Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Geetha Velmourougane"'
Autor:
Michael Klemba, Geetha Velmourougane, Seema Dalal, Doron C. Greenbaum, Nataline Meinhardt, Michael B. Harbut, Sheena McGowan, James C. Whisstock, Christine A Oellig
Publikováno v:
Journal of Medicinal Chemistry. 54:1655-1666
The malarial PfA-M1 metallo-aminopeptidase is considered a putative drug target. The natural product dipeptide mimetic, bestatin, is a potent inhibitor of PfA-M1. Herein we present a new, efficient, and high-yielding protocol for the synthesis of bes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de4cd1f54ccf6faec17095997b56f2e9
https://doi.org/10.1021/jm101227t
https://doi.org/10.1021/jm101227t
Autor:
Rajesh Chandramohanadas, Peter A. Greer, Paul H. Davis, Michael B. Harbut, Geetha Velmourougane, Doron C. Greenbaum, David S. Roos, Claire Darling, Daniel P. Beiting, Ming Yeh Lee
Publikováno v:
Science. 324:794-797
Let Me Out Apicomplexan parasites like Plasmodium falciparum , which causes malaria, and Toxoplasma gondii , which cause toxoplasmosis, replicate inside animal host cells. In order for infections to spread successfully within the host from cell to ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::434e0829be907072ddbcc281f1c39d33
https://doi.org/10.1126/science.1171085
https://doi.org/10.1126/science.1171085
Autor:
Geetha Velmourougane, Gilana Reiss, Doron C. Greenbaum, Rajesh Chandramohanadas, Michael B. Harbut
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5932-5936
A novel set of activity-based probes (ABPs) for functionally profiling metallo-aminopeptidases was synthesized based on the bestatin inhibitor scaffold, the first synthesis of bestatin analogues using solid-phase techniques. These ABPs were shown to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7d16b0a28e00e6f04a5c8687043f608
https://doi.org/10.1016/j.bmcl.2008.09.021
https://doi.org/10.1016/j.bmcl.2008.09.021
Autor:
James C. Whisstock, Geetha Velmourougane, Dustin Brisson, Michael Klemba, Michael B. Harbut, Özlem Önder, Sheena McGowan, Gilana Reiss, Doron C. Greenbaum, Seema Dalal
Malaria causes worldwide morbidity and mortality, and while chemotherapy remains an excellent means of malaria control, drug-resistant parasites necessitate the discovery of new antimalarials. Peptidases are a promising class of drug targets and perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a9637404f370af9c938a136fd280f8
https://hdl.handle.net/10453/116122
https://hdl.handle.net/10453/116122
Autor:
Gabriel Bricard, Amy R. Howell, Gurdyal S. Besra, Steven A. Porcelli, Ravinder Raju, Jin S. Im, Geetha Velmourougane
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(13)
An alpha-galactosyl ceramide (alpha-GalCer) 2 was synthesized and evaluated for its ability to stimulate iNKT-cell proliferation and elicit T-helper cytokines, IL-4 and IFNgamma. Compound 2 combines the acyl chain of the potent, Th2 biasing alpha-Gal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53182f8dfeb0901f9c9278bcee6e8f24
https://pubmed.ncbi.nlm.nih.gov/19481452
https://pubmed.ncbi.nlm.nih.gov/19481452
Autor:
Geetha Velmourougane, Michael B. Harbut, Seema Dalal, Sheena McGowan, Christine A. Oellig, Nataline Meinhardt, James C. Whisstock, Michael Klemba, Doron C. Greenbaum
Publikováno v:
Journal of Medicinal Chemistry; Mar2011, Vol. 54 Issue 6, p1655-1666, 12p