Zobrazeno 1 - 1
of 1
pro vyhledávání: '"Geerwin Hache"'
Autor:
Kristof Van Emelen, Stina Lundgren, Lieven Baert, Jörg K. Wegner, Klara Rombauts, Wim Gaston Verschueren, Daniel Jönsson, Nigel Austin, Åsa Rosenquist, Kevin E. B. Parkes, Jan Willem Thuring, Patrick Sterkens, Wim Van De Vreken, Chantal Masungi, Inge Dierynck, Bart Kesteleyn, Hans Wallberg, Geerwin Hache, Katie Amssoms, Bertil Samuelsson, Bart Stoops, Wim Schepens, Genadiy Kalayanov, Greet Meurs
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(1)
The design and synthesis of novel HIV-1 protease inhibitors (PIs) (1-22), which display high potency against HIV-1 wild-type and multi-PI-resistant HIV-mutant clinical isolates, is described. Lead optimization was initiated from compound 1, a Phe-Phe