Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Geetha, Rao"'
Autor:
Simon J. Pelham, Maria Soledad Caldirola, Danielle T. Avery, Joseph Mackie, Geetha Rao, Florian Gothe, Timothy J. Peters, Antoine Guerin, David Neumann, Doris Vokurkova, Vivian Hwa, Wenming Zhang, Shu-Chen Lyu, Iris Chang, Monali Manohar, Kari C. Nadeau, Maria Isabel Gaillard, Liliana Bezrodnik, Violeta Iotova, Norberto Walter Zwirner, Mavel Gutierrez, Waleed Al-Herz, Christopher C. Goodnow, Alexander Vargas-Hernández, Lisa R. Forbes Satter, Sophie Hambleton, Elissa K. Deenick, Cindy S. Ma, Stuart G. Tangye
Publikováno v:
Journal of Allergy and Clinical Immunology. 150:931-946
Lymphocyte differentiation is regulated by coordinated actions of cytokines and signaling pathways. IL-21 activates STAT1, STAT3, and STAT5 and is fundamental for the differentiation of human B cells into memory cells and antibody-secreting cells. Wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f1417bb6e8b95ace14224a6883f8bb
https://doi.org/10.1016/j.jaci.2022.04.011
https://doi.org/10.1016/j.jaci.2022.04.011
Autor:
Etienne, Masle-Farquhar, Katherine J L, Jackson, Timothy J, Peters, Ghamdan, Al-Eryani, Mandeep, Singh, Kathryn J, Payne, Geetha, Rao, Danielle T, Avery, Gabrielle, Apps, Jennifer, Kingham, Christopher J, Jara, Ksenia, Skvortsova, Alexander, Swarbrick, Cindy S, Ma, Daniel, Suan, Gulbu, Uzel, Ignatius, Chua, Jennifer W, Leiding, Kaarina, Heiskanen, Kahn, Preece, Leena, Kainulainen, Michael, O'Sullivan, Megan A, Cooper, Mikko R J, Seppänen, Satu, Mustjoki, Shannon, Brothers, Tiphanie P, Vogel, Robert, Brink, Stuart G, Tangye, Joanne H, Reed, Christopher C, Goodnow
Publikováno v:
Immunity. 55(12)
The association between cancer and autoimmune disease is unexplained, exemplified by T cell large granular lymphocytic leukemia (T-LGL) where gain-of-function (GOF) somatic STAT3 mutations correlate with co-existing autoimmunity. To investigate wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9a5e36bac887eaf28971fb939b102fa8
https://pubmed.ncbi.nlm.nih.gov/36446385
https://pubmed.ncbi.nlm.nih.gov/36446385
Autor:
Etienne Masle-Farquhar, Katherine J.L. Jackson, Timothy J. Peters, Ghamdan Al-Eryani, Mandeep Singh, Kathryn J. Payne, Geetha Rao, Gabrielle Apps, Jennifer Kingham, Christopher J. Jara, Ksenia Skvortsova, Alexander Swarbrick, Cindy S. Ma, Daniel Suan, Gulbu Uzel, Ignatius Chua, Jennifer W. Leiding, Kaarina Heiskanen, Kahn Preece, Leena Kainulainen, Michael O’Sullivan, Megan A. Cooper, Mikko R.J. Seppänen, Satu Mustjoki, Shannon Brothers, Tiphanie P. Vogel, Robert Brink, Stuart G. Tangye, Joanne H. Reed, Christopher C. Goodnow
SUMMARYThe association between cancer and autoimmune disease is unexplained, exemplified by T-cell large granular lymphocytic leukemia (T-LGL) where gain-of-function somatic mutations inSTAT3correlate with co-existing autoimmunity. To resolve whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f8f08b917b93ea3f879bbfce82dd0b8
https://doi.org/10.1101/2022.02.11.480027
https://doi.org/10.1101/2022.02.11.480027
Autor:
Ingrid C. Gelissen, Laura J. Sharpe, Cecilia Sandoval, Geetha Rao, Maaike Kockx, Leonard Kritharides, Wendy Jessup, Andrew J. Brown
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 10, Pp 2133-2140 (2012)
ABCG1 is an ABC half-transporter that exports cholesterol from cells to HDL. This study set out to investigate differences in posttranslational processing of two human ABCG1 protein isoforms, termed ABCG1(+12) and ABCG1(− 12), that differ by the pr
Externí odkaz:
https://doaj.org/article/c990d1183fe34e0abe873d41cfb2cd10
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 11, Pp 946-956 (2010)
Heparanase-1 (HPR1), an endoglycosidase that specifically degrades heparan sulfate (HS) proteoglycans, is overexpressed in a variety of malignancies. Our present study sought to determine whether oncogene BRAF and RAS mutations lead to increased HPR1
Externí odkaz:
https://doaj.org/article/9a7d920709ce4d8e9ea35f511706786a
Autor:
Rui Yang, Rubén Martínez-Barricarte, Janet Markle, Franck Rapaport, Stuart G. Tangye, Mathieu Bourgey, David Langlais, Anne Puel, Aziz Belkadi, Masato Ogishi, Simon J. Pelham, Jean-Laurent Casanova, Bertrand Boisson, Cindy S. Ma, Vivien Béziat, Eman Abou Moussa, Jérémie Rosain, Laurent Abel, Tomi Lazarov, Serkan Belkaya, Fatima Ailal, Ibtihal Benhsaien, Coralie Briand, Alessandro Plebani, Romain Lévy, Frederic Geissmann, Caroline Deswarte, Andrea Guennoun, Luis R. Saraiva, Tanwir Habib, Mehdi Emam, Vassilios Lougaris, Philippe Gros, Yu Jerry Zhou, Ahmed Aziz Bousfiha, Geetha Rao, Kathryn Payne, Sylvain Breton, Ai Ing Lim, Kang Liu, Kunihiko Moriya, Danielle T. Avery, Bénédicte Neven, Nico Marr, Jacinta Bustamante, Mélanie Migaud, James P. Di Santo
