Zobrazeno 1 - 10
of 315
pro vyhledávání: '"Geert, Bultynck"'
Autor:
Rudy Gadet, Lea Jabbour, Trang Thi Minh Nguyen, Olivier Lohez, Ivan Mikaelian, Philippe Gonzalo, Tomas Luyten, Mounira Chalabi-Dchar, Anne Wierinckx, Olivier Marcillat, Geert Bultynck, Ruth Rimokh, Nikolay Popgeorgiev, Germain Gillet
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Apoptosis plays a role in cell homeostasis in both normal development and disease. Bcl-xL, a member of the Bcl-2 family of proteins, regulates the intrinsic mitochondrial pathway of apoptosis. It is overexpressed in several cancers. Bcl-xL h
Externí odkaz:
https://doaj.org/article/34c348a12fb44ef2916bea077f155ce7
Autor:
Mailis Liiv, Annika Vaarmann, Dzhamilja Safiulina, Vinay Choubey, Ruby Gupta, Malle Kuum, Lucia Janickova, Zuzana Hodurova, Michal Cagalinec, Akbar Zeb, Miriam A. Hickey, Yi-Long Huang, Nana Gogichaishvili, Merle Mandel, Mario Plaas, Eero Vasar, Jens Loncke, Tim Vervliet, Ting-Fen Tsai, Geert Bultynck, Vladimir Veksler, Allen Kaasik
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Wolfram syndrome is a rare genetic disease caused by mutations in the WFS1 or CISD2 gene. A primary defect in Wolfram syndrome involves poor ER Ca2+ handling, but how this disturbance leads to the disease is not known. The current study, per
Externí odkaz:
https://doaj.org/article/7119060b6c6844ed9cd995417943a2ed
Autor:
Femke Speelman-Rooms, Maarten Vanmunster, Aled Coughlan, Macarena Hinrichs, Ilaria Pontisso, Solene Barbeau, Thibaud Parpaite, Geert Bultynck, Malene Brohus
Publikováno v:
Biology Open, Vol 13, Iss 4 (2024)
Externí odkaz:
https://doaj.org/article/9ad6160f44444596878e299143f724e9
Autor:
Flore Sneyers, Martijn Kerkhofs, Femke Speelman-Rooms, Kirsten Welkenhuyzen, Rita La Rovere, Ahmed Shemy, Arnout Voet, Guy Eelen, Mieke Dewerchin, Stephen W. G. Tait, Bart Ghesquière, Martin D. Bootman, Geert Bultynck
Publikováno v:
Cell Death and Disease, Vol 14, Iss 9, Pp 1-17 (2023)
Abstract Intracellular Ca2+ signals control several physiological and pathophysiological processes. The main tool to chelate intracellular Ca2+ is intracellular BAPTA (BAPTAi), usually introduced into cells as a membrane-permeant acetoxymethyl ester
Externí odkaz:
https://doaj.org/article/165f5a0201694ead8a06898f90b65886
Autor:
Elżbieta Kania, Jaclyn S. Long, David G. McEwan, Kirsten Welkenhuyzen, Rita La Rovere, Tomas Luyten, John Halpin, Evy Lobbestael, Veerle Baekelandt, Geert Bultynck, Kevin M. Ryan, Jan B. Parys
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-14 (2023)
Abstract Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic cause of Parkinson’s disease (PD), with growing importance also for Crohn’s disease and cancer. LRRK2 is a large and complex protein possessing both G
Externí odkaz:
https://doaj.org/article/ac990b44ebe440e7985118a7bf10125c
Autor:
George Shapovalov, Abigaël Ritaine, Nadege Charlene Essonghe, Ian de Ridder, Hristina Ivanova, Spyridoula Karamanou, Anastassios Economou, Geert Bultynck, Roman Skryma, Natalia Prevarskaya
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 3, Iss 3, Pp 375-391 (2022)
Aim: Inositol 1,4,5-trisphosphate receptor (IP3R) is a ubiquitous calcium (Ca2+) channel involved in the regulation of cellular fate and motility. Its modulation by anti-apoptotic protein B-cell lymphoma 2 (Bcl-2) plays an important role in cancer p
Externí odkaz:
https://doaj.org/article/73e4e5fee9d446719a9acd7095970303
Autor:
Luc Leybaert, Maarten A.J. De Smet, Alessio Lissoni, Rosalie Allewaert, H. Llewelyn Roderick, Geert Bultynck, Mario Delmar, Karin R. Sipido, Katja Witschas
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 6 (2023)
Connexins are crucial cardiac proteins that form hemichannels and gap junctions. Gap junctions are responsible for the propagation of electrical and chemical signals between myocardial cells and cells of the specialized conduction system in order to
Externí odkaz:
https://doaj.org/article/c31bdf27fc3543e5b9392e8b80979d2e
Publikováno v:
Cells, Vol 12, Iss 21, p 2527 (2023)
Pyruvate kinase M (PKM) 2 was described to interact with the inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) and suppress its activity. To further investigate the physiological importance of the PKM2:IP3R interaction, we developed and characterize
Externí odkaz:
https://doaj.org/article/27ab4587af484dc7a6da653475295f8a
Publikováno v:
BBA Advances, Vol 4, Iss , Pp 100105- (2023)
INPP5K (inositol polyphosphate 5-phosphatase K) is an endoplasmic reticulum (ER)-resident enzyme that acts as a phosphoinositide (PI) 5-phosphatase, capable of dephosphorylating various PIs including PI 4,5-bisphosphate (PI(4,5)P2), a key phosphoinos
Externí odkaz:
https://doaj.org/article/e39116bb13b34679bdd8ad09b7fdb31d
Autor:
Lara E. Terry, Vikas Arige, Julika Neumann, Amanda M. Wahl, Taylor R. Knebel, James W. Chaffer, Sundeep Malik, Adrian Liston, Stephanie Humblet-Baron, Geert Bultynck, David I. Yule
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105523- (2022)
Summary: Mutations in all subtypes of the inositol 1,4,5-trisphosphate receptor Ca2+ release channel are associated with human diseases. In this report, we investigated the functionality of three neuropathy-associated missense mutations in IP3R3 (V61
Externí odkaz:
https://doaj.org/article/8a4e8aa047b34215abf1d60d404fecd4