Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Geertje J. D. van Mierlo"'
Publikováno v:
Immunobiology, 211(6-8), 627-632. Urban und Fischer Verlag GmbH und Co. KG
Adaptive immune responses are orchestrated by specialized professional antigen-presenting cells (APCs), the dendritic cells (DCs), which play crucial roles as initiators and modulators of adaptive immune responses. A main feature of DCs is their phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd2b441351d85ab48b78affffdcb47c
https://doi.org/10.1016/j.imbio.2006.05.014
https://doi.org/10.1016/j.imbio.2006.05.014
Autor:
René E. M. Toes, Geertje J. D. van Mierlo, Cornelis J. M. Melief, Rienk Offringa, Marieke F. Fransen, Annemieke Th. den Boer
Publikováno v:
Cancer Research. 65:6984-6989
Modulation of the immune response by established tumors may contribute to the limited success of therapeutic vaccination for the treatment of cancer compared with vaccination in a preventive setting. We analyzed the contribution of the CD4+ T-cell po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1023a90590613eb27a436af2a92950d5
https://doi.org/10.1158/0008-5472.can-04-3344
https://doi.org/10.1158/0008-5472.can-04-3344
Autor:
Deirdre Egan, Hélène Dumortier, Rienk Offringa, Willem van Ewijk, Cornelis J. M. Melief, Geertje J. D. van Mierlo, René E. M. Toes
Publikováno v:
The Journal of Immunology. 175:855-863
Immature dendritic cells (DC), in contrast to their mature counterparts, are incapable of mobilizing a CD8+ CTL response, and, instead, have been reported to induce CTL tolerance. We directly addressed the impact of immature vs mature DC on CTL respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c2bae365cc81659491c032dde842c8
https://doi.org/10.4049/jimmunol.175.2.855
https://doi.org/10.4049/jimmunol.175.2.855
Autor:
Hélène Dumortier, René E. M. Toes, Zita F. H. M. Boonman, Ellen I. H. van der Voort, Marieke F. Fransen, Annemieke Th. den Boer, Cornelis J. M. Melief, Geertje J. D. van Mierlo, Jan Nouta, Rienk Offringa
Publikováno v:
The Journal of Immunology. 173:6753-6759
The fate of naive CD8+ T cells is determined by the environment in which they encounter MHC class I presented peptide Ags. The manner in which tumor Ags are presented is a longstanding matter of debate. Ag presentation might be mediated by tumor cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd23a413fa181f85376535299e37d945
https://doi.org/10.4049/jimmunol.173.11.6753
https://doi.org/10.4049/jimmunol.173.11.6753
Autor:
Annemieke Th. den Boer, René E. M. Toes, Marieke F. Fransen, Geertje J. D. van Mierlo, Rienk Offringa, Cornelis J. M. Melief
Publikováno v:
The Journal of Immunology. 172:6074-6079
Naive T cells can be tolerized in the periphery by diverse mechanisms. However, the extent to which memory T cells are susceptible to tolerance induction is less well defined. Vaccination of mice with a minimal CTL epitope derived from human adenovir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7244d14e32227e50a4adc233a21aeb
https://doi.org/10.4049/jimmunol.172.10.6074
https://doi.org/10.4049/jimmunol.172.10.6074
Autor:
René E. M. Toes, Kees L. M. C. Franken, Martine J. Jager, Zita F. H. M. Boonman, Cornelis J. M. Melief, Marieke F. Fransen, Rienk Offringa, Geertje J. D. van Mierlo
Publikováno v:
The Journal of Immunology. 172:1567-1574
Ocular immune privilege is considered essential in the protection against sight-threatening immune responses, as illustrated by the ability of the ocular environment to permit the growth of tumors that are rejected when implanted at other sites. Alth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c532cbf271b4047be1dfdd085bbfe93
https://doi.org/10.4049/jimmunol.172.3.1567
https://doi.org/10.4049/jimmunol.172.3.1567
Autor:
Marieke F. Fransen, Annemieke Th. den Boer, René E. M. Toes, Linda Diehl, Cornelis J. M. Melief, Rienk Offringa, Ellen I. H. van der Voort, Geertje J. D. van Mierlo, Paul Krimpenfort
Publikováno v:
The Journal of Immunology. 167:2522-2528
Encounter of Ag by naive T cells can lead to T cell priming as well as tolerance. The balance between immunity and tolerance is controlled by the conditions of Ag encounter and the activation status of the APC. We have investigated the rules that gov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68228626d57e917085a1c2b3d8952bf8
https://doi.org/10.4049/jimmunol.167.5.2522
https://doi.org/10.4049/jimmunol.167.5.2522
Autor:
Mary E. Morgan, René E. M. Toes, Tom W J Huizinga, Roelof Flierman, Hans Scherer, Marjolijn Hameetman, Geertje J. D. van Mierlo
Publikováno v:
Journal of Immunology, 180, 5, pp. 2747-51
Journal of Immunology, 180, 2747-51
Journal of Immunology, 180, 2747-51
Contains fulltext : 69140.pdf (Publisher’s version ) (Closed access) CD4+CD25+ regulatory T (Treg) cells play an essential role in maintaining tolerance to self and nonself. In several models of T cell-mediated (auto) immunity, Treg cells exert pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59deefa61d865e6c1cfefa358de68ea
https://hdl.handle.net/2066/69140
https://hdl.handle.net/2066/69140
Autor:
Jimmy F.P. Berbée, Nuno Pires, Geertje J D van Mierlo, Louis M. Havekes, Johannes A. Romijn, Robert Kleemann, Marit Westerterp, Patrick C.N. Rensen
Publikováno v:
Circulation, 116(19), 2173-2181. Lippincott Williams and Wilkins
Circulation, 116(19), 2173-2181. LIPPINCOTT WILLIAMS & WILKINS
Circulation, 116(19), 2173-2181. LIPPINCOTT WILLIAMS & WILKINS
Background—Lipopolysaccharide (LPS), which is released from Gram-negative bacteria on multiplication or lysis, aggravates atherosclerosis in humans and rodents by inducing inflammation via toll-like receptors. Because apolipoprotein C-I (apoCI) enh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf01bad3d4ff950a12a13ff530a3b88
https://pure.amc.nl/en/publications/apolipoprotein-ci-is-crucially-involved-in-lipopolysaccharideinduced-atherosclerosis-development-in-apolipoprotein-eknockout-mice(39d0d5f9-7ea1-45bd-ab62-2affaa8aa03f).html
https://pure.amc.nl/en/publications/apolipoprotein-ci-is-crucially-involved-in-lipopolysaccharideinduced-atherosclerosis-development-in-apolipoprotein-eknockout-mice(39d0d5f9-7ea1-45bd-ab62-2affaa8aa03f).html
Autor:
René E. M. Toes, Martine J. Jager, Geertje J. D. van Mierlo, Zita F. H. M. Boonman, Rob J. W. de Keizer, Marieke F. Fransen, Cornelis J. M. Melief
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 175(7)
Ags expressed at immune privileged sites and other peripheral tissues are able to induce T cell tolerance. In this study, we analyzed whether tolerance toward an intraocular tumor expressing a highly immunogenic CTL epitope is maintained, broken, or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8ea2a4f1dbcc9d586538f174adede2
https://pubmed.ncbi.nlm.nih.gov/16177064
https://pubmed.ncbi.nlm.nih.gov/16177064