Beyond the seed: structural basis for supplementary microRNA targeting

Autor: Jessica Sheu-Gruttadauria, Yao Xiao, Ian J. MacRae, Gebert Lfr

microRNAs (miRNA) guide Argonaute proteins to mRNAs targeted for repression. Target recognition occurs primarily through the miRNA seed region, composed of guide (g) nucleotides g2–g8. However, nucleotides beyond the seed are also important for som

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd266cac5cf97092437db61fa98f72a4

Assembly of the bacterial ribosome with circularly permuted rRNA.

Autor: Dong X; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Chemistry, and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Sheng K; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Chemistry, and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Gebert LFR; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Aiyer S; Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.; Graduate School of Biological Sciences, Section of Molecular Biology, University of California San Diego, La Jolla, CA 92093, USA., MacRae IJ; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Lyumkis D; Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.; Graduate School of Biological Sciences, Section of Molecular Biology, University of California San Diego, La Jolla, CA 92093, USA., Williamson JR; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Chemistry, and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2024 Oct 14; Vol. 52 (18), pp. 11254-11265.

miR-122-based therapies select for three distinct resistance mechanisms based on alterations in RNA structure.

Autor: Chahal J; Department of Microbiology & Immunology, McGill University, Montréal, QC H3G 1Y6, Canada., Gebert LFR; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Camargo C; Department of Microbiology & Immunology, McGill University, Montréal, QC H3G 1Y6, Canada., MacRae IJ; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Sagan SM; Department of Microbiology & Immunology, McGill University, Montréal, QC H3G 1Y6, Canada; selena.sagan@mcgill.ca.; Department of Biochemistry, McGill University, Montréal, QC H3G 1Y6, Canada.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Aug 17; Vol. 118 (33).

miR-122 and Ago interactions with the HCV genome alter the structure of the viral 5' terminus.

Autor: Chahal J; Department of Microbiology & Immunology, McGill University, Montréal, QC H3G 1Y6, Canada., Gebert LFR; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Gan HH; Center for Genomics and Systems Biology, Department of Biology, New York University, 12 Waverly Place, New York, NY 10003, USA., Camacho E; Department of Biochemistry, McGill University, Montréal, QC H3G 1Y6, Canada., Gunsalus KC; Center for Genomics and Systems Biology, Department of Biology, New York University, 12 Waverly Place, New York, NY 10003, USA.; Division of Biology, New York University Abu Dhabi, Abu Dhabi, UAE., MacRae IJ; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Sagan SM; Department of Microbiology & Immunology, McGill University, Montréal, QC H3G 1Y6, Canada.; Department of Biochemistry, McGill University, Montréal, QC H3G 1Y6, Canada.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2019 Jun 04; Vol. 47 (10), pp. 5307-5324.

COMRADES determines in vivo RNA structures and interactions.

Autor: Ziv O; Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK. omer.ziv@gurdon.cam.ac.uk.; Department of Genetics, University of Cambridge, Cambridge, UK. omer.ziv@gurdon.cam.ac.uk., Gabryelska MM; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, UK., Lun ATL; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Gebert LFR; Department of Integrative Structural and Computational Biology, the Scripps Research Institute, La Jolla, CA, USA., Sheu-Gruttadauria J; Department of Integrative Structural and Computational Biology, the Scripps Research Institute, La Jolla, CA, USA., Meredith LW; Department of Pathology, University of Cambridge, Cambridge, UK., Liu ZY; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.; School of Medicine (Shenzhen), Sun Yat-sen University, Guangzhou, China., Kwok CK; Department of Chemistry, City University of Hong Kong, Hong Kong, China., Qin CF; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China., MacRae IJ; Department of Integrative Structural and Computational Biology, the Scripps Research Institute, La Jolla, CA, USA., Goodfellow I; Department of Pathology, University of Cambridge, Cambridge, UK., Marioni JC; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK.; Wellcome Sanger Institute, Cambridge, UK., Kudla G; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, UK. gkudla@gmail.com., Miska EA; Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK. eric.miska@gurdon.cam.ac.uk.; Department of Genetics, University of Cambridge, Cambridge, UK. eric.miska@gurdon.cam.ac.uk.; Wellcome Sanger Institute, Cambridge, UK. eric.miska@gurdon.cam.ac.uk.

Publikováno v: Nature methods [Nat Methods] 2018 Oct; Vol. 15 (10), pp. 785-788. Date of Electronic Publication: 2018 Sep 10.