Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Gebhard F X Schertler"'
Autor:
Oliver Tejero, Filip Pamula, Mitsumasa Koyanagi, Takashi Nagata, Pavel Afanasyev, Ishita Das, Xavier Deupi, Mordechai Sheves, Akihisa Terakita, Gebhard F. X. Schertler, Matthew J. Rodrigues, Ching-Ju Tsai
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Opsins are G protein-coupled receptors (GPCRs) that have evolved to detect light stimuli and initiate intracellular signaling cascades. Their role as signal transducers is critical to light perception across the animal kingdom. Opsins covale
Externí odkaz:
https://doaj.org/article/09af03e50c8841df8ba7999da291580f
Autor:
Guillaume Gotthard, Sandra Mous, Tobias Weinert, Raiza Nara Antonelli Maia, Daniel James, Florian Dworkowski, Dardan Gashi, Antonia Furrer, Dmitry Ozerov, Ezequiel Panepucci, Meitian Wang, Gebhard F. X. Schertler, Joachim Heberle, Joerg Standfuss, Przemyslaw Nogly
Publikováno v:
IUCrJ, Vol 11, Iss 5, Pp 792-808 (2024)
Light–oxygen–voltage (LOV) domains are small photosensory flavoprotein modules that allow the conversion of external stimuli (sunlight) into intracellular signals responsible for various cell behaviors (e.g. phototropism and chloroplast relocatio
Externí odkaz:
https://doaj.org/article/0487f96a71db49698c8ff3e32bc949bf
Autor:
Natalie Di Bartolo, Emma L R Compton, Tony Warne, Patricia C Edwards, Christopher G Tate, Gebhard F X Schertler, Paula J Booth
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151582 (2016)
The factors defining the correct folding and stability of integral membrane proteins are poorly understood. Folding of only a few select membrane proteins has been scrutinised, leaving considerable deficiencies in knowledge for large protein families
Externí odkaz:
https://doaj.org/article/0ef8c841adb849ae9f0ed741cb3e29c8
Autor:
Shoji Maeda, Dawei Sun, Ankita Singhal, Marcello Foggetta, Georg Schmid, Joerg Standfuss, Michael Hennig, Roger J P Dawson, Dmitry B Veprintsev, Gebhard F X Schertler
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98714 (2014)
The activation of the G-protein transducin (Gt) by rhodopsin (Rho) has been intensively studied for several decades. It is the best understood example of GPCR activation mechanism and serves as a template for other GPCRs. The structure of the Rho/G p
Externí odkaz:
https://doaj.org/article/8b5da6ab8ec342a3876cec257f4820f5
Autor:
Jennifer L Miller-Gallacher, Rony Nehmé, Tony Warne, Patricia C Edwards, Gebhard F X Schertler, Andrew G W Leslie, Christopher G Tate
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92727 (2014)
The β1-adrenoceptor (β1AR) is a G protein-coupled receptor (GPCR) that is activated by the endogenous agonists adrenaline and noradrenaline. We have determined the structure of an ultra-thermostable β1AR mutant bound to the weak partial agonist cy
Externí odkaz:
https://doaj.org/article/50b41481c95544ee93db8f60e8bb5d68
Autor:
Mayank Vashistha, Niels Breckwoldt, Cecilia M. Casadei, Torben Hannemann, Gebhard F. X. Schertler, Robin Santra
Publikováno v:
Physical Review Research, Vol 6, Iss 4, p 043198 (2024)
Serial femtosecond crystallography (SFX) is a powerful technique for studying ultrafast structural dynamics in matter. However, the analysis of SFX data is challenging and would benefit from a systematic theoretical framework. By employing a quantum-
Externí odkaz:
https://doaj.org/article/f55826c4b134423883122a99ef40b647
Autor:
Marc Emmenegger, Elena De Cecco, David Lamparter, Raphaël P. B. Jacquat, Julien Riou, Dominik Menges, Tala Ballouz, Daniel Ebner, Mathias M. Schneider, Itzel Condado Morales, Berre Doğançay, Jingjing Guo, Anne Wiedmer, Julie Domange, Marigona Imeri, Rita Moos, Chryssa Zografou, Leyla Batkitar, Lidia Madrigal, Dezirae Schneider, Chiara Trevisan, Andres Gonzalez-Guerra, Alessandra Carrella, Irina L. Dubach, Catherine K. Xu, Georg Meisl, Vasilis Kosmoliaptsis, Tomas Malinauskas, Nicola Burgess-Brown, Ray Owens, Stephanie Hatch, Juthathip Mongkolsapaya, Gavin R. Screaton, Katharina Schubert, John D. Huck, Feimei Liu, Florence Pojer, Kelvin Lau, David Hacker, Elsbeth Probst-Müller, Carlo Cervia, Jakob Nilsson, Onur Boyman, Lanja Saleh, Katharina Spanaus, Arnold von Eckardstein, Dominik J. Schaer, Nenad Ban, Ching-Ju Tsai, Jacopo Marino, Gebhard F. X. Schertler, Nadine Ebert, Volker Thiel, Jochen Gottschalk, Beat M. Frey, Regina Reimann, Simone Hornemann, Aaron M. Ring, Tuomas P. J. Knowles, Milo A. Puhan, Christian L. Althaus, Ioannis Xenarios, David I. Stuart, Adriano Aguzzi
Effective public-health measures and vaccination campaigns against SARS-CoV-2 require granular knowledge of population-level immune responses. We developed a Tripartite Automated Blood Immunoassay (TRABI) to assess the IgG response against the ectodo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d830d7146a00b9b1ad9aacbe20cf49
https://ora.ox.ac.uk/objects/uuid:f97882af-9559-474c-a127-d88182b9e8b6
https://ora.ox.ac.uk/objects/uuid:f97882af-9559-474c-a127-d88182b9e8b6
Autor:
Cecilia M. Casadei, Ahmad Hosseinizadeh, Spencer Bliven, Tobias Weinert, Jörg Standfuss, Russell Fung, Gebhard F. X. Schertler, Robin Santra
Publikováno v:
Structural dynamics 10(3), 034101 (2023). doi:10.1063/4.0000178
Structural Dynamics, 10 (3)
Structural Dynamics, 10 (3)
Structural dynamics 10(3), 034101 (2023). doi:10.1063/4.0000178
Low-pass spectral analysis (LPSA) is a recently developed dynamics retrieval algorithm showing excellent retrieval properties when applied to model data affected by extreme incomple
Low-pass spectral analysis (LPSA) is a recently developed dynamics retrieval algorithm showing excellent retrieval properties when applied to model data affected by extreme incomple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89ca19f1bc342fb2dec2864cd6b2790a
Autor:
Diane C. A. Barret, Dina Schuster, Matthew J. Rodrigues, Alexander Leitner, Paola Picotti, Gebhard F. X. Schertler, U. Benjamin Kaupp, Volodymyr M. Korkhov, Jacopo Marino
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 120 (15)
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Calmodulin (CaM) regulates many ion channels to control calcium entry into cells, and mutations that alter this interaction are linked to fatal diseases. The structural basis of CaM regulation remains largely unexplored. In retinal photoreceptors, Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d559989736b821de9d5ec9185bbd0b1f
Publikováno v:
Nature Structural and Molecular Biology
In rod photoreceptors of the retina, the cyclic nucleotide-gated (CNG) channel is composed of three CNGA and one CNGB subunits, and it closes in response to light activation to generate an electrical signal that is conveyed to the brain. Here we repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8737d69abe79412785c9f67dd001c31a
https://doi.org/10.1038/s41594-021-00700-8
https://doi.org/10.1038/s41594-021-00700-8