Zobrazeno 1 - 10
of 242
pro vyhledávání: '"Geert, Carmeliet"'
Autor:
Stefanie Doms, Lieve Verlinden, Iris Janssens, Justine Vanhevel, Roy Eerlings, René Houtman, Shigeaki Kato, Chantal Mathieu, Brigitte Decallonne, Geert Carmeliet, Annemieke Verstuyf
Publikováno v:
Bone Research, Vol 12, Iss 1, Pp 1-13 (2024)
Abstract The vitamin D receptor (VDR) plays a critical role in the regulation of mineral and bone homeostasis. Upon binding of 1α,25-dihydroxyvitamin D3 to the VDR, the activation function 2 (AF2) domain repositions and recruits coactivators for the
Externí odkaz:
https://doaj.org/article/f27a6b6d0cb449ae93888a4d081135ad
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionDue to the relatively long life span of rodent models, in order to expediate the identification of novel therapeutics of age related diseases, mouse models of accelerated aging have been developed. In this study we examined skeletal chang
Externí odkaz:
https://doaj.org/article/ec71a6aba2cc46458b1bcd6c26a7a449
Autor:
Ernestina Schipani, Geert Carmeliet
Publikováno v:
Bone Reports, Vol 19, Iss , Pp 101719- (2023)
Externí odkaz:
https://doaj.org/article/5416d2b5c587476fa7722a98d3410ff0
Autor:
Megan L. Noonan, Pu Ni, Emmanuel Solis, Yamil G. Marambio, Rafiou Agoro, Xiaona Chu, Yue Wang, Hongyu Gao, Xiaoling Xuei, Erica L. Clinkenbeard, Guanglong Jiang, Sheng Liu, Steve Stegen, Geert Carmeliet, William R. Thompson, Yunlong Liu, Jun Wan, Kenneth E. White
Publikováno v:
Bone Research, Vol 11, Iss 1, Pp 1-15 (2023)
Abstract Osteocytes act within a hypoxic environment to control key steps in bone formation. FGF23, a critical phosphate-regulating hormone, is stimulated by low oxygen/iron in acute and chronic diseases, however the molecular mechanisms directing th
Externí odkaz:
https://doaj.org/article/f17e71dfa7c9425683b7aececc78f2ae
Autor:
Lieve Verlinden, Stefanie Doms, Iris Janssens, Mark B. Meyer, J. Wesley Pike, Geert Carmeliet, Annemieke Verstuyf
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionNeuropilin 2 (NRP2) mediates the effects of class 3 semaphorins and vascular endothelial growth factor and is implicated in axonal guidance and angiogenesis. Moreover, NRP2 expression is suggested to be involved in the regulation of bone
Externí odkaz:
https://doaj.org/article/ebe7e524e4a4478983c68aea0c4b42f5
Autor:
Steve Stegen, Shauni Loopmans, Ingrid Stockmans, Karen Moermans, Peter Carmeliet, Geert Carmeliet
Publikováno v:
Bone Research, Vol 10, Iss 1, Pp 1-12 (2022)
Abstract The majority of the mammalian skeleton is formed through endochondral ossification starting from a cartilaginous template. Cartilage cells, or chondrocytes, survive, proliferate and synthesize extracellular matrix in an avascular environment
Externí odkaz:
https://doaj.org/article/f16d4047c6c64d6892beb8d479038f8e
Publikováno v:
Bone Reports, Vol 17, Iss , Pp 101620- (2022)
Amino acid metabolism regulates essential cellular functions, not only by fueling protein synthesis, but also by supporting the biogenesis of nucleotides, redox factors and lipids. Amino acids are also involved in tricarboxylic acid cycle anaplerosis
Externí odkaz:
https://doaj.org/article/33f9570d271f42f5b12319e9a0395857
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Skeletal stem and progenitor cells (SSPCs) constitute a reservoir of bone-forming cells necessary for bone development, modeling and remodeling, as well as for fracture healing. Recent advances in tools to identify and isolate SSPCs have revealed tha
Externí odkaz:
https://doaj.org/article/9593556425e04ac6bbe24e8965dfb84e
Autor:
Guillaume Tournaire, Shauni Loopmans, Steve Stegen, Gianmarco Rinaldi, Guy Eelen, Sophie Torrekens, Karen Moermans, Peter Carmeliet, Bart Ghesquière, Bernard Thienpont, Sarah-Maria Fendt, Nick van Gastel, Geert Carmeliet
Publikováno v:
Cell Reports, Vol 40, Iss 4, Pp 111105- (2022)
Summary: A functional electron transport chain (ETC) is crucial for supporting bioenergetics and biosynthesis. Accordingly, ETC inhibition decreases proliferation in cancer cells but does not seem to impair stem cell proliferation. However, it remain
Externí odkaz:
https://doaj.org/article/1c265b47dd804462b08881f936fd1519
Autor:
Catarina Meng, Hanne Skou Jørgensen, Lieve Verlinden, Nathalie Bravenboer, Henriette de Loor, Patrick C. D'Haese, Geert Carmeliet, Pieter Evenepoel
Publikováno v:
Bone Reports, Vol 16, Iss , Pp 101172- (2022)
Bone microarchitecture is an important component of bone quality and disturbances may reduce bone strength and resistance to trauma. Kidney transplant recipients have an excess risk of fractures, and bone loss affecting both trabecular and cortical b
Externí odkaz:
https://doaj.org/article/60f320836ea749d299c5a1a3190b0dc1