Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Geert J L H van Leenders"'
Autor:
Melissa Vos, Ruben Boers, Anne L M Vriends, Joachim Boers, Patricia F van Kuijk, Winan J van Houdt, Geert J L H van Leenders, Michal Wagrodzki, Wilfred F J van IJcken, Joost Gribnau, Dirk J Grünhagen, Cornelis Verhoef, Stefan Sleijfer, Erik A C Wiemer
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0228014 (2020)
Approximately one-third of the patients with well-differentiated liposarcoma (WDLPS) will develop a local recurrence. Not much is known about the molecular relationship between the primary tumor and the recurrent tumor, which is important to reveal p
Externí odkaz:
https://doaj.org/article/ed7c1158aab044249ae0a4a5efa1bab2
Autor:
Maud Rijnders, J. Alberto Nakauma-González, Debbie G. J. Robbrecht, Alberto Gil-Jimenez, Hayri E. Balcioglu, Astrid A. M. Oostvogels, Maureen J. B. Aarts, Joost L. Boormans, Paul Hamberg, Michiel S. van der Heijden, Bernadett E. Szabados, Geert J. L. H. van Leenders, Niven Mehra, Jens Voortman, Hans M. Westgeest, Ronald de Wit, Astrid A. M. van der Veldt, Reno Debets, Martijn P. Lolkema
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Immune checkpoint inhibitors (ICI) improve overall survival in patients with metastatic urothelial cancer (mUC), but therapeutic success at the individual patient level varies significantly. Here we identify predictive markers of response, b
Externí odkaz:
https://doaj.org/article/5c826962a5fb45ffbb47fc08f0218098
Autor:
Kishan A T Naipal, Anja Raams, Serena T Bruens, Inger Brandsma, Nicole S Verkaik, Nicolaas G J Jaspers, Jan H J Hoeijmakers, Geert J L H van Leenders, Joris Pothof, Roland Kanaar, Joost Boormans, Dik C van Gent
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0126029 (2015)
Bladder cancer has a high incidence with significant morbidity and mortality. Attenuated expression of the DNA damage response protein Xeroderma Pigmentosum complementation group C (XPC) has been described in bladder cancer. XPC plays an essential ro
Externí odkaz:
https://doaj.org/article/ea3f2b994d0f42af98b9ca103f83e8f6
Autor:
Geert J L H van Leenders, Rajesh Sookhlall, Wilma J Teubel, Corrina M A de Ridder, Suzanne Reneman, Andrea Sacchetti, Kees J Vissers, Wytske van Weerden, Guido Jenster
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e26753 (2011)
Prostate cancer consists of secretory cells and a population of immature cells. The function of immature cells and their mutual relation with secretory cells are still poorly understood. Immature cells either have a hierarchical relation to secretory
Externí odkaz:
https://doaj.org/article/431f6bd87c96437da1fa61c2a6d7647f
Publikováno v:
Histopathology, 82(7), 1089-1097. Wiley-Blackwell Publishing Ltd
Aims: Grade Group 5 (GG5) prostate cancer (PCa) is associated with a high risk of disease recurrence after radical prostatectomy (~75% at 5 years). However, this is a heterogeneous category that includes neoplasms with different combinations of Gleas
Autor:
Margaretha A. van der Slot, Neslisah Seyrek, Charlotte F. Kweldam, Michael A. den Bakker, Martijn B. Busstra, Melanie Gan, Sjoerd Klaver, John B. W. Rietbergen, Geert J. L. H. van Leenders
Publikováno v:
World Journal of Urology, 40(11), 2723-2729. Springer-Verlag
Purpose To identify parameters to predict upgrading in biopsy Grade Group (GG) 2 prostate cancer patients without cribriform and intraductal carcinoma (CR/IDC) on biopsy. Methods Preoperative biopsies from 657 men undergoing radical prostatectomy (RP
Publikováno v:
Histopathology.
