Dissecting the Effects of Ischemia and Reperfusion on the Coronary Microcirculation in a Rat Model of Acute Myocardial Infarction.

Autor: Maurits R Hollander, Guus A de Waard, Lara S F Konijnenberg, Rosalie M E Meijer-van Putten, Charissa E van den Brom, Nanne Paauw, Helga E de Vries, Peter M van de Ven, Jurjan Aman, Geerten P Van Nieuw-Amerongen, Peter L Hordijk, Hans W M Niessen, Anton J G Horrevoets, Niels Van Royen

Publikováno v: PLoS ONE, Vol 11, Iss 7, p e0157233 (2016)

Microvascular injury (MVI) after coronary ischemia-reperfusion is associated with high morbidity and mortality. Both ischemia and reperfusion are involved in MVI, but to what degree these phases contribute is unknown. Understanding the etiology is es

Externí odkaz: https://doaj.org/article/3b01fc74cb4a4af1b885194dd9e8f53e

Transient Intervals of Hyper-Gravity Enhance Endothelial Barrier Integrity: Impact of Mechanical and Gravitational Forces Measured Electrically.

Autor: Robert Szulcek, Jan van Bezu, Johannes Boonstra, Jack J W A van Loon, Geerten P van Nieuw Amerongen

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0144269 (2015)

Endothelial cells (EC) guard vascular functions by forming a dynamic barrier throughout the vascular system that sensitively adapts to 'classical' biomechanical forces, such as fluid shear stress and hydrostatic pressure. Alterations in gravitational

Externí odkaz: https://doaj.org/article/7928f9a7b57542f6a20911acc3f06225

Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension

Autor: Ly Tu, Franziska Herrmann, Xiaoke Pan, Robert Szulcek, Frances S. de Man, Anton Vonk-Noordegraaf, Geerten P. van Nieuw Amerongen, Harm Jan Bogaard, Chris Dickhoff, Kondababu Kurakula, Christophe Guignabert, Michiel Alexander de Raaf, Denielli da Silva Goncalves Bos, Nina Rol, Vincent P Kuiper, Kirsten Lodder, Xiaoqing Q Sun, Pieter Koolwijk, Chris Happé, Ingrid Schalij, Raphaël Thuillet, Marie-José Goumans, Lutz Wollin

Publikováno v: Cardiovascular Research, 115(2), 432-439. Oxford University Press
Rol, N, de Raaf, M A, Sun, X Q, Kuiper, V P, da Silva Gonçalves Bos, D, Happé, C, Kurakula, K, Dickhoff, C, Thuillet, R, Tu, L, Guignabert, C, Schalij, I, Lodder, K, Pan, X, Herrmann, F E, van Nieuw Amerongen, G P, Koolwijk, P, Vonk-Noordegraaf, A, de Man, F S, Wollin, L, Goumans, M-J, Szulcek, R & Bogaard, H J 2019, ' Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension ', Cardiovascular Research, vol. 115, no. 2, pp. 432-439 . https://doi.org/10.1093/cvr/cvy186, https://doi.org/10.1093/cvr/cvy186
Cardiovascular Research, 115(2), 432-439. OXFORD UNIV PRESS

Aims: Pulmonary arterial hypertension (PAH) is associated with increased levels of circulating growth factors and corresponding receptors such as platelet derived growth factor, fibroblast growth factor and vascular endothelial growth factor. Ninteda

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f69fccf1fee5850e4963063aac06e1
http://www.scopus.com/inward/record.url?scp=85060365403&partnerID=8YFLogxK

Correction to: Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation

Autor: Geerten P van Nieuw Amerongen, Jurjan Aman, Kalim Nawaz, Coert Margadant, Jan van Bezu, Femke P. M. Hoevenaars, Peter L. Hordijk, Victor W.M. van Hinsbergh, Iris M. De Cuyper, Erik T. Valent, Joana Amado-Azevedo, Anne-Marieke D. van Stalborch, Etto C. Eringa

Publikováno v: Angiogenesis. 25:145-145

In the original article, due to an XML tagging error the equal contribution statement “Joana Amado-Azevedo, Anne-Marieke D. van Stalborch, Erik T. Valent have contributed equally to this work (shared first author), Jurjan Aman and Coert Margadant h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55c7f1ce80ce3eb50c24ecf2b6703e59
https://doi.org/10.1007/s10456-021-09808-3

DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis

Autor: Martijn Gloerich, Annett de Haan, Geerten P. van Nieuw Amerongen, Vivian de Waard, Jaap D. van Buul, Lilian Schimmel, Carlie J.M. de Vries, Alexandra Klaus-Bergmann, Kalim Nawaz, Anne Marieke D. Van Stalborch, Duco S. Koenis, Miesje M. van der Stoel, Stephan Huveneers, Erik T. Valent

Publikováno v: Journal of Cell Science, 133(3):jcs239947. Company of Biologists Ltd
Journal of cell science, 133(3):jcs239947. Company of Biologists Ltd
van der Stoel, M, Schimmel, L, Nawaz, K, van Stalborch, A M, de Haan, A, Klaus-Bergmann, A, Valent, E T, Koenis, D S, van Nieuw Amerongen, G P, de Vries, C J, de Waard, V, Gloerich, M, van Buul, J D & Huveneers, S 2020, ' DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis ', Journal of Cell Science, vol. 133, no. 3, jcs239947 . https://doi.org/10.1242/jcs.239947

Endothelial YAP/TAZ (YAP is also known as YAP1, and TAZ as WWTR1) signaling is crucial for sprouting angiogenesis and vascular homeostasis. However, the underlying molecular mechanisms that explain how YAP/TAZ control the vasculature remain unclear.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483de5ee0569efc7e77dc18009d06d3d
https://pubmed.ncbi.nlm.nih.gov/31964713