Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Geen-Dong Chang"'
Autor:
Liang-Jie Wang, Chie-Pein Chen, Yun-Shien Lee, Pui-Sze Ng, Geen-Dong Chang, Yu-Hsuan Pao, Hsiao-Fan Lo, Chao-Hsiang Peng, Mei-Leng Cheong, Hungwen Chen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Trophoblast stem cells can be derived from human blastocysts and first-trimester, but not term, cytotrophoblasts. Here the authors show that induction efficiency of cytotrophoblast is determined by antagonism between GCM1 and ΔNp63α and manipulatin
Externí odkaz:
https://doaj.org/article/f1760c12c36e4495b73d44811c3197a6
Autor:
Chih-Ying Lee, Guan-Chin Su, Wen-Yen Huang, Min-Yu Ko, Hsin-Yi Yeh, Geen-Dong Chang, Sung-Jan Lin, Peter Chi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The maintenance polyamines homeostasis is important for cell growth, and several cancers harbor elevated levels of polyamines that may contribute to sustained proliferative potential. Here the authors demonstrate that polyamines participate in DNA do
Externí odkaz:
https://doaj.org/article/7905654691784a7b98c5c9e821361d5d
Publikováno v:
Antioxidants, Vol 10, Iss 2, p 326 (2021)
Methylglyoxal (MG) is a reactive glycation metabolite and potentially induces dicarbonyl stress. The production of MG in cells is increased along with an increase in carbohydrate metabolism. The efficiency of the glyoxalase system, consisting of glyo
Externí odkaz:
https://doaj.org/article/8c838e8eb07c492f8ed4aece7511b689
Autor:
Der-Yen Lee, Geen-Dong Chang
Publikováno v:
Redox Biology, Vol 2, Iss C, Pp 196-205 (2014)
Glyoxalase 1 (GlxI) is the key enzyme that converts the highly reactive α-oxo-aldehydes into the corresponding α-hydroxy acids using l-glutathione as a cofactor. In our preliminary data, GlxI was identified as a substrate of transglutaminase 2 (TG2
Externí odkaz:
https://doaj.org/article/d2eccfa116674dcb961bad3112190eb6
Autor:
Mei-An Su, Yun-Tzu Huang, I-Tung Chen, Der-Yen Lee, Yun-Chieh Hsieh, Chun-Yuan Li, Tze Hann Ng, Suh-Yuen Liang, Shu-Yu Lin, Shiao-Wei Huang, Yi-An Chiang, Hon-Tsen Yu, Kay-Hooi Khoo, Geen-Dong Chang, Chu-Fang Lo, Han-Ching Wang
Publikováno v:
PLoS Pathogens, Vol 10, Iss 6, p e1004196 (2014)
In this study, we used a systems biology approach to investigate changes in the proteome and metabolome of shrimp hemocytes infected by the invertebrate virus WSSV (white spot syndrome virus) at the viral genome replication stage (12 hpi) and the lat
Externí odkaz:
https://doaj.org/article/bc700c6a000f4d76beffb3323cb67691
Autor:
Pei-Yu Chiang, Yu-Fang Shen, Yu-Lun Su, Ching-Han Kao, Nien-Yi Lin, Pang-Hung Hsu, Ming-Daw Tsai, Shun-Chang Wang, Geen-Dong Chang, Sheng-Chung Lee, Ching-Jin Chang
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61697 (2013)
BackgroundTurnover of mRNA is a critical step in the regulation of gene expression, and an important step in mRNA decay is removal of the 5' cap. We previously demonstrated that the expression of some immediate early gene mRNAs is controlled by RNA s
Externí odkaz:
https://doaj.org/article/6a5bff4fe9ad46d0907fcc1b9c418f5d
Autor:
Su-Jung Yang, Chen-Yu Chen, Geen-Dong Chang, Hui-Chin Wen, Ching-Yu Chen, Shi-Chuan Chang, Jyh-Fei Liao, Chung-Ho Chang
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58100 (2013)
Diabetes is characterized by chronic hyperglycemia, which in turn facilitates the formation of advanced glycation end products (AGEs). AGEs activate signaling proteins such as Src, Akt and ERK1/2. However, the mechanisms by which AGEs activate these
Externí odkaz:
https://doaj.org/article/3371b838bf234e1d996f0ede02c18ecf
Autor:
Yu-Lun Su, Shun-Chang Wang, Pei-Yu Chiang, Nien-Yi Lin, Yu-Fang Shen, Geen-Dong Chang, Ching-Jin Chang
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41313 (2012)
BACKGROUND: Tristetraprolin binds mRNA AU-rich elements and thereby facilitates the destabilization of mature mRNA in the cytosol. METHODOLOGY/PRINCIPAL FINDINGS: To understand how tristetraprolin mechanistically functions, we biopanned with a phage-
Externí odkaz:
https://doaj.org/article/3ce40d32975c479684157f240bbe377f
Autor:
Kai-Yun Huang, Gen-Der Chen, Chia-Hsiung Cheng, Kuan-Ya Liao, Chin-Chun Hung, Geen-Dong Chang, Pung-Pung Hwang, Shu-Yu Lin, Ming-Chieh Tsai, Kay-Hooi Khoo, Ming-Ting Lee, Chang-Jen Huang
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26461 (2011)
BACKGROUND:Mammalian M6A, a member of the proteolipid protein (PLP/DM20) family expressed in neurons, was first isolated by expression cloning with a monoclonal antibody. Overexpression of M6A was shown to induce filopodium formation in neuronal cell
Externí odkaz:
https://doaj.org/article/783add14a8284474bd679b4cb719ad7c
Autor:
Geen-Dong Chang, Ming-Shyue Lee, Chao-Chi Ho, Santiago Ramón-Maiques, Francisco Del Caño-Ochoa, Ya-Hui Chuang, I-Chun Chen, Der-Yen Lee, Chia-Chi Ku, Hsin-Ying Lin, Hsin-Hsien Lin, Shao-Wei Lan, Cheng-Fan Lee, Ching-Tai Lee, Chun-Jung Ko, Hsin-Fang Tu
Current clinical trials of combined EGFR-tyrosine kinase inhibitors (TKI) and immune checkpoint blockade (ICB) therapies show no additional effect. This raises questions regarding whether EGFR-TKIs attenuate ICB-enhanced CD8+ T lymphocyte function. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db98134cf3aa0654ea889866ceb5042
https://doi.org/10.1158/0008-5472.c.6513067
https://doi.org/10.1158/0008-5472.c.6513067