Publikováno v:
J Clin Invest
We studied a child with severe viral, bacterial, fungal, and parasitic diseases, who was homozygous for a loss-of-function mutation of REL, encoding c-Rel, which is selectively expressed in lymphoid and myeloid cells. The patient had low frequencies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340b844d531f310481ac6853ba786de0
https://doi.org/10.1172/jci150143
https://doi.org/10.1172/jci150143
Autor:
Henrik Molina, Vivien Béziat, Alain Lefevre-Utile, Marie-Olivia Chandesris, Danielle T. Avery, Maya Chrabieh, Stéphanie Boisson-Dupuis, Anne Puel, Tanwir Habib, Françoise Sarrot-Reynauld, Aziz Belkadi, Hanan Alwaseem, Geetha Rao, Agathe Senechal, Stuart G. Tangye, Qian Zhang, Olivier Lortholary, Bertrand Boisson, Joëlle Khourieh, Xiao-Fei Kong, Capucine Picard, Virginie Grandin, Nico Marr, Jean-Laurent Casanova, Laurent Abel
Publikováno v:
Proceedings of the National Academy of Sciences. 116:16463-16472
Heterozygous in-frame mutations in coding regions of human STAT3 underlie the only known autosomal dominant form of hyper IgE syndrome (AD HIES). About 5% of familial cases remain unexplained. The mutant proteins are loss-of-function and dominant-neg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6fd149df639c39ad42fc571356b2dee
https://doi.org/10.1073/pnas.1901409116
https://doi.org/10.1073/pnas.1901409116
Autor:
Kaan Boztug, Helen Lenthall, Elise French, Anthony Lau, Robert Brink, Kathryn Payne, Michael O'Sullivan, Roshini S. Abraham, Simon J. Pelham, Peter Hsu, Elissa K. Deenick, Paul Gray, Avni Y. Joshi, Luigi D. Notarangelo, Gulbu Uzel, Geetha Rao, Melanie Wong, Joanne Smart, Emily S.J. Edwards, Isabelle Meyts, Theresa Cole, Stuart G. Tangye, Julia Bier, Lucinda J. Berglund, Steven M. Holland, Henry Brigden, Sharon Choo, Cindy S. Ma
Publikováno v:
Journal of Allergy and Clinical Immunology. 144:236-253
BACKGROUND: Gain-of-function (GOF) mutations in PIK3CD cause a primary immunodeficiency characterized by recurrent respiratory tract infections, susceptibility to herpesvirus infections, and impaired antibody responses. Previous work revealed defects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23698067fd39ad7ee7225f022299c50d
https://doi.org/10.1016/j.jaci.2019.01.033
https://doi.org/10.1016/j.jaci.2019.01.033
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e67895 (2013)
The role of mesenchymal stem cells (MSCs) on breast cancer progression, growth and tumorigenesis remains controversial or unknown. In the present study, we investigated the role of MSCs on breast tumor induction and growth in a clinically relevant so
Externí odkaz:
https://doaj.org/article/7c6a765c5d2b44838dfb7e12ccbdda2d
Autor:
Phillip Wong, Peng Zhang, Geetha Rao, Gaspard Kerner, Bertrand Boisson, Figen Dogu, Matthew Adamow, Taushif Khan, Ilhan Tezcan, Simon J. Pelham, Samuel C. Williams, Cindy S. Ma, Caner Aytekin, Deniz Cagdas, Mahbuba Rahman, Tasuku Honjo, Masato Ogishi, Jean-François Emile, Franck Rapaport, Jérémie Rosain, Conor Gruber, Leena Kainulainen, Nico Marr, Garrett Allington, Ferda O. Hosnut, Scott Drutman, Jedd D. Wolchok, David Langlais, Yuka Nakajima, Matthew D. Hellmann, Laurent Abel, Mathieu Bourgey, Aydan Ikinciogullari, Philippe Gros, Jacinta Bustamante, Wei-Te Lei, Stuart G. Tangye, Jean-Laurent Casanova, Flore Rozenberg, Richard P. Lifton, Fatima Al Ali, Michael S. Glickman, Maya Chrabieh, Stéphanie Boisson-Dupuis, Luigi D. Notarangelo, V. Koneti Rao, Ottavia M. Delmonte, Margaret K. Callahan, Vivien Béziat, Silvia Vilarinho, Dusan Bogunovic, András N Spaan, Tomonori Yaguchi, Kenji Chamoto, Rui Yang
Publikováno v:
Nat Med
The pathophysiology of adverse events following programmed cell death protein 1 (PD-1) blockade, including tuberculosis (TB) and autoimmunity, remains poorly characterized. We studied a patient with inherited PD-1 deficiency and TB who died of pulmon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1226dd5d41bf4bf640f6595d2edda1d8
https://pubmed.ncbi.nlm.nih.gov/34183838
https://pubmed.ncbi.nlm.nih.gov/34183838