Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Geert-Jan van Gemert"'
Autor:
Maartje R. Inklaar, Roos M. de Jong, Ezra T. Bekkering, Hikaru Nagaoka, Felix L. Fennemann, Karina Teelen, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Rianne Stoter, C. Richter King, Nicholas I. Proellochs, Teun Bousema, Eizo Takashima, Takafumi Tsuboi, Matthijs M. Jore
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-8 (2023)
Abstract Malaria transmission-blocking vaccines (TBVs) aim to induce antibodies that block Plasmodium parasite development in the mosquito midgut, thus preventing mosquitoes from becoming infectious. While the Pro-domain and first of fourteen 6-Cyste
Externí odkaz:
https://doaj.org/article/873417ee2eae4bd1826b51bf24506c7a
Autor:
Chiara Andolina, Wouter Graumans, Moussa Guelbeogo, Geert-Jan van Gemert, Jordache Ramijth, Soré Harouna, Zongo Soumanaba, Rianne Stoter, Marga Vegte-Bolmer, Martina Pangos, Photini Sinnis, Katharine Collins, Sarah G Staedke, Alfred B Tiono, Chris Drakeley, Kjerstin Lanke, Teun Bousema
Publikováno v:
eLife, Vol 12 (2024)
It is currently unknown whether all Plasmodium falciparum-infected mosquitoes are equally infectious. We assessed sporogonic development using cultured gametocytes in the Netherlands and naturally circulating strains in Burkina Faso. We quantified th
Externí odkaz:
https://doaj.org/article/be98e34cc5dd4122ad803aa3d9086ded
Autor:
Annie S. P. Yang, Devanjali Dutta, Kai Kretzschmar, Delilah Hendriks, Jens Puschhof, Huili Hu, Kim E. Boonekamp, Youri van Waardenburg, Susana M. Chuva de Sousa Lopes, Geert-Jan van Gemert, Johannes H. W. de Wilt, Teun Bousema, Hans Clevers, Robert W. Sauerwein
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Plasmodium falciparum (Pf) parasite development in liver represents the initial step of the life-cycle in the human host after a Pf-infected mosquito bite. While an attractive stage for life-cycle interruption, understanding of parasite-hepa
Externí odkaz:
https://doaj.org/article/5c88670c6cde4830afc419a55a86cad4
Autor:
Saskia C. van der Boor, Manon Alkema, Geert-Jan van Gemert, Karina Teelen, Marga van de Vegte-Bolmer, Jona Walk, Reinout van Crevel, Quirijn de Mast, Christian F. Ockenhouse, Robert W. Sauerwein, Matthew B. B. McCall
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Background Whole sporozoite immunization under chemoprophylaxis (CPS regime) induces long-lasting sterile homologous protection in the controlled human malaria infection model using Plasmodium falciparum strain NF54. The relative proficiency
Externí odkaz:
https://doaj.org/article/28495ce92cd3443cb2435728df4cd2f2
Autor:
Damian Madan, Rafael Rivera, Corrie Ortega, Justin C. Touchon, Corinna Kimball, Geert-Jan van Gemert, Wouter Graumans, Stephanie Matsuura, Sean S. Parghi, David Bell, Teun Bousema, Chris Drakeley, Katharine A. Collins, Thomas R. Burkot
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Vector control strategies are among the most effective measures to combat mosquito-borne diseases, such as malaria. These strategies work by altering the mosquito age structure through increased mortality of the older female mosquitoes that
Externí odkaz:
https://doaj.org/article/f3a1d535e62e428e8e03851a5bd51e40
Autor:
Susheel K. Singh, Jordan Plieskatt, Bishwanath K. Chourasia, Vandana Singh, Karin Lövgren Bengtsson, Jenny M. Reimer, Renate C. van Daalen, Karina Teelen, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Matthijs M. Jore, Michael Theisen
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)
Abstract The Plasmodium falciparum Pfs230 and Pfs48/45 proteins are leading candidates for a malaria transmission-blocking vaccine (TBV). Previously, we showed that a Pfs230–Pfs48/45 fusion protein elicits higher levels of functional antibodies tha
Externí odkaz:
https://doaj.org/article/d23619f475cb4d5dbe3391e5cc32c116
Autor:
Marga van de Vegte-Bolmer, Wouter Graumans, Rianne Stoter, Geert-Jan van Gemert, Robert Sauerwein, Katharine A. Collins, Teun Bousema
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-10 (2021)
Abstract Background The ability to culture Plasmodium falciparum continuously in vitro has enabled stable access to asexual and sexual parasites for malaria research. The portfolio of isolates has remained limited and research is still largely based
Externí odkaz:
https://doaj.org/article/74833f3d5a7348b299bf409cd6b49e04
Autor:
Ayman Khattab, Mikel Rezola, Marta Barroso, Mikael Kyrklund, Tero Pihlajamaa, Tobias L. Freitag, Geert-Jan van Gemert, Teun Bousema, Perttu Permi, Ossi Turunen, Robert Sauerwein, Adrian J. F. Luty, Seppo Meri
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The complement system is considered the first line of defense against pathogens. Hijacking complement regulators from blood is a common evasion tactic of pathogens to inhibit complement activation on their surfaces. Here, we report hijacking of the c
Externí odkaz:
https://doaj.org/article/f2b7bff8992c46d0b53b8fb320cfed0c
Autor:
Roos M. de Jong, Lisette Meerstein-Kessel, Dari F. Da, Sandrine Nsango, Joseph D. Challenger, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Elias Duarte, Noam Teyssier, Robert W. Sauerwein, Thomas S. Churcher, Roch K. Dabire, Isabelle Morlais, Emily Locke, Martijn A. Huynen, Teun Bousema, Matthijs M. Jore
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract Malaria parasite transmission to mosquitoes relies on the uptake of sexual stage parasites during a blood meal and subsequent formation of oocysts on the mosquito midgut wall. Transmission-blocking vaccines (TBVs) and monoclonal antibodies (
Externí odkaz:
https://doaj.org/article/852c3163e8664f10865e9f61f43db532
Autor:
Sylwia D. Boltryk, Armin Passecker, Arne Alder, Eilidh Carrington, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Alex van der Starre, Hans-Peter Beck, Robert W. Sauerwein, Taco W. A. Kooij, Nicolas M. B. Brancucci, Nicholas I. Proellochs, Tim-Wolf Gilberger, Till S. Voss
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
During each replication cycle of P. falciparum in the human bloodstream, a small proportion of parasites commits to sexual development and differentiates into transmission-relevant gametocytes. Applying CRISPR-based genome editing, Boltryk et al. eng
Externí odkaz:
https://doaj.org/article/bdde91798fe34a80b40c88b2bfa92cdd