Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Geerten W Vuister"'
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 11, p e1002794 (2012)
Experimental NMR relaxation studies have shown that peptide binding induces dynamical changes at the side-chain level throughout the second PDZ domain of PTP1e, identifying as such the collection of residues involved in long-range communication. Even
Externí odkaz:
https://doaj.org/article/b45e9c12065541189805d47061b13555
Publikováno v:
PLoS Computational Biology, Vol 2, Iss 2, p e9 (2006)
One of the major goals of structural genomics projects is to determine the three-dimensional structure of representative members of as many different fold families as possible. Comparative modeling is expected to fill the remaining gaps by providing
Externí odkaz:
https://doaj.org/article/bbeca579a53449e48664cf15a49212c3
Autor:
Luca G. Mureddu, Geerten W. Vuister
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Over the last century, the definitions of pharmaceutical drug and drug discovery have changed considerably. Evolving from an almost exclusively serendipitous approach, drug discovery nowadays involves several distinct, yet sometimes interconnected st
Externí odkaz:
https://doaj.org/article/bdcb5c5bfe4a43f0a17a51b5575147d0
Publikováno v:
Journal of Biomolecular Nmr
Fragment-based drug discovery or FBDD is one of the main methods used by industry and academia for identifying drug-like candidates in early stages of drug discovery. NMR has a significant impact at any stage of the drug discovery process, from prima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5681778645469e27f366ebab4ae28e7
https://doi.org/10.1007/s10858-020-00321-1
https://doi.org/10.1007/s10858-020-00321-1
Autor:
Geerten W. Vuister, Luca G. Mureddu
Publikováno v:
The Febs Journal
NMR is one of the major techniques for investigating the structure, dynamics and interactions between biomolecules. However, non-experts often experience NMR experimentation and data analysis as intimidating. We discuss a simple yet powerful NMR tech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e7d0d8de68667657728354a878267e
http://europepmc.org/articles/PMC6563160
http://europepmc.org/articles/PMC6563160
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
The Sin3A complex acts as a transcriptional hub, integrating the function of diverse transcription factors with histone modifying enzymes, notably, histone deacetylases (HDAC) 1 and 2. The Sin3A protein sits at the centre of the complex, mediating mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::decb827077f6214e10c74560b9f72ec5
Autor:
Luca G. Mureddu, Simon P. Skinner, Geerten W. Vuister, Timothy J. Ragan, Rasmus H. Fogh, Wayne Boucher
Publikováno v:
Journal of Biomolecular Nmr
NMR spectroscopy is an indispensably powerful technique for the analysis of biomolecules under ambient conditions, both for structural- and functional studies. However, in practice the complexity of the technique has often frustrated its application
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95edd163e230454c84a019854c38523a
http://europepmc.org/articles/PMC5095159
http://europepmc.org/articles/PMC5095159
Autor:
Neil Bate, John S. Mitcheson, Benjamin T. Goult, Geerten W. Vuister, Simon P. Skinner, Rachel E. Caves, Jaswir Basran
The paralogues TRPV5 and TRPV6 belong to the vanilloid subfamily of the Transient Receptor Potential (TRP) superfamily of ion channels and both play an important role in overall Ca2+ homeostasis. The functioning of the channels centres on a tightly c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ad4521bb9c825f50f50ef400d32f31
https://kar.kent.ac.uk/66589/1/2018_Bate_Biochemistry.pdf
https://kar.kent.ac.uk/66589/1/2018_Bate_Biochemistry.pdf
Autor:
Luca G. Mureddu, Simon P. Skinner, Wayne Boucher, Geerten W. Vuister, Rasmus H. Fogh, Timothy J. Ragan
NMR spectroscopy is an indispensably powerful technique for the analysis of biomolecules under ambient conditions, both for structural- and functional studies. However, in practice the complexity of the technique has often frustrated its application
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17112a9af3ba80643ba979ecb3683253
https://europepmc.org/articles/PMC6828423/
https://europepmc.org/articles/PMC6828423/
Autor:
Jurgen F. Doreleijers, Pieter M. S. Hendrickx, Aleksandras Gutmanas, Geerten W. Vuister, Rasmus H. Fogh
Publikováno v:
Journal of Biomolecular NMR
ICT FP7 Publications Database
OpenAIRE
ICT FP7 Publications Database
OpenAIRE
Biomolecular structures at atomic resolution present a valuable resource for the understanding of biology. NMR spectroscopy accounts for 11 % of all structures in the PDB repository. In response to serious problems with the accuracy of some of the NM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c07f76651324dfa0f10502b56cd36314
https://doi.org/10.1007/s10858-013-9750-x
https://doi.org/10.1007/s10858-013-9750-x