Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Geeta Kala"'
Autor:
Leif Hertz, Geeta Kala
Publikováno v:
Neurochemistry International. 47:4-12
Ammonia exerts a multitude of metabolic and non-metabolic effects on brain tissue. In the present communication we have investigated its effect on lactate production rates, pyruvate production rates and pyruvate/lactate ratios in mouse cerebrocortica
Autor:
Michael W. Lieberman, Andrew A. Bahler, Subbarao V. Kala, Stephen E. Welty, Roberto Barrios, Geeta Kala, Zheng Zheng Shi, Ching Nan Ou, Amy L. Wiseman
Publikováno v:
Lung. 179:319-330
We used mice with a targeted disruption in g-glutamyl transpeptidase (GGT-deficient mice) to study the role of glutathione (GSH) in protection against oxygen-induced lung injury. These mice had reduced levels of lung GSH and restricted ability to syn
Autor:
Donna W. Atwood, Matthew W. Neely, Christopher I. Prater, Michael W. Lieberman, Jeffrey S. Rice, Subbarao V. Kala, Geeta Kala
Publikováno v:
Journal of Biological Chemistry. 275:33404-33408
Worldwide, millions of people are exposed to arsenic in drinking water that exceeds the World Health Organization standard of 10 microg/liter by as much as 50-300-fold, yet little is known about the molecular basis for arsenic excretion. Here we show
Autor:
Zheng Zheng Shi, Geetha M. Habib, Michael W. Lieberman, Subbarao V. Kala, Geeta Kala, Ching Nan Ou
Publikováno v:
Hepatology. 32:556-562
We used mice deficient in γ-glutamyl transpeptidase (GGT) to analyze the effects of GGT deficiency and altered thiol levels on gene expression in liver. GGT-deficient mice have markedly reduced levels of glutathione (GSH), cysteine, methionine, and
Autor:
Roberto Barrios, Geeta Kala, Ching Nan Ou, Michael W. Lieberman, Subbarao V. Kala, Ernest D. Lykissa
Publikováno v:
Environmental Health Perspectives
To examine the toxicity of cyclosiloxanes (CSs), the predominant low molecular weight cyclic silicones found in breast implants, we injected female CD-1 mice intraperitoneally with different doses of distillate (3.5-35 g/kg body weight) containing cy
Publikováno v:
Developmental Brain Research. 82:62-68
The effect of ‘simulated ischemia’, i.e., combined anoxia and substrate deprivation, was studied in 1- and 3-week-old (i.e., immature and mature) primary cultures of mouse astrocytes. Cell survival, as indicated by retention of the high-molecular
Publikováno v:
Neurochemical Research. 19:257-265
Accumulation of radioactivity was studied in primary cultures of mouse astrocytes as a function of time of exposure (4-60 min) to 50 microM glutamate and 200 microM glutamine (initial concentrations), of which either glutamate or glutamine was 14C-la
Autor:
Scott M. Smith, Geeta Kala, Sara R. Zwart, Jane M. Krauhs, J. Vernell Fesperman, Karen L. Ericson, Susan A. Mathews Oliver
Publikováno v:
Aviation, space, and environmental medicine. 80
Introduction: Bed rest is a valuable ground-based model for many of the physiological changes that are associated with spaceflight. Nutritional changes during and after 60 or 90 d of head-down bed rest were evaluated. Methods: A total of 13 subjects
Publikováno v:
The Journal of nutrition. 139(1)
The National Aeronautics and Space Administration Extreme Environment Mission Operations (NEEMO) underwater habitat is a useful analogue for spaceflight. However, the increased air pressure in the habitat exposes crewmembers to higher oxygen pressure
Autor:
Leif Hertz, Geeta Kala
Publikováno v:
Metabolic brain disease. 22(3-4)
Both neurons and astrocytes have high rates of glucose utilization and oxidative metabolism. Fully 20% of glucose consumption is used for astrocytic production of glutamate and glutamine, which during intense glutamatergic activity leads to an increa