Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Geert J P L Kops"'
Autor:
Katharina Overlack, Ivana Primorac, Mathijs Vleugel, Veronica Krenn, Stefano Maffini, Ingrid Hoffmann, Geert J P L Kops, Andrea Musacchio
Publikováno v:
eLife, Vol 4 (2015)
The spindle assembly checkpoint (SAC) monitors and promotes kinetochore–microtubule attachment during mitosis. Bub1 and BubR1, SAC components, originated from duplication of an ancestor gene. Subsequent sub-functionalization established subordinati
Externí odkaz:
https://doaj.org/article/d58b367dc64a442eaf360a3ccefc8014
Autor:
Loes A L van de Pasch, Antony J Miles, Wilco Nijenhuis, Nathalie A C H Brabers, Dik van Leenen, Philip Lijnzaad, Markus K Brown, Jimmy Ouellet, Yves Barral, Geert J P L Kops, Frank C P Holstege
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65628 (2013)
The Saccharomyces cerevisiae Slx5/8 complex is the founding member of a recently defined class of SUMO-targeted ubiquitin ligases (STUbLs). Slx5/8 has been implicated in genome stability and transcription, but the precise contribution is unclear. To
Externí odkaz:
https://doaj.org/article/adb16228f63c4339ad1d4a5aec022f62
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10251 (2010)
Proper execution of chromosome segregation relies on tight control of attachment of chromosomes to spindle microtubules. This is monitored by the mitotic checkpoint that allows chromosome segregation only when all chromosomes are stably attached. Pro
Externí odkaz:
https://doaj.org/article/78a11d72bfe84dcdb36e1440f4408ebe
Autor:
Nannette Jelluma, Arjan B Brenkman, Ian McLeod, John R Yates, Don W Cleveland, René H Medema, Geert J P L Kops
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2415 (2008)
BACKGROUND: Chromosomal instability (CIN), a feature widely shared by cells from solid tumors, is caused by occasional chromosome missegregations during cell division. Two of the causes of CIN are weakened mitotic checkpoint signaling and persistent
Externí odkaz:
https://doaj.org/article/a85dd1c2764b4994aa7b4c8740159ff4
Autor:
Kristiaan J. Lenos, Sander Bach, Leandro Ferreira Moreno, Sanne ten Hoorn, Nina R. Sluiter, Sanne Bootsma, Felipe A. Vieira Braga, Lisanne E. Nijman, Tom van den Bosch, Daniel M. Miedema, Erik van Dijk, Bauke Ylstra, Ruth Kulicke, Fred P. Davis, Nicolas Stransky, Gromoslaw A. Smolen, Robert R. J. Coebergh van den Braak, Jan N. M. IJzermans, John W. M. Martens, Sally Hallam, Andrew D. Beggs, Geert J. P. L. Kops, Nico Lansu, Vivian P. Bastiaenen, Charlotte E. L. Klaver, Maria C. Lecca, Khalid El Makrini, Clara C. Elbers, Mark P. G. Dings, Carel J. M. van Noesel, Onno Kranenburg, Jan Paul Medema, Jan Koster, Lianne Koens, Cornelis J. A. Punt, Pieter J. Tanis, Ignace H. de Hingh, Maarten F. Bijlsma, Jurriaan B. Tuynman, Louis Vermeulen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Colorectal cancer can lead to the development of peritoneal metastases, which are associated with worse disease outcome. Here, the authors characterize peritoneal metastases from 52 patients using RNA-seq and mutational sequencing and show a distinct
Externí odkaz:
https://doaj.org/article/369abe186b03465f8bac79e90a4d4606
Autor:
Dayana E. Salas-Leiva, Eelco C. Tromer, Bruce A. Curtis, Jon Jerlström-Hultqvist, Martin Kolisko, Zhenzhen Yi, Joan S. Salas-Leiva, Lucie Gallot-Lavallée, Shelby K. Williams, Geert J. P. L. Kops, John M. Archibald, Alastair G. B. Simpson, Andrew J. Roger
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
Externí odkaz:
https://doaj.org/article/4f649da9574b44878fcbb40345fe2a83
Autor:
Dayana E. Salas-Leiva, Eelco C. Tromer, Bruce A. Curtis, Jon Jerlström-Hultqvist, Martin Kolisko, Zhenzhen Yi, Joan S. Salas-Leiva, Lucie Gallot-Lavallée, Shelby K. Williams, Geert J. P. L. Kops, John M. Archibald, Alastair G. B. Simpson, Andrew J. Roger
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The mechanisms for replicating and segregating DNA are highly conserved across eukaryotes. A comparative genomic analysis of a free-living protist finds a surprising lack of protein complexes involved in these processes, suggesting that the organism
Externí odkaz:
https://doaj.org/article/53b88dba845e440e95e7fa4a170fb0c8
Autor:
Erik van Dijk, Tom van den Bosch, Kristiaan J. Lenos, Khalid El Makrini, Lisanne E. Nijman, Hendrik F. B. van Essen, Nico Lansu, Michiel Boekhout, Joris H. Hageman, Rebecca C. Fitzgerald, Cornelis J. A. Punt, Jurriaan B. Tuynman, Hugo J. G. Snippert, Geert J. P. L. Kops, Jan Paul Medema, Bauke Ylstra, Louis Vermeulen, Daniël M. Miedema
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Intratumour heterogeneity (ITH) is associated with worse prognosis in cancer, and efficient frameworks to measure it are needed. Here the authors develop a method to estimate copy number heterogeneity, and propose that it is driven by chromosomal ins
Externí odkaz:
https://doaj.org/article/264d1331d97845559b189b69b84d9dcb
Autor:
Wilma H. M. Hoevenaar, Aniek Janssen, Ajit I. Quirindongo, Huiying Ma, Sjoerd J. Klaasen, Antoinette Teixeira, Bastiaan van Gerwen, Nico Lansu, Folkert H. M. Morsink, G. Johan A. Offerhaus, René H. Medema, Geert J. P. L. Kops, Nannette Jelluma
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Aneuploidy caused by chromosomal instability is frequently observed in cancer, but little is known about its contribution to tumor development. Here, the authors show that in the mouse intestine, the consequences of aneuploidy are exquisitely depende
Externí odkaz:
https://doaj.org/article/118f25f0a18f4b6ea689450fb6a3c626
Autor:
Sjoerd J. Klaasen, Geert J. P. L. Kops
Publikováno v:
Cells, Vol 11, Iss 22, p 3564 (2022)
Aneuploidy is a hallmark of cancer and a major cause of miscarriages in humans. It is caused by chromosome segregation errors during cell divisions. Evidence is mounting that the probability of specific chromosomes undergoing a segregation error is n
Externí odkaz:
https://doaj.org/article/1d4cce1dc02349f3950f685659fd19bb