Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Gee Ann Toh"'
Autor:
Kim S. ROBINSON, Gee Ann TOH, Muhammad Jasrie FIRDAUS, Khek Chian THAM, Pritisha ROZARIO, Chrissie LIM, Ying Xiu TOH, Zhi Heng LAU, Sophie Charlotte BINDER, Jacob MAYER, Carine BONNARD, Florian I. SCHMIDT, John E. A. COMMON, Franklin L. ZHONG
NLRP1 is an innate immune sensor protein that activates inflammasome-driven pyroptotic cell death. Recent work demonstrates that human NLRP1 has evolved to sense viral infections. Whether and how human NLRP1 responds to other infectious agents is unc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad76428c5948ff4f0a10289c3b7465b3
https://doi.org/10.1101/2023.01.16.524188
https://doi.org/10.1101/2023.01.16.524188
Autor:
Miriam Pinilla, Raoul Mazars, Romain Vergé, Leana Gorse, Karin Santoni, Kim Samirah Robinson, Gee Ann Toh, Laure Prouvensier, Stephen Adonai LeonIcaza, Audrey Hessel, David Péricat, Marlène Murris, Anthony Henras, Julien Buyck, Céline Cougoule, Emmanuel Ravet, Franklin L. Zhong, Rémi Planès, Etienne Meunier
The intracellular inflammasome complex have been implicated in the maladaptive tissue damage and inflammation observed in chronicPseudomonas aeruginosainfection. Human airway and corneal epithelial cells, which are critically altered during chronic i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e5c2ec1301685e15d88eabc96054ac3
https://doi.org/10.1101/2023.01.16.524164
https://doi.org/10.1101/2023.01.16.524164
Autor:
Rhea Nadkarni, Wern Cui Chu, Cheryl Q.E. Lee, Yasir Mohamud, Lynn Yap, Gee Ann Toh, Sheryl Beh, Radiance Lim, Yiyun Michelle Fan, Yizhuo Lyanne Zhang, Kim Robinson, Karl Tryggvason, Honglin Luo, Franklin Zhong, Lena Ho
Publikováno v:
Journal of Experimental Medicine. 219
Nucleotide-binding oligomerization domain (NBD), leucine-rich repeat (LRR) containing protein family (NLRs) are intracellular pattern recognition receptors that mediate innate immunity against infections. The endothelium is the first line of defense
Autor:
Kim S. Robinson, Gee Ann Toh, Pritisha Rozario, Rae Chua, Stefan Bauernfried, Zijin Sun, Muhammad Jasrie Firdaus, Shima Bayat, Rhea Nadkarni, Zhi Sheng Poh, Khek Chian Tham, Cassandra R. Harapas, Chrissie K. Lim, Werncui Chu, Celest W. S. Tay, Kiat Yi Tan, Tianyun Zhao, Carine Bonnard, Radoslaw Sobota, John E. Connolly, John Common, Seth L. Masters, Kaiwen W. Chen, Lena Ho, Bin Wu, Veit Hornung, Franklin L. Zhong
Publikováno v:
Science
Human NLRP1 (NACHT, LRR, and PYD domain-containing protein 1) is an innate immune sensor predominantly expressed in the skin and airway epithelium. Here, we report that human NLRP1 senses the ultraviolet B (UVB)- and toxin-induced ribotoxic stress re
Autor:
Kim S. Robinson, Gee Ann Toh, Pritisha Rozario, Shima Bayat, Zijin Sun, Stefan Bauernfried, Rhea Nadkarni, Cassandra R. Harapas, Chrissie K. Lim, Werncui Chu, Kiat Yi Tan, Carine Bonnard, Radoslaw Sobota, John E. Connolly, Seth L. Masters, Kaiwen W. Chen, Lena Ho, Veit Hornung, Franklin L. Zhong
Human NLRP1 is a multifunctional inflammasome sensor predominantly expressed in skin and airway epithelium; however its function in skin-specific immunity and its mechanisms of activation are not fully understood. Here we report that human NLRP1 is s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::528d68a0f807bf495e55628698a44052
https://doi.org/10.1101/2022.01.24.477516
https://doi.org/10.1101/2022.01.24.477516
Autor:
Vincent T. K. Chow, Gee Ann Toh, De Yun Wang, Bijin Veonice Au, Justin Jang Hann Chu, Chrissie Lim, Bruno Reversade, Tian Sheng Lew, Daniel Eng Thiam Teo, Hsiao Hui Ong, Kim S. Robinson, Kenneth Lay, Kai Sen Tan, Franklin L. Zhong
Publikováno v:
Science, 370(6521):eaay2002. American Association for the Advancement of Science
A ligand is located, at long last! Members of the Nod-like receptor (NLR) family act as intracellular sensors of infection. Once they recognize pathogen-associated molecular patterns, they assemble into signaling complexes called inflammasomes, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f5b80bbf5b1f17f30313173eb81257
https://pure.amc.nl/en/publications/enteroviral-3c-protease-activates-the-human-nlrp1-inflammasome-in-airway-epithelia(1746fd11-3a9c-4dd4-9eb2-adaf33736a0d).html
https://pure.amc.nl/en/publications/enteroviral-3c-protease-activates-the-human-nlrp1-inflammasome-in-airway-epithelia(1746fd11-3a9c-4dd4-9eb2-adaf33736a0d).html