Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Geeske M, van Woerden"'
Autor:
Marta Saccher, Shinnosuke Kawasaki, Martina Proietti Onori, Geeske M. van Woerden, Vasiliki Giagka, Ronald Dekker
Publikováno v:
Bioelectronic Medicine, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract Background Microelectrode arrays (MEA) enable the measurement and stimulation of the electrical activity of cultured cells. The integration of other neuromodulation methods will significantly enhance the application range of MEAs to study th
Externí odkaz:
https://doaj.org/article/4d083a9a0f2846e6870aed695619a660
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2023)
IntroductionThe gamma subunit of calcium/calmodulin-dependent protein kinase 2 (CAMK2G) is expressed throughout the brain and is associated with neurodevelopmental disorders. Research on the role of CAMK2G is limited and attributes different function
Externí odkaz:
https://doaj.org/article/c8ae8b579ab542c7bd3bf291ea893f03
Autor:
Pomme M.F. Rigter, Ilse Wallaard, Mehrnoush Aghadavoud Jolfaei, Jenina Kingma, Laura Post, Minetta Elgersma, Ype Elgersma, Geeske M. van Woerden
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105303- (2022)
Summary: With the recent findings that mutations in the gene encoding the α-subunit of calcium/calmodulin-dependent protein kinase II (CAMK2A) causes a neurodevelopmental disorder (NDD), it is of great therapeutic relevance to know if there exists a
Externí odkaz:
https://doaj.org/article/dd5c51f304d94eef9eb2bbf67e5f8829
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Mutations in the genes encoding calcium/calmodulin dependent protein kinase II (CAMK2) isoforms cause a newly recognized neurodevelopmental disorder (ND), for which the full clinical spectrum has yet to be described. Here we report the detailed descr
Externí odkaz:
https://doaj.org/article/9f7edc4829ef4b9a8a52115aa1eb07e9
Publikováno v:
Molecular Autism, Vol 11, Iss 1, Pp 1-12 (2020)
Abstract Background Angelman syndrome (AS) is a rare neurodevelopmental disorder caused by the loss of functional ubiquitin protein ligase E3A (UBE3A). In neurons, UBE3A expression is tightly regulated by a mechanism of imprinting which suppresses th
Externí odkaz:
https://doaj.org/article/b539d1fa5dfd432a9e8a6071f4abe41b
Autor:
Ilaria Tonazzini, Geeske M. Van Woerden, Cecilia Masciullo, Edwin J. Mientjes, Ype Elgersma, Marco Cecchini
Publikováno v:
Molecular Autism, Vol 10, Iss 1, Pp 1-18 (2019)
Abstract Background Although neuronal extracellular sensing is emerging as crucial for brain wiring and therefore plasticity, little is known about these processes in neurodevelopmental disorders. Ubiquitin protein ligase E3A (UBE3A) plays a key role
Externí odkaz:
https://doaj.org/article/58db20dd5da042619a92265d2181039b
Autor:
Monica Sonzogni, Johanna Hakonen, Mireia Bernabé Kleijn, Sara Silva-Santos, Matthew C. Judson, Benjamin D. Philpot, Geeske M. van Woerden, Ype Elgersma
Publikováno v:
Molecular Autism, Vol 10, Iss 1, Pp 1-9 (2019)
Abstract Background Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by mutations affecting UBE3A gene expression. Previous studies in mice revealed distinct critical periods during neurodevelopment in which reactivation of Ube3a
Externí odkaz:
https://doaj.org/article/9f5d993543454a7da9f4c33c367eb2a4
Autor:
Martina Proietti Onori, Linda M C Koene, Carmen B Schäfer, Mark Nellist, Marcel de Brito van Velze, Zhenyu Gao, Ype Elgersma, Geeske M van Woerden
Publikováno v:
PLoS Biology, Vol 19, Iss 5, p e3001279 (2021)
Hyperactivation of the mammalian target of rapamycin (mTOR) pathway can cause malformation of cortical development (MCD) with associated epilepsy and intellectual disability (ID) through a yet unknown mechanism. Here, we made use of the recently iden
Externí odkaz:
https://doaj.org/article/8d4f132af9724879a8c6978f1a598618
Publikováno v:
PLoS Biology, Vol 18, Iss 8, p e3000826 (2020)
Ca2+/calmodulin-dependent kinase II (CaMKII) regulates synaptic plasticity in multiple ways, supposedly including the secretion of neuromodulators like brain-derived neurotrophic factor (BDNF). Here, we show that neuromodulator secretion is indeed re
Externí odkaz:
https://doaj.org/article/a14991662d144e3994c309510d0be9b7
Autor:
Monica Sonzogni, Ilse Wallaard, Sara Silva Santos, Jenina Kingma, Dorine du Mee, Geeske M. van Woerden, Ype Elgersma
Publikováno v:
Molecular Autism, Vol 9, Iss 1, Pp 1-19 (2018)
Abstract Background Angelman syndrome (AS) is a neurodevelopmental disorder caused by mutations affecting UBE3A function. AS is characterized by intellectual disability, impaired motor coordination, epilepsy, and behavioral abnormalities including au
Externí odkaz:
https://doaj.org/article/47ddba8f847a4d07bb0e7241bd603d15