Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Gea, Cereghetti"'
A structural rationale for reversible vs irreversible amyloid fibril formation from a single protein
Autor:
Lukas Frey, Jiangtao Zhou, Gea Cereghetti, Marco E. Weber, David Rhyner, Aditya Pokharna, Luca Wenchel, Harindranath Kadavath, Yiping Cao, Beat H. Meier, Matthias Peter, Jason Greenwald, Roland Riek, Raffaele Mezzenga
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Reversible and irreversible amyloids are two diverging cases of protein (mis)folding associated with the cross-β motif in the protein folding and aggregation energy landscape. Yet, the molecular origins responsible for the formation of reve
Externí odkaz:
https://doaj.org/article/8b5b5edb4fa34aebba0ca7e2954be041
Autor:
Vera M. Kissling, Giordano Reginato, Eliana Bianco, Kristina Kasaciunaite, Janny Tilma, Gea Cereghetti, Natalie Schindler, Sung Sik Lee, Raphaël Guérois, Brian Luke, Ralf Seidel, Petr Cejka, Matthias Peter
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The Mre11-Rad50 (MR) complex has key functions in the detection, signaling and repair of DNA breaks. Here the authors use transmission electron microscopy to show MR oligomerization is governed by a small beta-sheet protruding from the head domain of
Externí odkaz:
https://doaj.org/article/3b0bb9efd9d04d24afb66624d538d569
Autor:
Gregor Holzner, Bogdan Mateescu, Daniel van Leeuwen, Gea Cereghetti, Reinhard Dechant, Stavros Stavrakis, Andrew deMello
Publikováno v:
Cell Reports, Vol 34, Iss 10, Pp 108824- (2021)
Summary: We present a sheathless, microfluidic imaging flow cytometer that incorporates stroboscopic illumination for blur-free fluorescence detection at ultra-high analytical throughput. The imaging platform is capable of multiparametric fluorescenc
Externí odkaz:
https://doaj.org/article/e1f55139f4cf4c199259ba92dc777b78
Autor:
Alejandro Diaz-Barreiro, Gea Cereghetti, Jenna Tonacini, Dominique Talabot-Ayer, Sylvie Kieffer-Jaquinod, Arnaud Huard, Christopher Swale, Yohann Couté, Matthias Peter, Antonio Francés-Monerris, Gaby Palmer
Cytokines of the interleukin (IL)-1 family are widely expressed in epithelial surfaces, including the epidermis, where they play a key role in the maintenance of barrier integrity and host defense. A recent report associated the IL-1 family member IL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0aebf8d06c21d71f86527c50ff0e922
https://doi.org/10.1101/2023.03.26.534252
https://doi.org/10.1101/2023.03.26.534252
Autor:
Gea Cereghetti, Vera Maria Kissling, Lisa Maria Koch, Alexandra Arm, Pavel Afanasyev, Miriam Linsenmeier, Cédric Eichmann, Jiangtao Zhou, Yiping Cao, Dorota Maria Pfizenmaier, Sonja Kroschwald, Thomas Wiegand, Riccardo Cadalbert, Daniel Böhringer, Raffaele Mezzenga, Paolo Arosio, Roland Riek, Matthias Peter
Amyloids were long viewed as irreversible, pathological aggregates, often associated with neurodegenerative diseases1. However, recent insights challenge this view, providing evidence that reversible amyloids can form upon stress conditions and fulfi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ada7aa283cdd046e01c8b7d7cd7249a
https://doi.org/10.1101/2022.03.21.484600
https://doi.org/10.1101/2022.03.21.484600
Autor:
Giordano Reginato, Sung Sik Lee, Janny Tilma, Vera M. Kissling, Petr Cejka, Ralf Seidel, Gea Cereghetti, Raphael Guerois, Eliana Bianco, Kristina Kasaciunaite, Matthias Peter
The conserved Mre11-Rad50 (MR) complex is crucial for the detection, signaling, end tethering and processing of DNA double-strand breaks (DSBs). While it was known for decades that MR foci formation at DSBs accompanies repair, the underlying molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::985d2c97de693e99e52d5b7e070088a4
https://doi.org/10.21203/rs.3.rs-811984/v1
https://doi.org/10.21203/rs.3.rs-811984/v1
Autor:
Vera M, Kissling, Giordano, Reginato, Eliana, Bianco, Kristina, Kasaciunaite, Janny, Tilma, Gea, Cereghetti, Natalie, Schindler, Sung Sik, Lee, Raphaël, Guérois, Brian, Luke, Ralf, Seidel, Petr, Cejka, Matthias, Peter
Publikováno v:
Nature communications. 13(1)
The conserved Mre11-Rad50 complex is crucial for the detection, signaling, end tethering and processing of DNA double-strand breaks. While it is known that Mre11-Rad50 foci formation at DNA lesions accompanies repair, the underlying molecular assembl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e056f71291856309b047f3159c4d59d
https://pubmed.ncbi.nlm.nih.gov/35501303
https://pubmed.ncbi.nlm.nih.gov/35501303
Autor:
D. Allan Drummond, Caroline Wilson-Zbinden, Matthias Peter, Haneul Yoo, Vera M. Kissling, Maren Diether, Alexandra Arm, Gea Cereghetti, Paola Picotti, Shady Saad, Ilaria Piazza, Reinhard Dechant, Uwe Sauer
Publikováno v:
Nature Cell Biology
Cells respond to stress by blocking translation, rewiring metabolism and forming transient messenger ribonucleoprotein assemblies called stress granules (SGs). After stress release, re-establishing homeostasis and disassembling SGs requires ATP-consu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8cd840477204bdde473244aa192f118
https://pubmed.ncbi.nlm.nih.gov/34702981
https://pubmed.ncbi.nlm.nih.gov/34702981
Autor:
Gea Cereghetti, Daniel van Leeuwen, Andrew J. deMello, Bogdan Mateescu, Stavros Stavrakis, Reinhard Dechant, Gregor Holzner
Publikováno v:
Cell Reports, Vol 34, Iss 10, Pp 108824-(2021)
Cell Reports, 34 (10)
Cell Reports, 34 (10)
We present a sheathless, microfluidic imaging flow cytometer that incorporates stroboscopic illumination for blur-free fluorescence detection at ultra-high analytical throughput. The imaging platform is capable of multiparametric fluorescence quantif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990f84c253ce9d4bf71faf5743f68e97
http://www.sciencedirect.com/science/article/pii/S2211124721001388
http://www.sciencedirect.com/science/article/pii/S2211124721001388
Autor:
Stavros Stavrakis, Reinhard Dechant, Daniel van Leeuwen, Gea Cereghetti, Andrew J. deMello, Bogdan Mateescu, Gregor Holzner
Publikováno v:
SSRN Electronic Journal.
We present a sheathless, microfluidic imaging flow cytometer that incorporates stroboscopic illumination for blur-free fluorescence detection at ultra-high analytical throughput. The imaging platform is capable of multi-parametric fluorescence quanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c7e2bbbecdd4ca3358f76d99a3caeb7
https://doi.org/10.2139/ssrn.3697329
https://doi.org/10.2139/ssrn.3697329