Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Geancarlo Zanatta"'
Autor:
Julio Paulino Daniel, Felipe Pantoja Mesquita, Emerson Lucena Da Silva, Pedro Filho Noronha de Souza, Luina Benevides Lima, Lais Lacerda Brasil de Oliveira, Maria Elisabete Amaral de Moraes, Caroline de Fátima Aquino Moreira-Nunes, Rommel Mario Rodríguez Burbano, Geancarlo Zanatta, Raquel Carvalho Montenegro
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Chronic myeloid leukemia (CML) is caused by constitutively active fusion protein BCR-ABL1, and targeting ABL1 is a promising therapy option. Imatinib, dasatinib, and nilotinib have all been shown to work effectively in clinical trials. ABL1 mutations
Externí odkaz:
https://doaj.org/article/486df2451ce54331aa7dcd637d9d8492
Autor:
Yorran Hardman Araújo Montenegro, Geancarlo Zanatta, André Quincozes-Santos, Guilhian Leipnitz
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Externí odkaz:
https://doaj.org/article/12e0ec5e1f7747daa98869e9e09f0aca
Autor:
Anja Conev, Mauricio Menagatti Rigo, Didier Devaurs, André Faustino Fonseca, Hussain Kalavadwala, Martiela Vaz de Freitas, Cecilia Clementi, Geancarlo Zanatta, Dinler Amaral Antunes, Lydia Kavraki
Proteins are dynamic macromolecules that perform vital functions in cells. A protein structure determines its function, but this structure is not static, as proteins change their conformation to achieve various functions. Understanding the conformati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22fa0ebbcd19faf725e9bb97d8d00ce7
https://doi.org/10.1101/2023.04.24.538094
https://doi.org/10.1101/2023.04.24.538094
Autor:
Ewerton W. S. Caetano, Valder N. Freire, Jaqueline Vieira Carletti, Francisca Joseli Freitas de Sousa, Francisco Lucas Santos de Oliveira, Francisca Fernanda Nunes Azevedo, Geancarlo Zanatta
Publikováno v:
New Journal of Chemistry. 44:20982-20992
The characterization of protein–protein interactions (PPIs) is an important step toward the development of therapeutic strategies. In this regard, the use of quantum calculations combined with protein fragmentation schemes can offer an opportunity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d459f2adc09afaff6ea581ac3362e36
https://doi.org/10.1039/d0nj04099a
https://doi.org/10.1039/d0nj04099a
Autor:
Naara Oliveira Santana Fróes, Uchchhal Bandyopadhyay, Jonatas Martins Negreiro, Thiago de Sousa Fonseca, Fátima Miranda Nunes, Marcos Carlos de Mattos, Geancarlo Zanatta, João Victor de Melo Pereira, Celina de Jesus Guimarães, Claudia do Ó Pessoa, Bruno Poti e Silva, Eric Manoury, Maria Conceição Ferreira Oliveira
Publikováno v:
Molecular Catalysis. 535:112867
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81975b2783bcd0c49f00e95ed1201871
https://doi.org/10.1016/j.mcat.2022.112867
https://doi.org/10.1016/j.mcat.2022.112867
Autor:
Ana Caroline Lustosa de Melo Carvalho, Bruna Rocha de Oliveira, Gledson Vieira Lima, Jonatas Martins Negreiro, Maria Conceição Ferreira Oliveira, Telma Leda Gomes de Lemos, Marcos Reinaldo da Silva, Thiago de Sousa Fonseca, Rayanne Mendes Bezerra, Jose Cleiton Sousa dos Santos, Luciana Rocha Barros Gonçalves, Nathalia Saraiva Rios, Geancarlo Zanatta, Marcos Carlos de Mattos
Publikováno v:
Catalysts; Volume 12; Issue 12; Pages: 1566
The lipase kinetic resolution (KR) of aryloxy-propan-2-yl acetates, via hydrolysis, produced enantiomerically pure/enantioenriched mexiletine intermediates and analogs. Racemic acetates rac-1-(2,6-dimethylphenoxy)propan-2-yl acetate (rac-5a), rac-1-(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d2b4fd80c536260dfd0a22ecbe2b5f
https://doi.org/10.3390/catal12121566
https://doi.org/10.3390/catal12121566
Autor:
Bruno P. Silva, Antonio G.L. Costa, Mauricélio B. da Silva, Ambrósio M. Cunha, Regina C.R. Santos, Antoninho Valentini, Geancarlo Zanatta, Pedro de Lima-Neto, Ewerton W.S. Caetano, V.N. Freire
Publikováno v:
Journal of Physics and Chemistry of Solids. 170:110958
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bbccf2c76501c974096f094c8aead38
https://doi.org/10.1016/j.jpcs.2022.110958
https://doi.org/10.1016/j.jpcs.2022.110958
Autor:
Francisco de Aquino Bezerra, Gabriella de Castro Lima, Ana Caroline Lustosa de Melo Carvalho, Kimberly Benedetti Vega, Maria Conceição Ferreira Oliveira, Telma Leda Gomes de Lemos, Jose Cleiton Sousa dos Santos, Luciana Rocha Barros Gonçalves, Nathalia Saraiva Rios, Roberto Fernandez-Lafuente, Francesco Molinari, Geancarlo Zanatta, Marcos Carlos de Mattos
Publikováno v:
Molecular Catalysis. 529:112540
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6582efc39e3e648dfb2e128631d4a651
https://doi.org/10.1016/j.mcat.2022.112540
https://doi.org/10.1016/j.mcat.2022.112540
Autor:
Maurício Menegatti Rigo, Dinler A. Antunes, Lydia E. Kavraki, Sarah Hall-Swan, Didier Devaurs, Geancarlo Zanatta
Publikováno v:
bioRxiv
Computers in Biology and Medicine
Computers in Biology and Medicine
An unprecedented research effort has been undertaken in response to the ongoing COVID-19 pandemic. This has included the determination of hundreds of crystallographic structures of SARS-CoV-2 proteins, and numerous virtual screening projects searchin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf7b6e065df1131e64e2c385cc9722e
https://europepmc.org/articles/PMC7836118/
https://europepmc.org/articles/PMC7836118/
Autor:
Francisca Fernanda Nunes Azevedo, Francisca Joseli Freitas de Sousa, Francisco Lucas Santos de Oliveira, Jaqueline Vieira Carletti, Geancarlo Zanatta
The PI3K/Akt/mTOR signaling pathway plays a pivotal role in cellular metabolism, growth and survival. PI3Kα hyperactivation impairs downstream signaling, including mTOR regulation, and are linked to poor prognosis and refractory cancer treatment. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9485fb7cad5a3bf2ec3727f769059015