0184c57661606d370f2b1c
https://pubmed.ncbi.nlm.nih.gov/24951860
https://pubmed.ncbi.nlm.nih.gov/24951860
Publikováno v:
Journal of Virology. 74:2594-2602
Virion infectivity factor (Vif) is a protein encoded by human immunodeficiency virus type I (HIV-1) and is essential for viral replication. It appears that Vif functions in the virus-producing cells and affects viral assembly. Viruses with defects in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9faa8ee707136a43cfdc406e17df24ac
https://doi.org/10.1128/jvi.74.6.2594-2602.2000
https://doi.org/10.1128/jvi.74.6.2594-2602.2000
Publikováno v:
Virology. 227:260-267
It has been demonstrated that human immunodeficiency virus type 1 (HIV-1) virions are biochemically active particles, within which reverse transcription can take place even in physiological microenvironments. This process has been termed “natural e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81cb26902fb972091521a42996962930
https://doi.org/10.1006/viro.1996.8317
https://doi.org/10.1006/viro.1996.8317
Publikováno v:
Proceedings of the National Academy of Sciences. 93:12519-12524
Reverse transcription of HIV-1, without detergent or amphipathic peptide-induced permeability of the viral envelope, has been demonstrated to occur in the intact HIV-1 virion. In this report, we demonstrate that the amphipathic domains in the C termi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49db347e2f8a5b96d87d32b91e309bcc
https://doi.org/10.1073/pnas.93.22.12519
https://doi.org/10.1073/pnas.93.22.12519
Publikováno v:
Journal of Virology. 70:2809-2824
Endogenous reverse transcription (ERT) of retroviruses has long been considered a somewhat artificial process which only mimics reverse transcription occurring in target cells, as detergents or amphipathic peptides have classically been used to make
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282bf797f951be7fb1e033313e85ca59
https://doi.org/10.1128/jvi.70.5.2809-2824.1996
https://doi.org/10.1128/jvi.70.5.2809-2824.1996
Autor:
Roger J. Pomerantz, Ketti E. Mehlman, Hui Zhang, Edward Acheampong, Chune Zhang, Elias G. Argyris, Giuseppe Nunnari, Geethanjali Dornadula
In the current study, we extended our previous works on natural endogenous reverse transcription (NERT) and further examined its potential as a virucide molecular target in sexual transmission of primate lentiviruses. HIV-1 and SIV virions were pretr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7358497fd3524af55b7437086dc3680c
https://hdl.handle.net/20.500.11769/552227
https://hdl.handle.net/20.500.11769/552227
Autor:
John A. Young, Shakti Narayan, Michael D. Miller, Richard J. O. Barnard, Geethanjali Dornadula
A novel entry mechanism has been proposed for the avian sarcoma and leukosis virus (ASLV), whereby interaction with specific cell surface receptors activates or primes the viral envelope glycoprotein (Env), rendering it sensitive to subsequent low-pH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc033430e4661ba8c33f5d0fc08e0c8
https://europepmc.org/articles/PMC516436/
https://europepmc.org/articles/PMC516436/
Autor:
Daria J. Hazuda, John S. Wai, Lynda Tussey, Neville J. Anthony, Geethanjali Dornadula, Michael D. Miller, John W. Shiver, Joseph P. Vacca, Sherri L. Motzel, Lixia Jin, Robert M. Danovich, Marc V. Witmer, Larry Handt, James P. Guare, Danilo R. Casimiro, Steven D. Young, Lori S. Gabryelski, Hilton J. Klein, Robert P. Gomez, Keith A. Wilson, William A. Schleif, Emilio A. Emini
Publikováno v:
Science (New York, N.Y.). 305(5683)
We describe the efficacy of L-870812, an inhibitor of HIV-1 and SIV integrase, in rhesus macaques infected with the simian-human immunodeficiency virus (SHIV) 89.6P. When initiated before CD4 cell depletion, L-870812 therapy mediated a sustained supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d00fdcc48d33695f331e19fc6a1f349
https://pubmed.ncbi.nlm.nih.gov/15247437
https://pubmed.ncbi.nlm.nih.gov/15247437