Plakoglobin regulates adipocyte differentiation independently of the Wnt/β-catenin signalling pathway

Autor: F Abou Azar, Y Mugabo, S Yuen, S Allali, S Del Veliz, G Lavoie, PP Roux, GE Lim

The scaffold protein 14-3-3ζ is an established regulator of adipogenesis and postnatal adiposity. We and others have demonstrated that the 14-3-3ζ interactome to be diverse and dynamic, and it can be examined to identify novel regulators of physiol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fcbabb83d4378aaffb777ea03d153432
https://doi.org/10.1101/2022.02.03.478896

TMEM39A and TMEM131 facilitate bulk transport of ECM proteins through large COPII vesicle formation.

Autor: Sung JY; Cancer Metastasis Branch, Research Institute, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do, 10408, Republic of Korea., Lim GE; Cancer Metastasis Branch, Research Institute, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do, 10408, Republic of Korea., Goo J; Cancer Metastasis Branch, Research Institute, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do, 10408, Republic of Korea., Jung KJ; Experimental Clinical Research Center, Biomedical Research Institute, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, 13620, Republic of Korea., Chung JM; Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon, Kangwon-do, 24341, Republic of Korea., Jung HS; Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon, Kangwon-do, 24341, Republic of Korea., Kim YN; Cancer Metastasis Branch, Research Institute, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do, 10408, Republic of Korea. Electronic address: ynk@ncc.re.kr., Shim J; Cancer Metastasis Branch, Research Institute, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do, 10408, Republic of Korea. Electronic address: jaegal@ncc.re.kr.

Publikováno v: Journal of genetics and genomics = Yi chuan xue bao [J Genet Genomics] 2024 Nov 07. Date of Electronic Publication: 2024 Nov 07.

Plakoglobin regulates adipocyte differentiation independently of the Wnt/β-catenin signaling pathway.

Autor: Abou Azar F; Department of Medicine, Université de Montréal, Montréal, QC, Canada; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Mugabo Y; Department of Medicine, Université de Montréal, Montréal, QC, Canada; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Yuen S; Department of Medicine, Université de Montréal, Montréal, QC, Canada; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Del Veliz S; Department of Medicine, Université de Montréal, Montréal, QC, Canada; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Paré F; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Rial SA; Department of Medicine, Université de Montréal, Montréal, QC, Canada; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Lavoie G; Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, Québec, Canada; Department of Pathology and Cell Biology, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada., Roux PP; Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, Québec, Canada; Department of Pathology and Cell Biology, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada., Lim GE; Department of Medicine, Université de Montréal, Montréal, QC, Canada; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada. Electronic address: gareth.lim@umontreal.ca.

Publikováno v: Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2024 Apr; Vol. 1871 (4), pp. 119690. Date of Electronic Publication: 2024 Feb 15.

A high-throughput screening approach to discover potential colorectal cancer chemotherapeutics: Repurposing drugs to disrupt 14-3-3 protein-BAD interactions.

Autor: He S; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Silva LD; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Rutter GA; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.; Department of Diabetes, Endocrinology and Medicine, Faculty of Medicine, Imperial College, London, UK.; LKC School of Medicine, Nanyang Technological College, Singapore, Republic of Singapore., Lim GE; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 15. Date of Electronic Publication: 2023 Dec 15.

Identification of biomarkers for glycaemic deterioration in type 2 diabetes.