Cribriform architecture has been recognised as an independent parameter for prostate cancer outcome. Little is yet known on the added value of individual Gleason 5 growth patterns. Comedonecrosis is assigned Gleason pattern 5 and can occur in both in
Autor:
Jasmijn Vaneman, Heleen J. van Beekhuizen, Joost L. Boormans, Patricia C. Ewing-Graham, Geert J. L. H. van Leenders, Ramon G. V. Smolders, H C. van Doorn
Publikováno v:
Virchows Archiv. Springer-Verlag
Diagnosis of lymph node metastases in pelvic lymph node dissection (PLND) is important for staging and treatment. Standard practice is to submit visible or palpable lymph nodes for histology. We assessed the added value of embedding all residual fatt
Autor:
Lars Egevad, Brett Delahunt, Kenneth A Iczkowski, Theo van der Kwast, Geert J L H van Leenders, Katia R M Leite, Chin‐Chen Pan, Hemamali Samaratunga, Toyonori Tsuzuki, Nita Mulliqi, Xiaoyi Ji, Henrik Olsson, Masi Valkonen, Pekka Ruusuvuori, Martin Eklund, Kimmo Kartasalo
Publikováno v:
Histopathology, 82(6), 837-845. Wiley-Blackwell Publishing Ltd
Aims: There is strong evidence that cribriform morphology indicates a worse prognosis of prostatic adenocarcinoma. Our aim was to investigate its interobserver reproducibility in prostate needle biopsies. Methods and results: A panel of nine prostate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10589eb76c53044786f004e6afc7f32e
https://pure.eur.nl/en/publications/2dfa74a9-ab0a-4625-89ff-f2f707322414
https://pure.eur.nl/en/publications/2dfa74a9-ab0a-4625-89ff-f2f707322414
Autor:
Irma van de Beek, Iris E. Glykofridis, Anja Wagner, Dorine T. den Toom, Ernie M. H. F. Bongers, Geert J. L. H. van Leenders, Paul C. Johannesma, Hanne E. J. Meijers‐Heijboer, Rob M. F. Wolthuis, Maurice A. M. van Steensel, Hendrikus J. Dubbink, Arjan C. Houweling
Publikováno v:
Molecular Genetics and Genomic Medicine. John Wiley and Sons Inc.
van de Beek, I, Glykofridis, I E, Wagner, A, den Toom, D T, Bongers, E M H F, van Leenders, G J L H, Johannesma, P C, Meijers-Heijboer, H E J, Wolthuis, R M F, van Steensel, M A M, Dubbink, H J & Houweling, A C 2022, ' Combined germline pathogenic variants in FLCN and TP53 are associated with early onset renal cell carcinoma and brain tumors ', Molecular Genetics and Genomic Medicine . https://doi.org/10.1002/mgg3.2098
Molecular Genetics and Genomic Medicine, 11(2):e2098. John Wiley & Sons Inc.
Molecular Genetics & Genomic Medicine, 11
Molecular Genetics & Genomic Medicine, 11, 2
van de Beek, I, Glykofridis, I E, Wagner, A, den Toom, D T, Bongers, E M H F, van Leenders, G J L H, Johannesma, P C, Meijers-Heijboer, H E J, Wolthuis, R M F, van Steensel, M A M, Dubbink, H J & Houweling, A C 2022, ' Combined germline pathogenic variants in FLCN and TP53 are associated with early onset renal cell carcinoma and brain tumors ', Molecular Genetics and Genomic Medicine . https://doi.org/10.1002/mgg3.2098
Molecular Genetics and Genomic Medicine, 11(2):e2098. John Wiley & Sons Inc.
Molecular Genetics & Genomic Medicine, 11
Molecular Genetics & Genomic Medicine, 11, 2
Contains fulltext : 291168.pdf (Publisher’s version ) (Open Access) BACKGROUND: We present a family consisting of a father and his two children with an exceptional phenotype of childhood renal cell carcinoma and brain tumors. Extensive genetic test