Výsledky vyhledávání - "Geetaram Sahu"

Akademický článek

A Novel Therapeutic Approach With Sodium Pyruvate on Vital Signs, Acid–Base, and Metabolic Disturbances in Rats With a Combined Blast and Hemorrhagic Shock

Autor: Biswajit Saha, Geetaram Sahu, Pushpa Sharma

Publikováno v: Frontiers in Neurology, Vol 13 (2022)

BackgroundBlast injuries from improvised explosive devices (IEDs) are known to cause blast traumatic brain injuries (bTBIs), hemorrhagic shock (HS), organ damage, mitochondrial dysfunction, and subsequent free radical production. A pre-citric acid cy

Externí odkaz: https://doaj.org/article/bd4fefb4cdaa477381c92a0dda6df098

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Akademický článek

An intrinsically disordered region of the acetyltransferase p300 with similarity to prion-like domains plays a role in aggregation.

Autor: Alexander Kirilyuk, Mika Shimoji, Jason Catania, Geetaram Sahu, Nagarajan Pattabiraman, Antonio Giordano, Christopher Albanese, Italo Mocchetti, Jeffrey A Toretsky, Vladimir N Uversky, Maria Laura Avantaggiati

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e48243 (2012)

Several human diseases including neurodegenerative disorders and cancer are associated with abnormal accumulation and aggregation of misfolded proteins. Proteins with high tendency to aggregate include the p53 gene product, TAU and alpha synuclein. T

Externí odkaz: https://doaj.org/article/c067c8a4093b425591756a1d7f219772

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Akademický článek

Clinical significance of P53 and Bcl-2 in acute myeloid leukemia patients of Eastern India

Autor: Geetaram Sahu, Rabindra Kumar Jena

Publikováno v: Hematology Reports, Vol 3, Iss 3, Pp e28-e28 (2011)

The frequency of p53 and Bcl-2 protein expression in 100 newly diagnosed and 10 relapsed acute myeloid leukemia (AML) patients was analyzed by immunocytochemistry (ICC). The Kaplan-Meier method was used for univariate and multivariate statistical ana

Externí odkaz: https://doaj.org/article/1197a0ba6bcb4c9fb7d98d22eb8aec6f

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DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR

Autor: Tejaswi Jada, Michael Bukrinsky, Larisa Dubrovsky, Gary L. Simon, Geetaram Sahu, Han Yue, Lin Sun, Mudit Tyagi, Adhikarimayum Lakhikumar Sharma, Sonia Zicari, Alex Ochem

Publikováno v: Oncotarget

Despite reductions in mortality from the use of highly active antiretroviral therapy (HAART), the presence of latent or transcriptionally silent proviruses prevents HIV cure/eradication. We have previously reported that DNA-dependent protein kinase (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f9a785db8b8db2bbe04c62894c68e9
http://europepmc.org/articles/PMC7041937

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DNA-PK facilitates HIV transcription by regulating the activity of RNA polymerase II and the recruitment of transcription machinery at HIV LTR

Autor: Geetaram Sahu, Sonia Zicari, Larisa Dubrovsky, Han Yue, Lin Sun, Mudit Tyagi, Alex Ochem, Michael Bukrinsky, Gary L. Simon, Tejaswi Jada

Despite the use of highly effective antiretroviral therapy (HAART), the presence of latent or transcriptionally silent proviruses prevents cure and eradication of HIV infection. These transcriptionally silent proviruses are well protected from both t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ddfbae1d81a41a7139fe02c50ee18c2

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SLC25A1, or CIC, is a novel transcriptional target of mutant p53 and a negative tumor prognostic marker

Autor: Ferdinando Palmieri, Vamsi K. Kolukula, Anju Preet, Maria Laura Avantaggiati, Olga Rodriguez, Gabriella D'Orazi, Geetaram Sahu, Chris Albanese, Vito Iacobazzi, Anton Wellstein

Publikováno v: Oncotarget
ResearcherID
Scopus-Elsevier

// Vamsi K. Kolukula 1 , Geetaram Sahu 1 , Anton Wellstein 1 , Olga C. Rodriguez 1 , Anju Preet 1 , Vito Iacobazzi 2 , Gabriella D’Orazi 3,4 , Chris Albanese 1,* , Ferdinando Palmieri 2,* , and Maria Laura Avantaggiati 1,* . 1 Department of Oncolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f80e74f656c4df5835d50b4cdd8d3d4
http://europepmc.org/articles/PMC4012738

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Restoration of DNA-binding and growth-suppressive activity of mutant forms of p53 via a PCAF-mediated acetylation pathway

Autor: Vamsi K. Kolukula, Jason Catania, Adolf Graessmann, Michael J. Pishvaian, Christopher Albanese, Daniel L. Stoler, Chad D. Knights, Geetaram Sahu, Ricardo E. Perez, Maria Laura Avantaggiati, Vasily Ogryzko

Publikováno v: Journal of Cellular Physiology. 225:394-405

Tumor-derived mutant forms of p53 compromise its DNA binding, transcriptional, and growth regulatory activity in a manner that is dependent upon the cell-type and the type of mutation. Given the high frequency of p53 mutations in human tumors, reacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f612ee1881b74b578c93fcaa26ccfc
https://doi.org/10.1002/jcp.22285

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p53 Binding to Nucleosomal DNA Depends on the Rotational Positioning of DNA Response Element

Autor: Ettore Appella, Difei Wang, Rodney E. Harrington, Gordon L. Hager, Geetaram Sahu, Claudia B. Chen, Victor B. Zhurkin, Akhilesh K. Nagaich

Publikováno v: Journal of Biological Chemistry. 285:1321-1332

The sequence-specific binding to DNA is crucial for the p53 tumor suppressor function. To investigate the constraints imposed on p53-DNA recognition by nucleosomal organization, we studied binding of the p53 DNA binding domain (p53DBD) and full-lengt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9433818d9fdcb5e89d0e0a25b84e34
https://doi.org/10.1074/jbc.m109.081182

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