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Neurokinin-1 receptor is an effective target for treating leukemia by inducing oxidative stress through mitochondrial calcium overload

Autor: Qi Chen, Xi Wang, Liangjue Liu, Caiyun Fu, Feiyan Huang, Zhou Hanwei, Ge Chentao, Hongzhang Wu, Jian Kang, Yue Shi, Yanfang Sun, Hemiao Huang, Yihai Cao, Tianxin Yang, Teng-Fei Zhang, Richard B. Pearson

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance Despite tremendous efforts in developing effective therapeutics for treating acute myeloid leukemia (AML), this hematological disease remains an incurable malignancy. Here, we show surprising findings that neurokinin-1 receptor (NK-1R) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f7616d4c3ec02ccf9e33a7bd24b03c
https://pubmed.ncbi.nlm.nih.gov/31488714

Neurokinin-2 receptor antagonist SR48968 induced necroptosis of myeloid leukemia cells by calcium overload-driven reactive oxygen species accumulation.

Autor: Yan Z; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, China., Hong X; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, China., Lin Q; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, China., Wang L; College of Life Sciences, China Jiliang University, Hangzhou, Zhejiang 310018, China., Shao G; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, China., Ge C; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, China., Xia R; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, China., Fu C; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, China.

Publikováno v: Genes & diseases [Genes Dis] 2023 Sep 20; Vol. 11 (5), pp. 101098. Date of Electronic Publication: 2023 Sep 20 (Print Publication: 2024).