Výsledky vyhledávání - "Geeta Yalamanchi"

Integrating Intramolecular Hydrogen Bonding (IMHB) Considerations in Drug Discovery Using ΔlogP As a Tool

Autor: Mark S. Plummer, Geeta Yalamanchi, Laurence Philippe, Thomas N. O'Connell, Giulia Caron, Gilles H. Goetz, Kathleen A. Farley, Michael J. Shapiro, Marina Shalaeva, Yuriy A. Abramov

This study demonstrates that ΔlogP(oct-tol) (difference between logP(octanol) and logP(toluene)) describes compounds propensity to form intramolecular hydrogen bonds (IMHB) and may be considered a privileged molecular descriptor for use in drug disc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778f06be28304a9c567ff262c42b3991
http://hdl.handle.net/2318/143547

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An asymmetric synthesis of (2S,5S)-5-substituted azepane-2-carboxylate derivatives

Autor: Hardwin O'dowd, Katherine E. Brighty, Michael W. Fichtner, Donn G. Wishka, Goss S. Kauffman, Mark C. Noe, Marion Bédard, Jason G. Lewis, Richard A. Buzon, Brian Samas, Jaap Kooistra, Ivan J. Samardjiev, Kathleen A. Farley, Geeta Yalamanchi

Publikováno v: The Journal of organic chemistry. 76(6)

To facilitate a drug discovery project, we needed to develop a robust asymmetric synthesis of (2S,5S)-5-substituted-azepane-2-carboxylate derivatives. Two key requirements for the synthesis were flexibility for elaboration at C5 and suitability for l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0679bee29b243873ab7356ff8fde330
https://pubmed.ncbi.nlm.nih.gov/21275376

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Cardiac rate normalization in chronic atrial fibrillation: comparison of long-term efficacy of treatment with amiodarone versus AV node ablation and permanent His-bundle pacing

Autor: Algimantas, Kirkutis, Ausrius, Poviliŭnas, Pasaka, Griciene, Sotir, Polena, Stephen, Yang, Geeta, Yalamanchi, Jonas, Gintautas

Publikováno v: Proceedings of the Western Pharmacology Society. 47

Chronic atrial fibrillation (AF) is a common arrhythmia with significant morbidity and mortality. AF has been the subject of considerable attention and intensive clinical research in recent years. Current opinion on the management of AF favors the re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cbdc9effe3e84ecf85f7dc4a9bcf92a6
https://pubmed.ncbi.nlm.nih.gov/15633616

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