Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Geertje Lewin"'
Publikováno v:
Birth Defects Research. 114:812-842
In silico methods for toxicity prediction have increased significantly in recent years due to the 3Rs principle. This also applies to predicting reproductive toxicology, which is one of the most critical factors in pesticide approval. The widely used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30decb9a70ed0e202f512cd861b9a150
https://doi.org/10.1002/bdr2.2062
https://doi.org/10.1002/bdr2.2062
Publikováno v:
Reproductive Toxicology. 104:155-165
Safflower (Carthamus tinctorius) petals have been used for centuries as a spice, in tea blends and in traditional Asian medicine. Aqueous extracts of Safflower petals have been used as a colouring food over the last 30 years due to their bright colou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17812cad8c7d610a790583f54ec72b80
https://doi.org/10.1016/j.reprotox.2021.01.009
https://doi.org/10.1016/j.reprotox.2021.01.009
Autor:
Mark E. Hurtt, Geertje Lewin
Publikováno v:
Birth Defects Research. 109:1519-1539
The purpose of this review is to give an outline of respiratory tract morphological and functional development with an emphasis on perinatal and postnatal maturational processes. In view of the rising need for qualitative and quantitative data for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfaeb53a93007c89674d3f0e51471648
https://doi.org/10.1002/bdr2.1089
https://doi.org/10.1002/bdr2.1089
Autor:
Geertje Lewin
Publikováno v:
Nutrition & Food Science International Journal. 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::042b5f267e383d458a0e60d32be3a34a
https://doi.org/10.19080/nfsij.2018.05.555660
https://doi.org/10.19080/nfsij.2018.05.555660
Publikováno v:
Reproductive Toxicology. 55:81-94
Studies on reproductive toxicity need high numbers of test animals. Therefore, we investigated whether chemical structural features (SF) in combination with in vitro data on specific adverse outcome pathways (AOPs) may be used for predicting reproduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e6cc69b8243f7f11129f30309e5305
https://doi.org/10.1016/j.reprotox.2014.10.009
https://doi.org/10.1016/j.reprotox.2014.10.009
Autor:
Geertje, Lewin, Mark E, Hurtt
Publikováno v:
Birth defects research. 109(19)
The purpose of this review is to give an outline of respiratory tract morphological and functional development with an emphasis on perinatal and postnatal maturational processes. In view of the rising need for qualitative and quantitative data for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fa99259e66e366f078b306d58a2402d4
https://pubmed.ncbi.nlm.nih.gov/28876535
https://pubmed.ncbi.nlm.nih.gov/28876535
Publikováno v:
Toxicology Letters. 226:245-255
Numerous studies on reproductive toxicity are expected to be necessary under the EU program on Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH). Therefore, it is important to analyse existing testing strategies including a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525181b89be56574fe444e52fbf07ad7
https://doi.org/10.1016/j.toxlet.2014.01.045
https://doi.org/10.1016/j.toxlet.2014.01.045
Autor:
Rainer Fuhst, Geertje Lewin, Edith Berger-Preiss, Jochen Buschmann, Heinz-Gerd Hoymann, Gerhard Pohlmann
Publikováno v:
Reproductive Toxicology. 30:422-428
In the context of pharmaceutical development today, studies for pediatric drug approval are requested more and more often by the regulatory authorities. The developing lung represents a potential target in juvenile toxicity studies. Due to physiologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b01aa6cc427a5e2b3511876f15e55c
https://doi.org/10.1016/j.reprotox.2010.05.015
https://doi.org/10.1016/j.reprotox.2010.05.015
Autor:
Stefan Engelhardt, Andrej Safronenko, Simone König, Igor B. Buchwalow, Frank Stümpel, Geertje Lewin, Wilhelm Schmitz, Martin J. Lohse, Sebastian Pius Rohsbach, Marek Matus, Matthias D. Seidl, Abhijit Basu, Frank Müller, Karin Frebel
Publikováno v:
Circulation. 119:79-88
Background— Chronic stimulation of the β 1 -adrenoceptor (β 1 AR) plays a crucial role in the pathogenesis of heart failure; however, underlying mechanisms remain to be elucidated. The regulation by transcription factors cAMP response element-bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae83381a0712f7e8d4ea6f396aec32e7
https://doi.org/10.1161/circulationaha.108.786533
https://doi.org/10.1161/circulationaha.108.786533
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 56
As major immunological and hematological parameters evolve during the early period of life, laboratory data must be interpreted in relation to developmental changes. Wistar (WU) rats were sacrificed on PND2, 4, 7, 10, 14, 17 and 21. Peripheral blood,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ff415059ae437dc8802ea14aa86e29
https://pubmed.ncbi.nlm.nih.gov/26055945
https://pubmed.ncbi.nlm.nih.gov/26055945