Zobrazeno 1 - 10 of 85 pro vyhledávání: '"Geerten P van Nieuw Amerongen"'
1
Akademický článek
A functional siRNA screen identifies RhoGTPase-associated genes involved in thrombin-induced endothelial permeability.
Autor: Joana Amado-Azevedo, Renee X de Menezes, Geerten P van Nieuw Amerongen, Victor W M van Hinsbergh, Peter L Hordijk
Publikováno v: PLoS ONE, Vol 13, Iss 7, p e0201231 (2018)
Thrombin and other inflammatory mediators may induce vascular permeability through the disruption of adherens junctions between adjacent endothelial cells. If uncontrolled, hyperpermeability leads to an impaired barrier, fluid leakage and edema, whic
Externí odkaz: https://doaj.org/article/042b282c839c4993a979d1b359e5f8cd
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3
Akademický článek
Transient Intervals of Hyper-Gravity Enhance Endothelial Barrier Integrity: Impact of Mechanical and Gravitational Forces Measured Electrically.
Autor: Robert Szulcek, Jan van Bezu, Johannes Boonstra, Jack J W A van Loon, Geerten P van Nieuw Amerongen
Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0144269 (2015)
Endothelial cells (EC) guard vascular functions by forming a dynamic barrier throughout the vascular system that sensitively adapts to 'classical' biomechanical forces, such as fluid shear stress and hydrostatic pressure. Alterations in gravitational
Externí odkaz: https://doaj.org/article/7928f9a7b57542f6a20911acc3f06225
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4
Akademický článek
Opposing effects of the angiopoietins on the thrombin-induced permeability of human pulmonary microvascular endothelial cells.
Autor: Melanie van der Heijden, Geerten P van Nieuw Amerongen, Jan van Bezu, Marinus A Paul, A B Johan Groeneveld, Victor W M van Hinsbergh
Publikováno v: PLoS ONE, Vol 6, Iss 8, p e23448 (2011)
BACKGROUND: Angiopoietin-2 (Ang-2) is associated with lung injury in ALI/ARDS. As endothelial activation by thrombin plays a role in the permeability of acute lung injury and Ang-2 may modulate the kinetics of thrombin-induced permeability by impairi
Externí odkaz: https://doaj.org/article/dd40971083d345e190b0dd99e82ce2b3
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5
Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation
Autor: Femke P. M. Hoevenaars, Geerten P van Nieuw Amerongen, Jan van Bezu, Anne-Marieke D. van Stalborch, Iris M. De Cuyper, Coert Margadant, Etto C. Eringa, Jurjan Aman, Erik T. Valent, Kalim Nawaz, Victor W.M. van Hinsbergh, Peter L. Hordijk, Joana Amado-Azevedo
Publikováno v: Angiogenesis, 24(3), 677-693. Springer Netherlands
Angiogenesis
Amado-Azevedo, J, van Stalborch, A-M D, Valent, E T, Nawaz, K, van Bezu, J, Eringa, E C, Hoevenaars, F P M, de Cuyper, I M, Hordijk, P L, van Hinsbergh, V W M, van Nieuw Amerongen, G P, Aman, J & Margadant, C 2021, ' Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation ', Angiogenesis, vol. 24, no. 3, pp. 677-693 . https://doi.org/10.1007/s10456-021-09781-x
Endothelial barrier disruption and vascular leak importantly contribute to organ dysfunction and mortality during inflammatory conditions like sepsis and acute respiratory distress syndrome. We identified the kinase Arg/Abl2 as a mediator of endothel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8958d86f669b5defa5bdce1ae8fc5fe
https://pure.amc.nl/en/publications/depletion-of-argabl2-improves-endothelial-cell-adhesion-and-prevents-vascular-leak-during-inflammation(8db11006-b7f4-4439-bcee-753401ba6b23).html
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6
Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension
Autor: Ly Tu, Franziska Herrmann, Xiaoke Pan, Robert Szulcek, Frances S. de Man, Anton Vonk-Noordegraaf, Geerten P. van Nieuw Amerongen, Harm Jan Bogaard, Chris Dickhoff, Kondababu Kurakula, Christophe Guignabert, Michiel Alexander de Raaf, Denielli da Silva Goncalves Bos, Nina Rol, Vincent P Kuiper, Kirsten Lodder, Xiaoqing Q Sun, Pieter Koolwijk, Chris Happé, Ingrid Schalij, Raphaël Thuillet, Marie-José Goumans, Lutz Wollin
Publikováno v: Cardiovascular Research, 115(2), 432-439. Oxford University Press
Rol, N, de Raaf, M A, Sun, X Q, Kuiper, V P, da Silva Gonçalves Bos, D, Happé, C, Kurakula, K, Dickhoff, C, Thuillet, R, Tu, L, Guignabert, C, Schalij, I, Lodder, K, Pan, X, Herrmann, F E, van Nieuw Amerongen, G P, Koolwijk, P, Vonk-Noordegraaf, A, de Man, F S, Wollin, L, Goumans, M-J, Szulcek, R & Bogaard, H J 2019, ' Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension ', Cardiovascular Research, vol. 115, no. 2, pp. 432-439 . https://doi.org/10.1093/cvr/cvy186, https://doi.org/10.1093/cvr/cvy186
