Výsledky vyhledávání - "Geet Kumar Nagar"

Fasciola helminth defense molecule‐1 protects against experimental arthritis by inhibiting osteoclast formation and function without modulating the systemic immune response

Autor: Mahesh Chandra Tiwari, Naibedya Chattopadhyay, Shailendra Kumar Maurya, Yasir Akhtar Khan, Geet Kumar Nagar, Chirag Kulkarni

Publikováno v: The FASEB Journal. 34:1091-1106

An inverse correlation between helminth infection and the autoimmune disease appears to be contributed by the anti-inflammatory factors produced by these organisms. Suppressing osteoclast function without affecting the systemic immunological response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc09629696c067360677fd107bd9bf7
https://doi.org/10.1096/fj.201901480rr

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Caviunin glycoside (CAFG) from Dalbergia sissoo attenuates osteoarthritis by modulating chondrogenic and matrix regulating proteins

Autor: Rakesh Maurya, Divya Rai, Aboli Girme, Geet Kumar Nagar, Ritu Trivedi, Ashish Kumar Tripathi, Priyanka Kothari, Shradha Sinha, Dharmendra Choudhary, Ruchi Singh, Lal Hingorani

Publikováno v: Journal of Ethnopharmacology. 282:114315

Ethnopharmacological relevance Dalbergia sissoo DC. (Indian rosewood or Sheesham) is a traditional medicinal plant, reported since time immemorial for its analgesic, anti-nociceptive, anti-inflammatory, and immuno-modulatory properties. D. sissoo DC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da0a04c9b4f4d8a60067ef52819abd2
https://doi.org/10.1016/j.jep.2021.114315

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Influence of antifertility agents Dutasteride and Nifedipine on CatSper gene level in epididymis during sperm maturation in BALB/c mice

Autor: Archana Srivastav, Bendangla Changkija, F. W. Bansode, Geet Kumar Nagar, Kunal Sharan

Publikováno v: Reproduction. 155:347-359

Calcium (Ca2+) signaling is critical for successful fertilization. In spermatozoa, capacitation, hyperactivation of motility and the acrosome reaction are all mediated by increases in intracellular Ca2+ through CatSper (sperm-specific cation channel)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::345615b6da60d8fef56fad9411191024
https://doi.org/10.1530/rep-17-0664

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Formononetin, an isoflavone, activates AMP-activated protein kinase/β-catenin signalling to inhibit adipogenesis and rescues C57BL/6 mice from high-fat diet-induced obesity and bone loss

Autor: Preety Dixit, Geet Kumar Nagar, Rakesh Maurya, Divya Singh, Vikram Khedgikar, Dharmendra Choudhary, Jyoti Gautam, Priyanka Kushwaha, Kapil Dev, Ritu Trivedi

Publikováno v: British Journal of Nutrition. 117:645-661

Balance between adipocyte and osteoblast differentiation is the key link of disease progression in obesity and osteoporosis. We have previously reported that formononetin (FNT), an isoflavone extracted fromButea monosperma, stimulates osteoblast form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a33a8017eef90b627f2ed2fd9ba3ce
https://doi.org/10.1017/s0007114517000149

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Odanacatib Restores Trabecular Bone of Skeletally Mature Female Rabbits With Osteopenia but Induces Brittleness of Cortical Bone: A Comparative Study of the Investigational Drug With PTH, Estrogen, and Alendronate

Autor: Abhishek Singh, Atul Kumar Singh, Himangshu K. Bora, Mohd Parvez Khan, Venkitanarayanan Parameswaran, Jayesh R. Bellare, Naibedya Chattopadhyay, Pragya Shrivastava, Sabyasachi Sanyal, Mahesh Chandra Tiwari, Geet Kumar Nagar

Publikováno v: Journal of Bone and Mineral Research. 31:615-629

Cathepsin K (CK), a lysosomal cysteine protease, is highly expressed in mature osteoclasts and degrades type 1 collagen. Odanacatib (ODN) is a selective and reversible CK inhibitor that inhibits bone loss in preclinical and clinical studies. Although

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c0641dc009f9223fe96cc2d71482a0d
https://doi.org/10.1002/jbmr.2719

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M2 polarization of macrophages by Oncostatin M in hypoxic tumor microenvironment is mediated by mTORC2 and promotes tumor growth and metastasis

Autor: Varsha Singh, Mohammad Asif, Khemraj Singh Baghel, Richa Shrivastava, Naibedya Chattopadhyay, Brij Nath Tewari, Parul Dubey, Smrati Bhadauria, Mehraj-U-Din Lone, Geet Kumar Nagar, Showkat Ahmad Malik, Subhashis Pal

Publikováno v: Cytokine. 118

Oncostatin M (OSM), an inflammatory cytokine belonging to the interleukin-6 (IL-6) superfamily, plays a vital role in multitude of physiological and pathological processes. Its role in breast tumor progression and metastasis to distant organs is well

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147f4be4f1d26f7de57d490ec339b160
https://pubmed.ncbi.nlm.nih.gov/29625858

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Heartwood extract from Dalbergia sissoo promotes fracture healing and its application in ovariectomy-induced osteoporotic rats

Autor: Priyanka Kothari, Ashwni Verma, Naseer Ahmad, Prabhat Ranjan Mishra, Vikram Khedgikar, Priyanka Kushwaha, Ritu Trivedi, Rakesh Maurya, Padam Praveen Kumar, Geet Kumar Nagar, Anirudha Karvande

Publikováno v: The Journal of pharmacy and pharmacology. 69(10)

Objectives This study was undertaken to investigate the effects of a heartwood ethanolic extract (HEE) made from the Dalbergia sissoo on facture healing and in the prevention of pathological bone loss resulting from estrogen deficiency in ovariectomi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ae80e481cb466f42d514fa02068e11
https://pubmed.ncbi.nlm.nih.gov/28664619

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