Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Geert Van Loo"'
Autor:
Hannah Stocks, Elisabeth De Leeuw, Bart N. Lambrecht, Linos Vandekerckhove, Geert van Loo, Andy Wullaert
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundDysregulated innate immune responses underlie multiple inflammatory diseases, but clinical translation of preclinical innate immunity research in mice is hampered by the difficulty of studying human inflammatory reactions in an in vivo cont
Externí odkaz:
https://doaj.org/article/cc23fd94c5e84069976b292763983fed
Autor:
Ine Paesmans, Kristof Van Kolen, Marc Vandermeeren, Pei-Yu Shih, Dirk Wuyts, Fleur Boone, Sergio Garcia Sanchez, Karolien Grauwen, Filip Van Hauwermeiren, Nina Van Opdenbosch, Mohamed Lamkanfi, Geert van Loo, Astrid Bottelbergs
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
BackgroundNeuroinflammation is widely recognized as a key factor in the pathogenesis of Alzheimer’s disease (AD), alongside ß-amyloid deposition and the formation of neurofibrillary tangles. The NLR family pyrin domain containing 3 (NLRP3) inflamm
Externí odkaz:
https://doaj.org/article/ce931bbf061143caa3b0692f21880bfb
Autor:
Ioanna Petta, Marie Thorp, Maarten Ciers, Gillian Blancke, Louis Boon, Tim Meese, Filip Van Nieuwerburgh, Andy Wullaert, Richard Grencis, Dirk Elewaut, Geert van Loo, Lars Vereecke
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundProtective immunity against intestinal helminths requires induction of robust type-2 immunity orchestrated by various cellular and soluble effectors which promote goblet cell hyperplasia, mucus production, epithelial proliferation, and smoo
Externí odkaz:
https://doaj.org/article/4430a9dec9a04b37b1e9e9b55eb09f9c
Autor:
Karel F. A. Van Damme, Pieter Hertens, Arne Martens, Elisabeth Gilis, Dario Priem, Inge Bruggeman, Amelie Fossoul, Jozefien Declercq, Helena Aegerter, Andy Wullaert, Tino Hochepied, Esther Hoste, Lieselotte Vande Walle, Mohamed Lamkanfi, Savvas N. Savvides, Dirk Elewaut, Bart N. Lambrecht, Geert van Loo
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract A20 serves as a critical brake on NF-κB-dependent inflammation. In humans, polymorphisms in or near the TNFAIP3/A20 gene have been linked to various inflammatory disorders, including systemic lupus erythematosus (SLE) and rheumatoid arthrit
Externí odkaz:
https://doaj.org/article/0bf2e4c99bae45e2afbc4924a4035aa2
Autor:
Lien Verboom, Christopher J. Anderson, Maude Jans, Ioanna Petta, Gillian Blancke, Arne Martens, Mozes Sze, Tino Hochepied, Kodi S. Ravichandran, Lars Vereecke, Geert van Loo
Publikováno v:
Cell Death and Disease, Vol 14, Iss 8, Pp 1-13 (2023)
Abstract The intestinal epithelium is a single cell layer that is constantly renewed and acts as a physical barrier that separates intestinal microbiota from underlying tissues. In inflammatory bowel disease (IBD) in humans, as well as in experimenta
Externí odkaz:
https://doaj.org/article/7eadb0df90114b9c9cc7180ab08eeb46
Autor:
Sahana Srinivasan, Daliya Kancheva, Sofie De Ren, Takashi Saito, Maude Jans, Fleur Boone, Charysse Vandendriessche, Ine Paesmans, Hervé Maurin, Roosmarijn E. Vandenbroucke, Esther Hoste, Sofie Voet, Isabelle Scheyltjens, Benjamin Pavie, Saskia Lippens, Marius Schwabenland, Marco Prinz, Takaomi Saido, Astrid Bottelbergs, Kiavash Movahedi, Mohamed Lamkanfi, Geert van Loo
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundAlzheimer’s disease (AD) is the most common neurodegenerative disorder affecting memory and cognition. The disease is accompanied by an abnormal deposition of ß-amyloid plaques in the brain that contributes to neurodegeneration and is kn
Externí odkaz:
https://doaj.org/article/9176fde1a9644a96960b77fefeca6640
Autor:
Elien Eeckhout, Lisa Hamerlinck, Veronique Jonckheere, Petra Van Damme, Geert van Loo, Andy Wullaert
Publikováno v:
Cell Death and Disease, Vol 14, Iss 4, Pp 1-16 (2023)
Abstract Citrobacter rodentium is an enteropathogen that causes intestinal inflammatory responses in mice reminiscent of the pathology provoked by enteropathogenic and enterohemorrhagic Escherichia coli infections in humans. C. rodentium expresses va
Externí odkaz:
https://doaj.org/article/5979f518de434555b00d37dbbe8ecd50
Autor:
Elien Eeckhout, Tomoko Asaoka, Hanne Van Gorp, Dieter Demon, Charlotte Girard-Guyonvarc’h, Vanessa Andries, Lars Vereecke, Cem Gabay, Mohamed Lamkanfi, Geert van Loo, Andy Wullaert
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundAutoinflammation with infantile enterocolitis (AIFEC) is an often fatal disease caused by gain-of-function mutations in the NLRC4 inflammasome. This inflammasomopathy is characterized by macrophage activation syndrome (MAS)-like episodes as
Externí odkaz:
https://doaj.org/article/22257ef24119463f84ae7fbc3bf11db2
Autor:
Peng Xiao, Tatiana Takiishi, Natalia Moretti Violato, Giada Licata, Francesco Dotta, Guido Sebastiani, Lorella Marselli, Sumeet Pal Singh, Mozes Sze, Geert Van Loo, Emmanuel Dejardin, Esteban Nicolas Gurzov, Alessandra Kupper Cardozo
Publikováno v:
Cell Death and Disease, Vol 13, Iss 5, Pp 1-11 (2022)
Abstract The transcription factor nuclear factor-κB (NF-κB) has a key role in the pathogenesis of diabetes and its complications. Although activation of the canonical NF-κB pathway in β-cells is generally deleterious, little is known about the ro
Externí odkaz:
https://doaj.org/article/1277c1357f0c4eb8aed8ef4ecac0ad73
Autor:
Esther Hoste, Kim Lecomte, Karl Annusver, Niels Vandamme, Jana Roels, Sophia Maschalidi, Lien Verboom, Hanna-Kaisa Vikkula, Mozes Sze, Lisette Van Hove, Kevin Verstaen, Arne Martens, Tino Hochepied, Yvan Saeys, Kodi Ravichandran, Maria Kasper, Geert van Loo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
OTULIN is a deubiquitinase for linear ubiquitin chains. Here the authors show, using genetic mouse models and single-cell RNA-sequencing, that deficiency of OTULIN in keratinocytes causes skin inflammation and verrucous carcinoma via the induction of
Externí odkaz:
https://doaj.org/article/8b051a56d99b49d783afe85a0b01f20a