Výsledky vyhledávání - "Geert de Vreede"

Akademický článek

PTP10D-mediated cell competition is not obligately required for elimination of polarity-deficient clones

Autor: Stephan U. Gerlach, Geert de Vreede, David Bilder

Publikováno v: Biology Open, Vol 11, Iss 11 (2022)

Externí odkaz: https://doaj.org/article/69194fabe8c24a218f29b4d6ecb5d44f

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Epithelial monitoring via ligand-receptor segregation ensures malignant cell elimination

Autor: Geert de Vreede, Stephan U. Gerlach, David Bilder

Publikováno v: Science

Animals have evolved mechanisms, such as cell competition, to remove dangerous or nonfunctional cells from a tissue. Tumor necrosis factor signaling can eliminate clonal malignancies from Drosophila imaginal epithelia, but why this pathway is activat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af0bbb30b047f8d9d8fbb18a3c4543a
https://europepmc.org/articles/PMC9197687/

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A Drosophila Tumor Suppressor Gene Prevents Tonic TNF Signaling through Receptor N-Glycosylation

Autor: Ryan M. Boileau, Julien Colombani, Alexandra M. Houser, Ditte S. Andersen, Holly A. Morrison, David Bilder, Geert de Vreede

Publikováno v: Developmental cell, vol 45, iss 5

Drosophila tumor suppressor genes have revealed molecular pathways that control tissue growth, but mechanisms that regulate mitogenic signaling are far from understood. Here we report that the Drosophila TSG tumorous imaginal discs (tid), whose pheno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62433f080cd65c15e27d6702f2df362
https://pubmed.ncbi.nlm.nih.gov/29870719

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The F-box protein Slmb restricts the activity of aPKC to polarize epithelial cells

Autor: David Bilder, Geert de Vreede, Gregory C. Rogers, Lara C. Skwarek, Sarah L. Windler

Publikováno v: Skwarek, LC; Windler, SL; de Vreede, G; Rogers, GC; & Bilder, D. (2014). The F-box protein Slmb restricts the activity of aPKC to polarize epithelial cells. Development (Cambridge), 141(15), 2978-2983. doi: 10.1242/dev.109694. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/4hr9g7hj

The Par-3/Par-6/aPKC complex is the primary determinant of apical polarity in epithelia across animal species, but how the activity of this complex is restricted to allow polarization of the basolateral domain is less well understood. In Drosophila,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e64124ccf512b27c419a81db8c33ebf3
https://europepmc.org/articles/PMC4197664/

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