Zobrazeno 1 - 10
of 587
pro vyhledávání: '"Geerlof, A"'
Publikováno v:
In Journal of Pharmaceutical and Biomedical Analysis 15 September 2024 248
Autor:
Fabian Giehler, Michael S. Ostertag, Thomas Sommermann, Daniel Weidl, Kai R. Sterz, Helmut Kutz, Andreas Moosmann, Stephan M. Feller, Arie Geerlof, Brigitte Biesinger, Grzegorz M. Popowicz, Johannes Kirchmair, Arnd Kieser
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) drives viral B cell transformation and oncogenesis. LMP1’s transforming activity depends on its C-terminal activation region 2 (CTAR2), which induces NF-κB and JNK by engaging TNF
Externí odkaz:
https://doaj.org/article/6129e63ef175431f88dcfe4bca0f1328
Autor:
Komal Soni, Pravin Kumar Ankush Jagtap, Santiago Martínez-Lumbreras, Sophie Bonnal, Arie Geerlof, Ralf Stehle, Bernd Simon, Juan Valcárcel, Michael Sattler
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The RNA-binding motif protein RBM5 belongs to a family of multi-domain RNA binding proteins that regulate alternative splicing of genes important for apoptosis and cell proliferation and have been implicated in cancer. RBM5 harbors structura
Externí odkaz:
https://doaj.org/article/f91497348f68452ea6ee9cd287e24528
Akademický článek
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Autor:
Angelo Ferreira Chora, Dora Pedroso, Eleni Kyriakou, Nadja Pejanovic, Henrique Colaço, Raffaella Gozzelino, André Barros, Katharina Willmann, Tiago Velho, Catarina F Moita, Isa Santos, Pedro Pereira, Silvia Carvalho, Filipa Batalha Martins, João A Ferreira, Sérgio Fernandes de Almeida, Vladimir Benes, Josef Anrather, Sebastian Weis, Miguel P Soares, Arie Geerlof, Jacques Neefjes, Michael Sattler, Ana C Messias, Ana Neves-Costa, Luis Ferreira Moita
Publikováno v:
eLife, Vol 11 (2022)
Anthracyclines are among the most used and effective anticancer drugs. Their activity has been attributed to DNA double-strand breaks resulting from topoisomerase II poisoning and to eviction of histones from select sites in the genome. Here, we show
Externí odkaz:
https://doaj.org/article/32ef11be914c4b2e932acba420ab64bc
Autor:
Kai P. Hoefig, Alexander Reim, Christian Gallus, Elaine H. Wong, Gesine Behrens, Christine Conrad, Meng Xu, Lisa Kifinger, Taku Ito-Kureha, Kyra A. Y. Defourny, Arie Geerlof, Josef Mautner, Stefanie M. Hauck, Dirk Baumjohann, Regina Feederle, Matthias Mann, Michael Wierer, Elke Glasmacher, Vigo Heissmeyer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
An extensive RNA binding protein atlas (RBPome) for primary T cells would be a useful resource. Here the authors use two different methods to characterise the mouse and human T cell RBPome and show regulation of Roquin-1/2 dependent and independent p
Externí odkaz:
https://doaj.org/article/79f61fbb2db9463391f56fc5ab732e2e
Autor:
Anastasia Georgiadi, Valeria Lopez-Salazar, Rabih El- Merahbi, Rhoda Anane Karikari, Xiaochuan Ma, André Mourão, Katarina Klepac, Lea Bühler, Ana Jimena Alfaro, Isabell Kaczmarek, Adam Linford, Madeleen Bosma, Olga Shilkova, Olli Ritvos, Nobuhiro Nakamura, Shigehisa Hirose, Maximilian Lassi, Raffaele Teperino, Juliano Machado, Marcel Scheideler, Arne Dietrich, Arie Geerlof, Annette Feuchtinger, Andreas Blutke, Katrin Fischer, Timo Dirk Müller, Katharina Kessler, Torsten Schöneberg, Doreen Thor, Silke Hornemann, Michael Kruse, Peter Nawroth, Olga Pivovarova-Ramich, Andreas Friedrich Hermann Pfeiffer, Michael Sattler, Matthias Blüher, Stephan Herzig
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
The soluble bioactive form of the transmembrane protein fibronectin type III domain containing 4 (sFNDC4) has anti-inflammatory effects and improves insulin sensitivity. Here the authors show that liver derived sFNDC4 signals through adipose tissue G
Externí odkaz:
https://doaj.org/article/899459e9671c4eeca6889de131d50098
Akademický článek
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Autor:
Anna Hillenmayer, Christian M. Wertheimer, Arie Geerlof, Kirsten H. Eibl, Siegfried Priglinger, Claudia Priglinger, Andreas Ohlmann
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
Purpose Galectin-1 and -3 are β-galactoside binding lectins with varying effects on angiogenesis and apoptosis. Since in retinal pigment epithelial cells high amounts of human recombinant galectin (hr-GAL)1 and 3 inhibit cell adhesion, migration and
Externí odkaz:
https://doaj.org/article/708c0218c5024570ada12cdbbc9c7222
Autor:
Enrica Zanuttigh, Kevork Derderian, Miriam A. Güra, Arie Geerlof, Ivano Di Meo, Chiara Cavestro, Stefan Hempfling, Stephanie Ortiz-Collazos, Mario Mauthe, Tomasz Kmieć, Eugenia Cammarota, Maria Carla Panzeri, Thomas Klopstock, Michael Sattler, Juliane Winkelmann, Ana C. Messias, Arcangela Iuso
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 267 (2023)
Mitochondrial membrane protein-associated neurodegeneration (MPAN) is a relentlessly progressive neurodegenerative disorder caused by mutations in the C19orf12 gene. C19orf12 has been implicated in playing a role in lipid metabolism, mitochondrial fu
Externí odkaz:
https://doaj.org/article/08ddda2e943348d48dfa60c232cfa9f8