Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Ge-Min, Fang"'
Publikováno v:
Organic Letters. 25:3435-3439
Autor:
Yan-Ni Zhang, Yuwei Zhang, Shan Su, Han-Ying Zhu, Wei Xu, Lu Wang, Meng Wu, Kai Chen, Fei-Qiang Yu, Tong-Kuai Xi, Qin Zhou, You-Hua Xie, Ximing Qin, Honghua Ge, Lu Lu, Jie Qing, Ge-Min Fang
Publikováno v:
Chemical Communications. 58:1804-1807
We present the finding of a dimeric ACE2 peptide mimetic designed through side chain cross-linking and covalent dimerization. It has a binding affinity of 16 nM for the SARS-CoV-2 spike RBD, and effectively inhibits the SARS-CoV-2 pseudovirus in Huh7
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2530
Native chemical ligation is a widely used technique for peptide fragment condensation in aqueous solutions, which has broken through the length limitation of traditional solid-phase peptide synthesis. It can achieve high-efficient chemical synthesis
Publikováno v:
Methods in Molecular Biology ISBN: 9781071624883
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68a05bb7bd0fc786bc05fa2b90bbb9bf
https://doi.org/10.1007/978-1-0716-2489-0_2
https://doi.org/10.1007/978-1-0716-2489-0_2
Publikováno v:
Chinese Chemical Letters. 31:693-696
The deletion of the C-terminal arginine of the anaphylatoxin protein C5a reduces it receptor binding affinity. Understanding how C-terminal arginine affects the structure and bioactivity of C5a is important for the development of C5a C-terminal mimic
Autor:
Lilin Hou, Jiacheng Jiang, Chuankun Jiang, Xiangming Meng, Ge-Min Fang, Longchun Li, Yu Haizhu
Publikováno v:
Chinese Chemical Letters. 31:447-450
A novel donor-acceptor (D-A) type of two-photon (TP) fluorescent probe, i.e. Lyso-OSC, based on the lysosome-targeting morpholine group was developed. The polarity sensing coumarin group was functionalized as the acceptor and the 1-vinyl-4-methoxyben
Autor:
Donald Bierer, Jing Shi, Jingnan Chen, Changlin Tian, Shuaishuai Sun, Pan Shi, Lei Liu, Ge-Min Fang, Junyou Chen, Ji-Bin Cui, Yi-Ming Li, Fangming Wu, Rui Zhao
Publikováno v:
Chemical Science
Disulfide bridges contribute to the definition and rigidity of polypeptides, but they are inherently unstable in reducing environments and in the presence of isomerases and nucleophiles. Strategies to address these deficiencies, ideally without signi
Autor:
Kai Chen, Yang Tang, Meng Wu, Xiao-Cui Wan, Yan-Ni Zhang, Xiao-Xu Chen, Fei-Qiang Yu, Zhi-Hui Cui, Jin-Ming Ma, Zhaocai Zhou, Ge-Min Fang
Publikováno v:
Organic letters. 24(1)
We report a new pattern of a bicyclic helical peptide constructed through head-to-tail cross-linking. The described bicyclic helical peptide has a head-to-tail cross-linking arm and a C-terminal
Publikováno v:
Organic letters. 23(20)
Facile head-to-side chain cross-linking strategies are developed to generate helix-constrained peptides. In our strategies, a covalent cross-linker is incorporated at N, i+7 or N, i+1 positions to lock the peptide into a helical conformation. The des
Publikováno v:
Journal of peptide science : an official publication of the European Peptide SocietyREFERENCES. 28(2)
Long-chain scorpion toxin AaH-II isolated from Androctonus australis Hector can selectively inhibit mammalian voltage-gated sodium ion channel Nav 1.7 responsible for pain sensation. Efficient chemical synthesis of AaH-II and its derivatives is benef