Autor: Slieker RC; Department of Epidemiology and Data Science, Amsterdam Public Health Institute, Amsterdam Cardiovascular Sciences, Amsterdam UMC, location VUMC, Amsterdam, the Netherlands.; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands., Donnelly LA; Population Health & Genomics, School of Medicine, University of Dundee, Dundee, UK., Akalestou E; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Lopez-Noriega L; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Melhem R; CHUM Research Centre and University of Montreal, Montreal, QC, Canada., Güneş A; IRCM and University of Montreal, Montreal, QC, Canada., Abou Azar F; CHUM Research Centre and University of Montreal, Montreal, QC, Canada., Efanov A; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, US., Georgiadou E; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Muniangi-Muhitu H; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Sheikh M; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Giordano GN; Department of Clinical Sciences, Lund University, Malmö, Sweden., Åkerlund M; Department of Clinical Sciences, Lund University, Malmö, Sweden., Ahlqvist E; Department of Clinical Sciences, Lund University, Malmö, Sweden., Ali A; Steno Diabetes Center Copenhagen, Gentofte, Denmark., Banasik K; Novo Nordisk Foundation Center for Protein Research, Copenhagen, Denmark., Brunak S; Novo Nordisk Foundation Center for Protein Research, Copenhagen, Denmark., Barovic M; Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus and Medical Faculty, Dresden, Germany., Bouland GA; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands., Burdet F; Vital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland., Canouil M; INSERM U1283, CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille University Hospital, Lille, F-59000, France., Dragan I; Vital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland., Elders PJM; Department of General Practice and Elderly Care Medicine, Amsterdam Public Health Research Institute, Amsterdam UMC-location VUmc, Amsterdam, the Netherlands., Fernandez C; Department of Clinical Sciences, Lund University, Malmö, Sweden., Festa A; Eli Lilly Regional Operations GmbH, Vienna, Austria.; 1st Medical Department, LK Stockerau, Niederösterreich, Austria., Fitipaldi H; Department of Clinical Sciences, Lund University, Malmö, Sweden., Froguel P; INSERM U1283, CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille University Hospital, Lille, F-59000, France.; Division of Systems Biology, Department of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK., Gudmundsdottir V; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Icelandic Heart Association, Kopavogur, Iceland., Gudnason V; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Icelandic Heart Association, Kopavogur, Iceland., Gerl MJ; Lipotype GmbH, Dresden, Germany., van der Heijden AA; Department of General Practice and Elderly Care Medicine, Amsterdam Public Health Research Institute, Amsterdam UMC-location VUmc, Amsterdam, the Netherlands., Jennings LL; Novartis Institutes for Biomedical Research, Cambridge, MA, 02139, USA., Hansen MK; Cardiovascular and Metabolic Disease Research, Janssen Research & Development, Spring House, PA, USA., Kim M; Steno Diabetes Center Copenhagen, Gentofte, Denmark.; Institute of Pharmaceutical Science, Faculty of Life Sciences and Medicines, King's College London, London, UK., Leclerc I; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; CHUM Research Centre and University of Montreal, Montreal, QC, Canada., Klose C; Lipotype GmbH, Dresden, Germany., Kuznetsov D; Vital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland., Mansour Aly D; Department of Clinical Sciences, Lund University, Malmö, Sweden., Mehl F; Vital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland., Marek D; Vital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland., Melander O; Department of Clinical Sciences, Lund University, Malmö, Sweden., Niknejad A; Vital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland., Ottosson F; Department of Clinical Sciences, Lund University, Malmö, Sweden.; Section for Clinical Mass Spectrometry, Danish Center for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark., Pavo I; Eli Lilly Regional Operations GmbH, Vienna, Austria., Duffin K; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, US., Syed SK; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, US., Shaw JL; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, US., Cabrera O; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, US., Pullen TJ; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Diabetes, Guy's Campus King's College London, London, UK., Simons K; Lipotype GmbH, Dresden, Germany., Solimena M; Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus and Medical Faculty, Dresden, Germany.; Molecular Diabetology, University Hospital and Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany., Suvitaival T; Steno Diabetes Center Copenhagen, Gentofte, Denmark., Wretlind A; Steno Diabetes Center Copenhagen, Gentofte, Denmark., Rossing P; Steno Diabetes Center Copenhagen, Gentofte, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Lyssenko V; Department of Clinical Science, Center for Diabetes Research, University of Bergen, Bergen, Norway.; Genomics, Diabetes and Endocrinology Unit, Department of Clinical Sciences Malmö, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden., Legido Quigley C; Steno Diabetes Center Copenhagen, Gentofte, Denmark.; Institute of Pharmaceutical Science, Faculty of Life Sciences and Medicines, King's College London, London, UK., Groop L; Department of Clinical Sciences, Lund University, Malmö, Sweden.; Finnish Institute of Molecular Medicine, Helsinki University, Helsinki, Finland., Thorens B; Center for Integrative Genomics, University of Lausanne, CH-1015, Lausanne, Switzerland., Franks PW; Department of Clinical Sciences, Lund University, Malmö, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA., Lim GE; CHUM Research Centre and University of Montreal, Montreal, QC, Canada., Estall J; IRCM and University of Montreal, Montreal, QC, Canada., Ibberson M; Vital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland., Beulens JWJ; Department of Epidemiology and Data Science, Amsterdam Public Health Institute, Amsterdam Cardiovascular Sciences, Amsterdam UMC, location VUMC, Amsterdam, the Netherlands.; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands., 't Hart LM; Department of Epidemiology and Data Science, Amsterdam Public Health Institute, Amsterdam Cardiovascular Sciences, Amsterdam UMC, location VUMC, Amsterdam, the Netherlands. lmthart@lumc.nl.; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands. lmthart@lumc.nl.; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands. lmthart@lumc.nl., Pearson ER; Population Health & Genomics, School of Medicine, University of Dundee, Dundee, UK. E.Z.Pearson@dundee.ac.uk., Rutter GA; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. g.rutter@imperial.ac.uk.; CHUM Research Centre and University of Montreal, Montreal, QC, Canada. g.rutter@imperial.ac.uk.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. g.rutter@imperial.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2023 May 03; Vol. 14 (1), pp. 2533. Date of Electronic Publication: 2023 May 03.