Cardiovascular Research, 115(2), 432-439. OXFORD UNIV PRESS
Aims: Pulmonary arterial hypertension (PAH) is associated with increased levels of circulating growth factors and corresponding receptors such as platelet derived growth factor, fibroblast growth factor and vascular endothelial growth factor. Ninteda
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f69fccf1fee5850e4963063aac06e1
http://www.scopus.com/inward/record.url?scp=85060365403&partnerID=8YFLogxK
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7
Correction to: Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation
Autor: Geerten P van Nieuw Amerongen, Jurjan Aman, Kalim Nawaz, Coert Margadant, Jan van Bezu, Femke P. M. Hoevenaars, Peter L. Hordijk, Victor W.M. van Hinsbergh, Iris M. De Cuyper, Erik T. Valent, Joana Amado-Azevedo, Anne-Marieke D. van Stalborch, Etto C. Eringa
Publikováno v: Angiogenesis. 25:145-145
In the original article, due to an XML tagging error the equal contribution statement “Joana Amado-Azevedo, Anne-Marieke D. van Stalborch, Erik T. Valent have contributed equally to this work (shared first author), Jurjan Aman and Coert Margadant h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55c7f1ce80ce3eb50c24ecf2b6703e59
https://doi.org/10.1007/s10456-021-09808-3
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8
RhoA, RhoB and RhoC differentially regulate endothelial barrier function
Autor: Jan van Bezu, Victor W.M. van Hinsbergh, Geerten P. van Nieuw Amerongen, Manon C. A. Pronk, Peter L. Hordijk
Publikováno v: Small GTPases
Pronk, M C A, van Bezu, J S M, van Nieuw Amerongen, G P, van Hinsbergh, V W M & Hordijk, P L 2017, ' RhoA, RhoB and RhoC differentially regulate endothelial barrier function ', Small GTPases, pp. 1-19 . https://doi.org/10.1080/21541248.2017.1339767
Small GTPases, 10(6). Landes Bioscience
Small GTPases, 1-19. Landes Bioscience
STARTPAGE=1;ENDPAGE=19;ISSN=2154-1248;TITLE=Small GTPases
RhoGTPases are known regulators of intracellular actin dynamics that are important for maintaining endothelial barrier function. RhoA is most extensively studied as a key regulator of endothelial barrier function, however the function of the 2 highly
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70ede2f3cfc99c136558d9946acd399
http://europepmc.org/articles/PMC6748378
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9
DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis
Autor: Martijn Gloerich, Annett de Haan, Geerten P. van Nieuw Amerongen, Vivian de Waard, Jaap D. van Buul, Lilian Schimmel, Carlie J.M. de Vries, Alexandra Klaus-Bergmann, Kalim Nawaz, Anne Marieke D. Van Stalborch, Duco S. Koenis, Miesje M. van der Stoel, Stephan Huveneers, Erik T. Valent
Publikováno v: Journal of Cell Science, 133(3):jcs239947. Company of Biologists Ltd
Journal of cell science, 133(3):jcs239947. Company of Biologists Ltd
van der Stoel, M, Schimmel, L, Nawaz, K, van Stalborch, A M, de Haan, A, Klaus-Bergmann, A, Valent, E T, Koenis, D S, van Nieuw Amerongen, G P, de Vries, C J, de Waard, V, Gloerich, M, van Buul, J D & Huveneers, S 2020, ' DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis ', Journal of Cell Science, vol. 133, no. 3, jcs239947 . https://doi.org/10.1242/jcs.239947
Endothelial YAP/TAZ (YAP is also known as YAP1, and TAZ as WWTR1) signaling is crucial for sprouting angiogenesis and vascular homeostasis. However, the underlying molecular mechanisms that explain how YAP/TAZ control the vasculature remain unclear.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483de5ee0569efc7e77dc18009d06d3d
https://pubmed.ncbi.nlm.nih.gov/31964713
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10
Traction force dynamics predict gap formation in activated endothelium
Autor: Peter L. Hordijk, Victor W.M. van Hinsbergh, Erik T. Valent, Geerten P. van Nieuw Amerongen
Publikováno v: Valent, E T, van Nieuw Amerongen, G, van Hinsbergh, V W M & Hordijk, P L 2016, ' Traction force dynamics predict gap formation in activated endothelium ', Experimental Cell Research, vol. 347, no. 1, pp. 161-170 . https://doi.org/10.1016/j.yexcr.2016.07.029
Experimental Cell Research, 347(1), 161-170. Academic Press Inc.
In many pathological conditions the endothelium becomes activated and dysfunctional, resulting in hyperpermeability and plasma leakage. No specific therapies are available yet to control endothelial barrier function, which is regulated by inter-endot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9d409a1ea320699c88882c9f9c3084
https://doi.org/10.1016/j.yexcr.2016.07.029
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