Site-Specific Quadruple-Functionalised Antibodies.

Autor: Journeaux T; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Geeson MB; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Murray TV; Biologics Engineering, Oncology R&D, AstraZeneca, Cambridge, UK., Papworth MA; Biologics Engineering, Oncology R&D, AstraZeneca, Cambridge, UK., Gothard M; Analytical Sciences, Biopharmaceutical Development, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Kettle JG; Medicinal Chemistry, Oncology R&D, AstraZeneca, Cambridge, UK., Vasco AV; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Bernardes GJL; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Oct 18, pp. e202417620. Date of Electronic Publication: 2024 Oct 18.

The interaction between NLRP1 and oxidized TRX1 involves a transient disulfide bond.

Autor: Geeson MB; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Hsiao JC; Pharmacology Program of the Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Tsamouri LP; Pharmacology Program of the Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Ball DP; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Bachovchin DA; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Pharmacology Program of the Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: bachovcd@mskcc.org.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2024 May 16; Vol. 31 (5), pp. 955-961.e4. Date of Electronic Publication: 2024 Jan 11.

Synthesis of phosphiranes via organoiron-catalyzed phosphinidene transfer to electron-deficient olefins.

Autor: Xin T; Department of Chemistry, Massachusetts Institute of Technology Cambridge MA 02139 USA ccummins@mit.edu., Geeson MB; Department of Chemistry, Massachusetts Institute of Technology Cambridge MA 02139 USA ccummins@mit.edu., Zhu H; Mulliken Center for Theoretical Chemistry, University of Bonn Beringstr. 4 53115 Bonn Germany qu@thch.uni-bonn.de., Qu ZW; Mulliken Center for Theoretical Chemistry, University of Bonn Beringstr. 4 53115 Bonn Germany qu@thch.uni-bonn.de., Grimme S; Mulliken Center for Theoretical Chemistry, University of Bonn Beringstr. 4 53115 Bonn Germany qu@thch.uni-bonn.de., Cummins CC; Department of Chemistry, Massachusetts Institute of Technology Cambridge MA 02139 USA ccummins@mit.edu.

Publikováno v: Chemical science [Chem Sci] 2022 Oct 14; Vol. 13 (43), pp. 12696-12702. Date of Electronic Publication: 2022 Oct 14 (Print Publication: 2022).

Photochemical Alkene Hydrophosphination with Bis(trichlorosilyl)phosphine.

Autor: Geeson MB; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Tanaka K; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Taakili R; Department of Chemical and Biochemical Sciences - Green Process Engineering, Mohammed VI Polytechnic University, Ben Guerir 43150, Morocco.; Institut de Chimie de Nice, UMR7272, Université Côte d'Azur, Nice 06103, France., Benhida R; Department of Chemical and Biochemical Sciences - Green Process Engineering, Mohammed VI Polytechnic University, Ben Guerir 43150, Morocco.; Institut de Chimie de Nice, UMR7272, Université Côte d'Azur, Nice 06103, France., Cummins CC; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2022 Aug 17; Vol. 144 (32), pp. 14452-14457. Date of Electronic Publication: 2022 Aug 04.

Platform for Orthogonal N -Cysteine-Specific Protein Modification Enabled by Cyclopropenone Reagents.

Autor: Istrate A; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom., Geeson MB; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom., Navo CD; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 800, 48160 Derio, Spain., Sousa BB; Instituto de Medicina Molecular, João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal., Marques MC; Instituto de Medicina Molecular, João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal., Taylor RJ; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom., Journeaux T; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom., Oehler SR; Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland., Mortensen MR; Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland., Deery MJ; Cambridge Centre for Proteomics, Gleeson Building, University of Cambridge, Tennis Court Road, CB2 1QR Cambridge, United Kingdom., Bond AD; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom., Corzana F; Departamento de Química, Universidad de La Rioja, Centro de Investigación en Síntesis Química, 26006 Logroño, Spain., Jiménez-Osés G; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 800, 48160 Derio, Spain.; Ikerbasque, Basque Foundation for Science, 48013 Bilbao, Spain., Bernardes GJL; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom.; Instituto de Medicina Molecular, João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2022 Jun 15; Vol. 144 (23), pp. 10396-10406. Date of Electronic Publication: 2022 Jun 05.