Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Gediminas Greicius"'
Autor:
Lucy Brunt, Gediminas Greicius, Sally Rogers, Benjamin D. Evans, David M. Virshup, Kyle C. A. Wedgwood, Steffen Scholpp
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Cytonemes are cellular projections known to transfer Wnt ligands between cells, but their regulation remains unclear. Here, the authors show that activation of the planar cell polarity protein Vangl2 generates long and branched cytonemes increasing p
Externí odkaz:
https://doaj.org/article/5ea0c3f9e6304004a8bd71cac78f963e
Autor:
Benjamin Mattes, Yonglong Dang, Gediminas Greicius, Lilian Tamara Kaufmann, Benedikt Prunsche, Jakob Rosenbauer, Johannes Stegmaier, Ralf Mikut, Suat Özbek, Gerd Ulrich Nienhaus, Alexander Schug, David M Virshup, Steffen Scholpp
Publikováno v:
eLife, Vol 7 (2018)
Signaling filopodia, termed cytonemes, are dynamic actin-based membrane structures that regulate the exchange of signaling molecules and their receptors within tissues. However, how cytoneme formation is regulated remains unclear. Here, we show that
Externí odkaz:
https://doaj.org/article/9c85a7ddf36a4601a666711100784529
Autor:
Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr
Supplementary Figures and Materials and Metholds from SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b51e86e9b7513857bdd252443925fa
https://doi.org/10.1158/1535-7163.22485351.v1
https://doi.org/10.1158/1535-7163.22485351.v1
Autor:
Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr
Supplementary Table 2 from SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45515ad58f3fa654f42c307ee91c362b
https://doi.org/10.1158/1535-7163.22485345
https://doi.org/10.1158/1535-7163.22485345
Autor:
Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr
Supplementary Table 1 from SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea26232b2120ba418d9671855d8e245c
https://doi.org/10.1158/1535-7163.22485348.v1
https://doi.org/10.1158/1535-7163.22485348.v1
Autor:
Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr
Supplementary Table 3 from SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab078191ad592debcca47d0ad3279d38
https://doi.org/10.1158/1535-7163.22485342.v1
https://doi.org/10.1158/1535-7163.22485342.v1
Autor:
Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr
Although clinical responses in liquid tumors and certain lymphomas have been reported, the clinical efficacy of histone deacetylase inhibitors in solid tumors has been limited. This may be in part due to the poor pharmacokinetic of these drugs, resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bfd470f6ae571ff56fa8b9560145061
https://doi.org/10.1158/1535-7163.c.6531900
https://doi.org/10.1158/1535-7163.c.6531900
Autor:
Kyle C. A. Wedgwood, Steffen Scholpp, David M. Virshup, Gediminas Greicius, Benjamin D. Evans, Sally L. Rogers, Lucy H. Brunt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
Wnt signaling regulates cell proliferation and cell differentiation as well as migration and polarity during development. However, it is still unclear how the Wnt ligand distribution is precisely controlled to fulfil these functions. Here, we show th
Autor:
Gediminas Greicius, David M. Virshup
Publikováno v:
Differentiation. 108:8-16
Intestinal homeostasis is dependent on the continuous production of differentiated epithelial cells from a sustainable and resilient stem cell compartment. Wnt/β-catenin signaling plays a central role in this process, cooperating with R-spondins, gr
Autor:
Kyle C. A. Wedgwood, Gediminas Greicius, Lucy H. Brunt, David M. Virshup, Steffen Scholpp, Benjamin D. Evans
The Wnt signalling network regulates cell proliferation and cell differentiation as well as migration and polarity in development of multicellular organisms. However, it is still unclear how distribution of Wnt ligands is precisely controlled to fulf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d9b4af3e0f7cd47d353e3526d1e3df5
https://doi.org/10.1101/2020.12.23.424142
https://doi.org/10.1101/2020.12.23.424142