Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Geert Raes"'
Autor:
Robin Maximilian Awad, Yannick De Vlaeminck, Fien Meeus, Thomas Ertveldt, Katty Zeven, Hannelore Ceuppens, Cleo Goyvaerts, Magali Verdonck, Gustavo Salguero, Geert Raes, Nick Devoogdt, Karine Breckpot
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Blockade of the immune checkpoint axis consisting of programmed death-1 (PD-1) and its ligand PD-L1 alleviates the functional inhibition of tumor-infiltrating lymphoid cells yet weakly induces their expansion. Exogenous cytokines could furth
Externí odkaz:
https://doaj.org/article/9fb28e6fbf3b4facb292f00890c954cc
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/54bcbcb7c0884214a12fdbf6ac67f6c2
Autor:
Katty Zeven, Timo W.M. De Groof, Hannelore Ceuppens, Robin Maximilian Awad, Thomas Ertveldt, Wout de Mey, Fien Meeus, Geert Raes, Karine Breckpot, Nick Devoogdt
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionT cell Ig and ITIM domain receptor (TIGIT) is a next-generation immune checkpoint predominantly expressed on activated T cells and NK cells, exhibiting an unfavorable prognostic association with various malignancies. Despite the emergence
Externí odkaz:
https://doaj.org/article/051a7b27d7524e158560ba763978542a
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Nanobodies are antibody fragments derived from camelids, naturally endowed with properties like low molecular weight, high affinity and low immunogenicity, which contribute to their effective use as research tools, but also as diagnostic and therapeu
Externí odkaz:
https://doaj.org/article/5f57c23e2a5143aca619a80073331bf9
Autor:
Robin Maximilian Awad, Quentin Lecocq, Katty Zeven, Thomas Ertveldt, Lien De Beck, Hannelore Ceuppens, Katrijn Broos, Yannick De Vlaeminck, Cleo Goyvaerts, Magali Verdonck, Geert Raes, Alexander Van Parys, Anje Cauwels, Marleen Keyaerts, Nick Devoogdt, Karine Breckpot
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 172-182 (2021)
Monoclonal antibodies that target the inhibitory immune checkpoint axis consisting of programmed cell death protein 1 (PD-1) and its ligand, PD-L1, have changed the immune-oncology field. We identified K2, an anti-human PD-L1 single-domain antibody f
Externí odkaz:
https://doaj.org/article/a02773e0d7c64fbda016a0f01cb0fe31
Autor:
Zohreh Varasteh, Miriam Braeuer, Sarajo Mohanta, Anna-Lena Steinsiek, Andreas Habenicht, Negar Omidvari, Geoffrey J. Topping, Christoph Rischpler, Wolfgang A. Weber, Hendrik B. Sager, Geert Raes, Sophie Hernot, Markus Schwaiger
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Introduction and ObjectivesWound healing after myocardial infarction (MI) is a dynamic and complex multiple phase process, and a coordinated cellular response is required for proper scar formation. The current paradigm suggests that pro-inflammatory
Externí odkaz:
https://doaj.org/article/d98225bbd7ee46938dfd124252dd82bd
Autor:
Karen De Vlaminck, Ema Romão, Janik Puttemans, Ana Rita Pombo Antunes, Daliya Kancheva, Isabelle Scheyltjens, Jo A. Van Ginderachter, Serge Muyldermans, Nick Devoogdt, Kiavash Movahedi, Geert Raes
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Glioblastoma (GBM) is the most common malignant primary brain tumor. Glioblastomas contain a large non-cancerous stromal compartment including various populations of tumor-associated macrophages and other myeloid cells, of which the presence was docu
Externí odkaz:
https://doaj.org/article/22816153b4a84f9e978050703b2fef79
Autor:
Zohreh Varasteh, Sarajo Mohanta, Yuanfang Li, Nicolás López Armbruster, Miriam Braeuer, Stephan G. Nekolla, Andreas Habenicht, Hendrik B. Sager, Geert Raes, Wolfgang Weber, Sophie Hernot, Markus Schwaiger
Publikováno v:
EJNMMI Research, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract Background Rupture-prone atherosclerotic plaques are characterized by heavy macrophage infiltration, and the presence of certain macrophage subsets might be a sign for plaque vulnerability. The mannose receptor (MR, CD206) is over-expressed
Externí odkaz:
https://doaj.org/article/a6e02592a36643b49568dc4b627a95cd
Autor:
Fang Zheng, Jinhong Zhou, Zhenlin Ouyang, Jiaxin Zhang, Xinyi Wang, Serge Muyldermans, Jo Van Ginderachter, Nick Devoogdt, Yurong Wen, Steve Schoonooghe, Geert Raes
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Nanobodies that are derived from single-chain antibodies of camelids have served as powerful tools in diagnostics, therapeutics and investigation of membrane receptors' structure and function. In this study, we developed a series of nanobodies by a p
Externí odkaz:
https://doaj.org/article/26d23f5c298d4bee9151890c8653099c
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Monocytes influence multiple aspects of tumor progression, including antitumor immunity, angiogenesis, and metastasis, primarily by infiltrating tumors, and differentiating into tumor-associated macrophages. Emerging evidence suggests that the tumor-
Externí odkaz:
https://doaj.org/article/2b589f6467254f9b9b14d1bd9a4e5b56