Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease

Autor: Lee, JC, Biasci, D, Roberts, R, Gearry, RB, Mansfield, JC, Ahmad, T, Prescott, NJ, Satsangi, J, Wilson, DC, Jostins, L, Anderson, CA, UK IBD Genetics Consortium, Traherne, JA, Lyons, PA, Parkes, M, Smith, KGC

Publikováno v: Nature Genetics
Lee, J C, Biasci, D, Roberts, R, Gearry, R B, Mansfield, J C, Ahmad, T, Prescott, N J, Satsangi, J, Wilson, D C, Jostins, L, Anderson, C A, Traherne, J A, Lyons, P A & Parkes, M & Smith, K G C 2017, ' Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease ', Nature Genetics, vol. 49, no. 2, pp. 262-268 . https://doi.org/10.1038/ng.3755
Lee, J C, Biasci, D, Roberts, R, Gearry, R B, Mansfield, J C, Ahmad, T, Prescott, N J, Satsangi, J, Wilson, D C, Jostins, L, Anderson, C A, Traherne, J A, Lyons, P A, Parkes, M & Smith, K G C 2017, ' Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease ', Nature Genetics, vol. 49, no. 2, pp. 262-268 . https://doi.org/10.1038/ng.3755

For most immune-mediated diseases, the main determinant of patient well-being is not the diagnosis itself but instead the course that the disease takes over time (prognosis)1,2,3. Prognosis may vary substantially between patients for reasons that are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb9f268f2a110a31109f3a1f0397fd3a

Faecal S100A12 Concentrations Correlate with Mucosal Inflammation More Strongly Than Clinical Symptom Scores in Crohn and #8217;s Disease Patients and #8211; Results of the Novel Biomarkers in Inflammatory Bowel Disease (NBIBD) Project

Autor: Hooper Em, Ashcroft Al, Yeo J, Roberts Rl, Hoskin Ts, Gearry Rb, Day As, Falvey Jf

Publikováno v: Annals of Paediatric Rheumatology. 1:2

Background Inflammatory bowel disease (IBD) lead to significant morbidity amongst the New Zealand population. The gold standard for assessing inflammation is colonoscopy but this is invasive and costly. Clinical assessment is subjective and may not r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8fb7e2f1db9291e46f67a7ba489f45a
https://doi.org/10.5455/apr.112320120523

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