Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Geert Stangé"'
Autor:
Geert A. Martens, Geert Stangé, Lorenzo Piemonti, Jasper Anckaert, Zhidong Ling, Daniel G. Pipeleers, Frans K. Gorus, Pieter Mestdagh, Dieter De Smet, Jo Vandesompele, Bart Keymeulen, Sarah Roels
Publikováno v:
Cells, Vol 10, Iss 7, p 1693 (2021)
Ongoing beta cell death in type 1 diabetes (T1D) can be detected using biomarkers selectively discharged by dying beta cells into plasma. microRNA-375 (miR-375) ranks among the top biomarkers based on studies in animal models and human islet transpla
Externí odkaz:
https://doaj.org/article/0140f1c493544f638afd98132e0142d6
Autor:
Sarah Akbib, Jordy Stichelmans, Geert Stangé, Zhidong Ling, Zerihun Assefa, Karine H Hellemans
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212210 (2019)
Cell therapy for diabetes could benefit from the identification of small-molecule compounds that increase the number of functional pancreatic beta cells. Using a newly developed screening assay, we previously identified glucocorticoids as potent stim
Externí odkaz:
https://doaj.org/article/9acf06ab78274133ac0d6a6f408bc9b0
Autor:
Olivier R Costa, Katrijn Verhaeghen, Sarah Roels, Geert Stangé, Zhidong Ling, Daniel Pipeleers, Frans K Gorus, Geert A Martens
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193670 (2018)
A disproportional increase of circulating GAD65 within hours from an intraportal islet allotransplantation has been validated as biomarker of beta cell loss and poor functional outcome. More sensitive assays are, however, needed to allow detection of
Externí odkaz:
https://doaj.org/article/1c9880289ca64b3687bec2194a81b476
Autor:
Zerihun Assefa, Astrid Lavens, Christophe Steyaert, Geert Stangé, Geert A Martens, Zhidong Ling, Karine Hellemans, Daniel Pipeleers
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85174 (2014)
BACKGROUND: Glucose effects on beta cell survival and DNA-synthesis suggest a role as regulator of beta cell mass but data on beta cell numbers are lacking. We examined outcome of these influences on the number of beta cells isolated at different gro
Externí odkaz:
https://doaj.org/article/c4c3802e097c41ca94d2fe931e66f3f3
Autor:
Lei Ding, Conny A Gysemans, Geert Stangé, Yves Heremans, Yixing Yuchi, Tatiana Takiishi, Hannelie Korf, Marie Chintinne, Richard D Carr, Harry Heimberg, Daniel Pipeleers, Chantal Mathieu
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107935 (2014)
Combining immune intervention with therapies that directly influence the functional state of the β-cells is an interesting strategy in type 1 diabetes cure. Dipeptidyl peptidase-4 (DPP-4) inhibitors elevate circulating levels of active incretins, wh
Externí odkaz:
https://doaj.org/article/84df19f0b37e4cebb87a8ce89da6b98d
Autor:
Geert A. Martens, Lei Jiang, Karine H. Hellemans, Geert Stangé, Harry Heimberg, Finn C. Nielsen, Olivier Sand, Jacques Van Helden, Leentje Van Lommel, Frans Schuit, Frans K. Gorus, Daniel G. Pipeleers
Publikováno v:
PLoS ONE, Vol 7, Iss 1 (2012)
Externí odkaz:
https://doaj.org/article/077e6b4b1b4e4aa688c8ec58d73f99c4
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43959 (2012)
BACKGROUND: Pancreatic-tail duct ligation (PDL) in adult rodents has been reported to induce beta cell generation and increase beta cell mass but increases in beta cell number have not been demonstrated. This study examines whether PDL increases beta
Externí odkaz:
https://doaj.org/article/f427adb9f7f546ee995e3ce9e5fd949a
Autor:
Geert A Martens, Lei Jiang, Karine H Hellemans, Geert Stangé, Harry Heimberg, Finn C Nielsen, Olivier Sand, Jacques Van Helden, Leentje Van Lommel, Frans Schuit, Frans K Gorus, Daniel G Pipeleers
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24134 (2011)
BACKGROUND AND METHODOLOGY: The aim of this study was to establish a gene expression blueprint of pancreatic beta cells conserved from rodents to humans and to evaluate its applicability to assess shifts in the beta cell differentiated state. Genome-
Externí odkaz:
https://doaj.org/article/3f92a588ceaa4e308a290e027fb10a8b
Autor:
Geert A Martens, Lei Jiang, Katrijn Verhaeghen, Joanne B Connolly, Scott G Geromanos, Geert Stangé, Laurence Van Oudenhove, Bart Devreese, Karine H Hellemans, Zhidong Ling, Christiaan Van Schravendijk, Daniel G Pipeleers, Johannes P C Vissers, Frans K Gorus
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14214 (2010)
BACKGROUND AND METHODOLOGY: Pancreatic beta cells show intercellular differences in their metabolic glucose sensitivity and associated activation of insulin production. To identify protein markers for these variations in functional glucose sensitivit
Externí odkaz:
https://doaj.org/article/ff70921e2dad4767b50291c97c665b97
Autor:
Jo A. Van Ginderachter, Patrick De Baetselier, Peter In't Veld, Daniel Pipeleers, Matthias Mack, Jan Van den Bossche, Geert Stangé, Martijn Baeten, Conny Gysemans, Damya Laoui, Kiavash Movahedi
Supplementary Materials, Tables 1-4, Figures 1-10 from Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e592993f6b5da56d488beac3ff40a4b7
https://doi.org/10.1158/0008-5472.22383945.v1
https://doi.org/10.1158/0008-5472.22383945.v1