Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Geert J. P. L. Kops"'
Autor:
Kristiaan J. Lenos, Sander Bach, Leandro Ferreira Moreno, Sanne ten Hoorn, Nina R. Sluiter, Sanne Bootsma, Felipe A. Vieira Braga, Lisanne E. Nijman, Tom van den Bosch, Daniel M. Miedema, Erik van Dijk, Bauke Ylstra, Ruth Kulicke, Fred P. Davis, Nicolas Stransky, Gromoslaw A. Smolen, Robert R. J. Coebergh van den Braak, Jan N. M. IJzermans, John W. M. Martens, Sally Hallam, Andrew D. Beggs, Geert J. P. L. Kops, Nico Lansu, Vivian P. Bastiaenen, Charlotte E. L. Klaver, Maria C. Lecca, Khalid El Makrini, Clara C. Elbers, Mark P. G. Dings, Carel J. M. van Noesel, Onno Kranenburg, Jan Paul Medema, Jan Koster, Lianne Koens, Cornelis J. A. Punt, Pieter J. Tanis, Ignace H. de Hingh, Maarten F. Bijlsma, Jurriaan B. Tuynman, Louis Vermeulen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Colorectal cancer can lead to the development of peritoneal metastases, which are associated with worse disease outcome. Here, the authors characterize peritoneal metastases from 52 patients using RNA-seq and mutational sequencing and show a distinct
Externí odkaz:
https://doaj.org/article/369abe186b03465f8bac79e90a4d4606
Autor:
Dayana E. Salas-Leiva, Eelco C. Tromer, Bruce A. Curtis, Jon Jerlström-Hultqvist, Martin Kolisko, Zhenzhen Yi, Joan S. Salas-Leiva, Lucie Gallot-Lavallée, Shelby K. Williams, Geert J. P. L. Kops, John M. Archibald, Alastair G. B. Simpson, Andrew J. Roger
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
Externí odkaz:
https://doaj.org/article/4f649da9574b44878fcbb40345fe2a83
Autor:
Dayana E. Salas-Leiva, Eelco C. Tromer, Bruce A. Curtis, Jon Jerlström-Hultqvist, Martin Kolisko, Zhenzhen Yi, Joan S. Salas-Leiva, Lucie Gallot-Lavallée, Shelby K. Williams, Geert J. P. L. Kops, John M. Archibald, Alastair G. B. Simpson, Andrew J. Roger
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The mechanisms for replicating and segregating DNA are highly conserved across eukaryotes. A comparative genomic analysis of a free-living protist finds a surprising lack of protein complexes involved in these processes, suggesting that the organism
Externí odkaz:
https://doaj.org/article/53b88dba845e440e95e7fa4a170fb0c8
Autor:
Erik van Dijk, Tom van den Bosch, Kristiaan J. Lenos, Khalid El Makrini, Lisanne E. Nijman, Hendrik F. B. van Essen, Nico Lansu, Michiel Boekhout, Joris H. Hageman, Rebecca C. Fitzgerald, Cornelis J. A. Punt, Jurriaan B. Tuynman, Hugo J. G. Snippert, Geert J. P. L. Kops, Jan Paul Medema, Bauke Ylstra, Louis Vermeulen, Daniël M. Miedema
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Intratumour heterogeneity (ITH) is associated with worse prognosis in cancer, and efficient frameworks to measure it are needed. Here the authors develop a method to estimate copy number heterogeneity, and propose that it is driven by chromosomal ins
Externí odkaz:
https://doaj.org/article/264d1331d97845559b189b69b84d9dcb
Autor:
Sjoerd J. Klaasen, Geert J. P. L. Kops
Publikováno v:
Cells, Vol 11, Iss 22, p 3564 (2022)
Aneuploidy is a hallmark of cancer and a major cause of miscarriages in humans. It is caused by chromosome segregation errors during cell divisions. Evidence is mounting that the probability of specific chromosomes undergoing a segregation error is n
Externí odkaz:
https://doaj.org/article/1d4cce1dc02349f3950f685659fd19bb
Autor:
Wilma H. M. Hoevenaar, Aniek Janssen, Ajit I. Quirindongo, Huiying Ma, Sjoerd J. Klaasen, Antoinette Teixeira, Bastiaan van Gerwen, Nico Lansu, Folkert H. M. Morsink, G. Johan A. Offerhaus, René H. Medema, Geert J. P. L. Kops, Nannette Jelluma
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Aneuploidy caused by chromosomal instability is frequently observed in cancer, but little is known about its contribution to tumor development. Here, the authors show that in the mouse intestine, the consequences of aneuploidy are exquisitely depende
Externí odkaz:
https://doaj.org/article/118f25f0a18f4b6ea689450fb6a3c626
Autor:
Marilena Rizzo, Tom A. E. Stout, Santo Cristarella, Marco Quartuccio, Geert J. P. L. Kops, Marta De Ruijter-Villani
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Aneuploidy originating during meiosis in oocytes is the major cause of reduced fertility, implantation failure and miscarriage in women beyond their mid-thirties. Loss of chromosome cohesion, and defective microtubule dynamics and spindle assembly ar
Externí odkaz:
https://doaj.org/article/f5ed265772a84bdf80fa048d16c4327c
Autor:
Pilar Mur, Richarda M. De Voer, Rubén Olivera-Salguero, Sandra Rodríguez-Perales, Tirso Pons, Fernando Setién, Gemma Aiza, Rafael Valdés-Mas, Angelo Bertini, Marta Pineda, Lilian Vreede, Matilde Navarro, Silvia Iglesias, Sara González, Joan Brunet, Alfonso Valencia, Manel Esteller, Conxi Lázaro, Geert J. P. L. Kops, Miguel Urioste, Xose S. Puente, Gabriel Capellá, Laura Valle
Publikováno v:
Molecular Cancer, Vol 17, Iss 1, Pp 1-6 (2018)
Abstract Germline mutations in BUB1 and BUB3 have been reported to increase the risk of developing colorectal cancer (CRC) at young age, in presence of variegated aneuploidy and reminiscent dysmorphic traits of mosaic variegated aneuploidy syndrome.
Externí odkaz:
https://doaj.org/article/ac7a108e73bd4dcd8e288ed0828cb856
Publikováno v:
Open Biology, Vol 8, Iss 8 (2018)
Discovered in 1991 in a screen for genes involved in spindle pole body duplication, the monopolar spindle 1 (Mps1) kinase has since claimed a central role in processes that ensure error-free chromosome segregation. As a result, Mps1 kinase activity h
Externí odkaz:
https://doaj.org/article/48cdcd54d5d04a6d995b85c72a58f1a6
Autor:
Jiao Wang, Zhizhi Wang, Tingting Yu, Huan Yang, David M. Virshup, Geert J. P. L. Kops, Sang Hyun Lee, Weihong Zhou, Xin Li, Wenqing Xu, Zihe Rao
Publikováno v:
Protein & Cell, Vol 7, Iss 7, Pp 516-526 (2016)
ABSTRACT Protein phosphatase 2A (PP2A) accounts for the majority of total Ser/Thr phosphatase activities in most cell types and regulates many biological processes. PP2A holoenzymes contain a scaffold A subunit, a catalytic C subunit, and one of the
Externí odkaz:
https://doaj.org/article/7c583d599c59406bb37f7f04074eeff5